FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893889295> ?p ?o ?g. }

• W2893889295 endingPage "257" @default.
• W2893889295 startingPage "249" @default.
• W2893889295 abstract "Endoplasmic reticulum (ER) stress is a significant contributor to neurodegeneration and cognitive dysfunction. Recently, we reported that repeated exposure to the pyrethroid insecticide deltamethrin caused ER stress in the hippocampus of adult mice, which was accompanied by deficits in learning (Hossain et al., 2015). Here, we investigated regional susceptibility to ER stress and the ability of salubrinal, an inhibitor of ER stress, to reduce apoptosis following a single oral administration of deltamethrin (6 mg/kg). Deltamethrin significantly increased the ER stress marker C/EBP-homologous protein (CHOP) in the hippocampus by 148% at 24 and 48 h compared with age-matched controls. In contrast, CHOP was increased by 146% in the frontal cortex only at 48 h after deltamethrin exposure. Similarly, the level of GRP-78 was increased by 314% and 262% in the hippocampus at 24 and 48 h, whereas the same factors were increased by 178% at 24 h and 139% at 48 h in the frontal cortex. These changes were accompanied by increased levels of activated caspase-12, caspase-3, and TUNEL-positive cells in both brain regions, with the hippocampus showing a more robust response. Pre-treatment of mice with the eIf2α inhibitor salubrinal prevented deltamethrin-induced caspase-3 activation and attenuated the number of TUNEL-positive cells. These data demonstrate that the hippocampus appears to be particularly vulnerable to deltamethrin exposure in adult animals, which may contribute to observed effects of deltamethrin on cognitive function." @default.
• W2893889295 created "2018-10-05" @default.
• W2893889295 creator A5017294315 @default.
• W2893889295 creator A5021586993 @default.
• W2893889295 creator A5045586758 @default.
• W2893889295 date "2018-09-22" @default.
• W2893889295 modified "2023-10-17" @default.
• W2893889295 title "Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin" @default.
• W2893889295 cites W1604309017 @default.
• W2893889295 cites W1697178647 @default.
• W2893889295 cites W1758898161 @default.
• W2893889295 cites W1834667032 @default.
• W2893889295 cites W1839083945 @default.
• W2893889295 cites W1970222831 @default.
• W2893889295 cites W1972984384 @default.
• W2893889295 cites W1976161806 @default.
• W2893889295 cites W1978214058 @default.
• W2893889295 cites W1980401437 @default.
• W2893889295 cites W2000978940 @default.
• W2893889295 cites W2001399725 @default.
• W2893889295 cites W2006687288 @default.
• W2893889295 cites W2017320893 @default.
• W2893889295 cites W2023238890 @default.
• W2893889295 cites W2025511820 @default.
• W2893889295 cites W2038267430 @default.
• W2893889295 cites W2042141743 @default.
• W2893889295 cites W2042392978 @default.
• W2893889295 cites W2043387126 @default.
• W2893889295 cites W2050157952 @default.
• W2893889295 cites W2050490622 @default.
• W2893889295 cites W2052019374 @default.
• W2893889295 cites W2054236618 @default.
• W2893889295 cites W2056442763 @default.
• W2893889295 cites W2061567649 @default.
• W2893889295 cites W2064950130 @default.
• W2893889295 cites W2068448989 @default.
• W2893889295 cites W2079613741 @default.
• W2893889295 cites W2085933321 @default.
• W2893889295 cites W2089198803 @default.
• W2893889295 cites W2090556647 @default.
• W2893889295 cites W2094873226 @default.
• W2893889295 cites W2095428889 @default.
• W2893889295 cites W2098896781 @default.
• W2893889295 cites W2104631723 @default.
• W2893889295 cites W2109001751 @default.
• W2893889295 cites W2113254662 @default.
• W2893889295 cites W2119836843 @default.
• W2893889295 cites W2122054000 @default.
• W2893889295 cites W2130911810 @default.
• W2893889295 cites W2133644385 @default.
• W2893889295 cites W2139568257 @default.
• W2893889295 cites W2140487984 @default.
• W2893889295 cites W2146266314 @default.
• W2893889295 cites W2153078832 @default.
• W2893889295 cites W2154500525 @default.
• W2893889295 cites W2155104195 @default.
• W2893889295 cites W2165064047 @default.
• W2893889295 cites W2167500696 @default.
• W2893889295 cites W2171089964 @default.
• W2893889295 cites W2172115472 @default.
• W2893889295 cites W2311621028 @default.
• W2893889295 cites W2521392402 @default.
• W2893889295 cites W4244867058 @default.
• W2893889295 cites W1964184380 @default.
• W2893889295 doi "https://doi.org/10.1093/toxsci/kfy238" @default.
• W2893889295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6317433" @default.
• W2893889295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247739" @default.
• W2893889295 hasPublicationYear "2018" @default.
• W2893889295 type Work @default.
• W2893889295 sameAs 2893889295 @default.
• W2893889295 citedByCount "18" @default.
• W2893889295 countsByYear W28938892952019 @default.
• W2893889295 countsByYear W28938892952020 @default.
• W2893889295 countsByYear W28938892952021 @default.
• W2893889295 countsByYear W28938892952022 @default.
• W2893889295 countsByYear W28938892952023 @default.
• W2893889295 crossrefType "journal-article" @default.
• W2893889295 hasAuthorship W2893889295A5017294315 @default.
• W2893889295 hasAuthorship W2893889295A5021586993 @default.
• W2893889295 hasAuthorship W2893889295A5045586758 @default.
• W2893889295 hasBestOaLocation W28938892951 @default.
• W2893889295 hasConcept C126322002 @default.
• W2893889295 hasConcept C134018914 @default.
• W2893889295 hasConcept C139447449 @default.
• W2893889295 hasConcept C161176658 @default.
• W2893889295 hasConcept C185592680 @default.
• W2893889295 hasConcept C190283241 @default.
• W2893889295 hasConcept C2777553912 @default.
• W2893889295 hasConcept C2779338263 @default.
• W2893889295 hasConcept C2779725641 @default.
• W2893889295 hasConcept C2781161787 @default.
• W2893889295 hasConcept C55493867 @default.
• W2893889295 hasConcept C6557445 @default.
• W2893889295 hasConcept C71924100 @default.
• W2893889295 hasConcept C86803240 @default.
• W2893889295 hasConceptScore W2893889295C126322002 @default.
• W2893889295 hasConceptScore W2893889295C134018914 @default.
• W2893889295 hasConceptScore W2893889295C139447449 @default.

• next