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- W2893903899 abstract "Neurodegenerative disorders have a complex pathology and are characterized by a progressive loss of neuronal architecture in the brain or spinal cord. Neuroprotective agents have demonstrated promising results at the preclinical stage, but this has not been confirmed at the clinical stage. Thus far, no neuroprotective drug that can prevent neuronal degeneration in patients with neurodegenerative disorders is available. Recent studies have focused on neurorestorative measures, such as cell-based therapy, rather than neuroprotective treatment. The utility of cell-based approaches for the treatment of neurodegenerative disorders has been explored extensively, and the results have been somewhat promising with regard to reversing the outcome. Because of their neural crest origin, ease of harvest, accessibility, ethical suitability, and potential to differentiate into the neurogenic lineage, dental-derived stem cells (DSCs) have become an attractive source for cell-based neurorestoration therapies. In the present review, we summarize the possible use of DSC-based neurorestoration therapy as an alternative treatment for neurodegenerative disorders, with a particular emphasis on the mechanism underlying recovery in neurodegenerative disorders. Transplantation research in neurodegenerative diseases should aim to understand the mechanism providing benefits both at the molecular and functional level. Due to their ease of accessibility, plasticity, and ethical suitability, DSCs hold promise to overcome the existing challenges in the field of neurodegeneration through multiple mechanisms, such as cell replacement, bystander effect, vasculogenesis, synaptogenesis, immunomodulation, and by inhibiting apoptosis." @default.
- W2893903899 created "2018-10-05" @default.
- W2893903899 creator A5011850640 @default.
- W2893903899 creator A5033410228 @default.
- W2893903899 creator A5036589842 @default.
- W2893903899 creator A5045404133 @default.
- W2893903899 date "2018-09-26" @default.
- W2893903899 modified "2023-10-15" @default.
- W2893903899 title "Mechanisms underlying dental-derived stem cell-mediated neurorestoration in neurodegenerative disorders" @default.
- W2893903899 cites W1085537402 @default.
- W2893903899 cites W1110918352 @default.
- W2893903899 cites W1483365010 @default.
- W2893903899 cites W1485794983 @default.
- W2893903899 cites W1505870579 @default.
- W2893903899 cites W1509471188 @default.
- W2893903899 cites W1509474425 @default.
- W2893903899 cites W1585630836 @default.
- W2893903899 cites W1603472581 @default.
- W2893903899 cites W1735480321 @default.
- W2893903899 cites W1765146139 @default.
- W2893903899 cites W1837964383 @default.
- W2893903899 cites W1871697889 @default.
- W2893903899 cites W1956428707 @default.
- W2893903899 cites W1964237953 @default.
- W2893903899 cites W1965727192 @default.
- W2893903899 cites W1966443300 @default.
- W2893903899 cites W1974521830 @default.
- W2893903899 cites W1977213877 @default.
- W2893903899 cites W1977845985 @default.
- W2893903899 cites W1985018811 @default.
- W2893903899 cites W1989696297 @default.
- W2893903899 cites W1990442755 @default.
- W2893903899 cites W1992218960 @default.
- W2893903899 cites W1994056403 @default.
- W2893903899 cites W1995673576 @default.
- W2893903899 cites W1996273748 @default.
- W2893903899 cites W2001091320 @default.
- W2893903899 cites W2003848471 @default.
- W2893903899 cites W2003982930 @default.
- W2893903899 cites W2011337600 @default.
- W2893903899 cites W2011403734 @default.
- W2893903899 cites W2015262351 @default.
- W2893903899 cites W2017546292 @default.
- W2893903899 cites W2019635786 @default.
- W2893903899 cites W2021268653 @default.
- W2893903899 cites W2021428981 @default.
- W2893903899 cites W2024573693 @default.
- W2893903899 cites W2024579131 @default.
- W2893903899 cites W2025133939 @default.
- W2893903899 cites W2027654288 @default.
- W2893903899 cites W2030416589 @default.
- W2893903899 cites W2030491608 @default.
- W2893903899 cites W2033690040 @default.
- W2893903899 cites W2035613497 @default.
- W2893903899 cites W2044810442 @default.
- W2893903899 cites W2045183077 @default.
- W2893903899 cites W2046328854 @default.
- W2893903899 cites W2049502800 @default.
- W2893903899 cites W2054991182 @default.
- W2893903899 cites W2056274924 @default.
- W2893903899 cites W2059017998 @default.
- W2893903899 cites W2061739297 @default.
- W2893903899 cites W2061954426 @default.
- W2893903899 cites W2062185836 @default.
- W2893903899 cites W2067856703 @default.
- W2893903899 cites W2069269303 @default.
- W2893903899 cites W2070240681 @default.
- W2893903899 cites W2074919825 @default.
- W2893903899 cites W2076002566 @default.
- W2893903899 cites W2076892347 @default.
- W2893903899 cites W2079376639 @default.
- W2893903899 cites W2079727280 @default.
- W2893903899 cites W2085424855 @default.
- W2893903899 cites W2094689616 @default.
- W2893903899 cites W2097556137 @default.
- W2893903899 cites W2099805671 @default.
- W2893903899 cites W2102462389 @default.
- W2893903899 cites W2102726602 @default.
- W2893903899 cites W2106413293 @default.
- W2893903899 cites W2110804473 @default.
- W2893903899 cites W2113999599 @default.
- W2893903899 cites W2115437022 @default.
- W2893903899 cites W2116864112 @default.
- W2893903899 cites W2119610794 @default.
- W2893903899 cites W2121081109 @default.
- W2893903899 cites W2121998108 @default.
- W2893903899 cites W2123165278 @default.
- W2893903899 cites W2132691049 @default.
- W2893903899 cites W2134979684 @default.
- W2893903899 cites W2136767600 @default.
- W2893903899 cites W2138475604 @default.
- W2893903899 cites W2142072238 @default.
- W2893903899 cites W2142594288 @default.
- W2893903899 cites W2144224215 @default.
- W2893903899 cites W2145040826 @default.
- W2893903899 cites W2148562877 @default.
- W2893903899 cites W2148905734 @default.
- W2893903899 cites W2153413302 @default.
- W2893903899 cites W2155678564 @default.
- W2893903899 cites W2156895150 @default.