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- W2893893071 abstract "Abstract Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell (iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the extent of preserved epigenetic and transcriptional aging signatures in directly converted induced neural stem cells (iNSCs). Employing restricted and integration-free expression of SOX2 and c-MYC, we generated a fully functional, bona fide NSC population from adult blood cells that remains highly responsive to regional patterning cues. Upon conversion, low passage iNSCs display a profound loss of age-related DNA methylation signatures, which further erode across extended passaging, thereby approximating the DNA methylation age of isogenic iPSC-derived neural precursors. This epigenetic rejuvenation is accompanied by a lack of age-associated transcriptional signatures and absence of cellular aging hallmarks. We find iNSCs to be competent for modeling pathological protein aggregation and for neurotransplantation, depicting blood-to-NSC conversion as a rapid alternative route for both disease modeling and neuroregeneration." @default.
- W2893893071 created "2018-10-05" @default.
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- W2893893071 date "2018-10-02" @default.
- W2893893071 modified "2023-10-11" @default.
- W2893893071 title "A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation" @default.
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- W2893893071 doi "https://doi.org/10.1038/s41467-018-06398-5" @default.
- W2893893071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168501" @default.
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