Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893899321> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2893899321 abstract "Introduction The benefit of aspirin in preventing preeclampsia is well established. Recent data, however, suggest variability in outcomes with its use. Two potential contributing factors are the dose and preparation of aspirin. Objective/hypothesis To determine the: pharmacokinetics of 100 mg coated (Coated100) vs 100 mg non-coated (NonCoated100) vs 150 mg non-coated (NonCoated150) aspirin. Pharmacokinetics of the above in male vs non-pregnant vs gestation-matched pregnant female subjects. Methods Three subjects from each group were given Coated100, NonCoated100 or NonCoated150 aspirin at different times. Blood samples were collected pre-ingestion, 1-h post, 2-h post, 4-h post, 6-h post, 12-h post and 24-h post-ingestion of aspirin. Samples were analysed for plasma salicylate acid (SA) utilising a validated liquid chromatography mass-spectrometry (LCMS) methodology. The differences in the area under the curves (AUC) were analysed using Kruskal-Wallis and Mann-Whitney-U (SPSS). Results The AUCs of Coated100, NonCoated100 and NonCoated150 were different across all three groups of subjects (p Discussion The pharmacokinetics of aspirin between male, non-pregnant and pregnant female differs, with lower AUCs in pregnant females. There is no difference in the dose-matched AUCs between coated and non-coated aspirin but a difference was noted in AUCs between preparation-matched 100 mg and 150 mg of Aspirin. The clinical significance of this in the high-risk pregnant women is yet to be examined, however, potentially supports the need for a higher dose of aspirin in pregnant women." @default.
- W2893899321 created "2018-10-05" @default.
- W2893899321 creator A5002654216 @default.
- W2893899321 creator A5031669925 @default.
- W2893899321 creator A5045840929 @default.
- W2893899321 creator A5068893762 @default.
- W2893899321 creator A5069953239 @default.
- W2893899321 creator A5080166188 @default.
- W2893899321 creator A5087149945 @default.
- W2893899321 creator A5065530886 @default.
- W2893899321 date "2018-10-01" @default.
- W2893899321 modified "2023-09-24" @default.
- W2893899321 title "262. A pharmacokinetic assessment of aspirin through timed analysis of plasma salicylate acid level: An analysis of difference in gender, dose and preparation of aspirin" @default.
- W2893899321 doi "https://doi.org/10.1016/j.preghy.2018.08.334" @default.
- W2893899321 hasPublicationYear "2018" @default.
- W2893899321 type Work @default.
- W2893899321 sameAs 2893899321 @default.
- W2893899321 citedByCount "0" @default.
- W2893899321 crossrefType "journal-article" @default.
- W2893899321 hasAuthorship W2893899321A5002654216 @default.
- W2893899321 hasAuthorship W2893899321A5031669925 @default.
- W2893899321 hasAuthorship W2893899321A5045840929 @default.
- W2893899321 hasAuthorship W2893899321A5065530886 @default.
- W2893899321 hasAuthorship W2893899321A5068893762 @default.
- W2893899321 hasAuthorship W2893899321A5069953239 @default.
- W2893899321 hasAuthorship W2893899321A5080166188 @default.
- W2893899321 hasAuthorship W2893899321A5087149945 @default.
- W2893899321 hasConcept C112705442 @default.
- W2893899321 hasConcept C126322002 @default.
- W2893899321 hasConcept C12868164 @default.
- W2893899321 hasConcept C193230392 @default.
- W2893899321 hasConcept C2777628954 @default.
- W2893899321 hasConcept C71924100 @default.
- W2893899321 hasConcept C98274493 @default.
- W2893899321 hasConceptScore W2893899321C112705442 @default.
- W2893899321 hasConceptScore W2893899321C126322002 @default.
- W2893899321 hasConceptScore W2893899321C12868164 @default.
- W2893899321 hasConceptScore W2893899321C193230392 @default.
- W2893899321 hasConceptScore W2893899321C2777628954 @default.
- W2893899321 hasConceptScore W2893899321C71924100 @default.
- W2893899321 hasConceptScore W2893899321C98274493 @default.
- W2893899321 hasLocation W28938993211 @default.
- W2893899321 hasOpenAccess W2893899321 @default.
- W2893899321 hasPrimaryLocation W28938993211 @default.
- W2893899321 hasRelatedWork W2135900226 @default.
- W2893899321 hasRelatedWork W2137532808 @default.
- W2893899321 hasRelatedWork W2283005868 @default.
- W2893899321 hasRelatedWork W2328940178 @default.
- W2893899321 hasRelatedWork W2526630190 @default.
- W2893899321 hasRelatedWork W2737554635 @default.
- W2893899321 hasRelatedWork W2893899321 @default.
- W2893899321 hasRelatedWork W4248522985 @default.
- W2893899321 hasRelatedWork W4255203891 @default.
- W2893899321 hasRelatedWork W6516669 @default.
- W2893899321 isParatext "false" @default.
- W2893899321 isRetracted "false" @default.
- W2893899321 magId "2893899321" @default.
- W2893899321 workType "article" @default.