Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893887682> ?p ?o ?g. }
- W2893887682 endingPage "721" @default.
- W2893887682 startingPage "699" @default.
- W2893887682 abstract "Hydroxyapatite (HA) possesses similar mineral components to bone and possesses good physicochemical properties. Even though pure HA scaffold is brittle, it is insufficient in promoting vascularization and osteoinductivity. This study was conducted to assess whether lithium (Li) incorporated into HA could improve the scaffolds' inherent shortcomings. In the experiments, Li-hydroxyapatite scaffolds' mechanical strength, biocompatibility, and biodegradability were researched primarily. In vivo studies, the Li hydroxyapatite scaffolds were implanted into an animal model to repair the bone defects. Meanwhile, we also evaluated the expression of angiogenic and osteogenic factors. For comparison, autologous bone, hydroxyapatite, and blank control groups were designed. According to the results, Li incorporated with hydroxyapatite did not significantly change the scaffold's degradation velocity, but it obtained higher compress mechanical strength. After Li was doped, bone regeneration was further enhanced but the angiogenic effect was not improved significantly. The in vivo study, Li-HA scaffolds improved new bone formation with GSK-3훽 decreased and 훽-catenin increased. In conclusion, doped Li into hydroxyapatite was an alternative strategy for improving hydroxyapatite's mechanical property and promoting the osteogenesis potential. This method is highly recommended for clinical application based on this study alone." @default.
- W2893887682 created "2018-10-05" @default.
- W2893887682 creator A5008358099 @default.
- W2893887682 creator A5068377170 @default.
- W2893887682 creator A5081393364 @default.
- W2893887682 creator A5081853924 @default.
- W2893887682 date "2018-11-14" @default.
- W2893887682 modified "2023-10-05" @default.
- W2893887682 title "In vivo evaluation of porous lithium-doped hydroxyapatite scaffolds for the treatment of bone defect" @default.
- W2893887682 cites W1897492636 @default.
- W2893887682 cites W1970893419 @default.
- W2893887682 cites W1982175365 @default.
- W2893887682 cites W1986285196 @default.
- W2893887682 cites W1986556340 @default.
- W2893887682 cites W1995358650 @default.
- W2893887682 cites W1996765709 @default.
- W2893887682 cites W2000292756 @default.
- W2893887682 cites W2001380203 @default.
- W2893887682 cites W2008274313 @default.
- W2893887682 cites W2010221831 @default.
- W2893887682 cites W2014637539 @default.
- W2893887682 cites W2020066600 @default.
- W2893887682 cites W2020179999 @default.
- W2893887682 cites W2029282014 @default.
- W2893887682 cites W2031815923 @default.
- W2893887682 cites W2034887444 @default.
- W2893887682 cites W2035919665 @default.
- W2893887682 cites W2041571480 @default.
- W2893887682 cites W2043303130 @default.
- W2893887682 cites W2047886959 @default.
- W2893887682 cites W2049855831 @default.
- W2893887682 cites W2053395922 @default.
- W2893887682 cites W2065453838 @default.
- W2893887682 cites W2067595293 @default.
- W2893887682 cites W2078965438 @default.
- W2893887682 cites W2079526454 @default.
- W2893887682 cites W2080934801 @default.
- W2893887682 cites W2091312818 @default.
- W2893887682 cites W2093836732 @default.
- W2893887682 cites W2105054202 @default.
- W2893887682 cites W2107988120 @default.
- W2893887682 cites W2117284590 @default.
- W2893887682 cites W2132131875 @default.
- W2893887682 cites W2135457199 @default.
- W2893887682 cites W2141601710 @default.
- W2893887682 cites W2163341100 @default.
- W2893887682 cites W2166477100 @default.
- W2893887682 cites W2185873440 @default.
- W2893887682 cites W2312673008 @default.
- W2893887682 cites W2326108366 @default.
- W2893887682 cites W2340864431 @default.
- W2893887682 cites W2341755468 @default.
- W2893887682 cites W2405421240 @default.
- W2893887682 cites W2507573772 @default.
- W2893887682 cites W2563602166 @default.
- W2893887682 cites W2570590878 @default.
- W2893887682 cites W2573571974 @default.
- W2893887682 cites W2583396949 @default.
- W2893887682 cites W2597557839 @default.
- W2893887682 cites W2626362463 @default.
- W2893887682 cites W2750238272 @default.
- W2893887682 cites W2752609731 @default.
- W2893887682 cites W2784087245 @default.
- W2893887682 cites W2792346369 @default.
- W2893887682 doi "https://doi.org/10.3233/bme-181018" @default.
- W2893887682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30282329" @default.
- W2893887682 hasPublicationYear "2018" @default.
- W2893887682 type Work @default.
- W2893887682 sameAs 2893887682 @default.
- W2893887682 citedByCount "14" @default.
- W2893887682 countsByYear W28938876822018 @default.
- W2893887682 countsByYear W28938876822019 @default.
- W2893887682 countsByYear W28938876822021 @default.
- W2893887682 countsByYear W28938876822022 @default.
- W2893887682 crossrefType "journal-article" @default.
- W2893887682 hasAuthorship W2893887682A5008358099 @default.
- W2893887682 hasAuthorship W2893887682A5068377170 @default.
- W2893887682 hasAuthorship W2893887682A5081393364 @default.
- W2893887682 hasAuthorship W2893887682A5081853924 @default.
- W2893887682 hasConcept C134018914 @default.
- W2893887682 hasConcept C136229726 @default.
- W2893887682 hasConcept C141071460 @default.
- W2893887682 hasConcept C150903083 @default.
- W2893887682 hasConcept C185592680 @default.
- W2893887682 hasConcept C191897082 @default.
- W2893887682 hasConcept C192562407 @default.
- W2893887682 hasConcept C207001950 @default.
- W2893887682 hasConcept C2776541429 @default.
- W2893887682 hasConcept C2776886416 @default.
- W2893887682 hasConcept C2777230088 @default.
- W2893887682 hasConcept C2778541603 @default.
- W2893887682 hasConcept C71924100 @default.
- W2893887682 hasConcept C8337478 @default.
- W2893887682 hasConcept C86803240 @default.
- W2893887682 hasConcept C89429830 @default.
- W2893887682 hasConceptScore W2893887682C134018914 @default.
- W2893887682 hasConceptScore W2893887682C136229726 @default.
- W2893887682 hasConceptScore W2893887682C141071460 @default.