FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893905632> ?p ?o ?g. }

• W2893905632 endingPage "5907" @default.
• W2893905632 startingPage "5887" @default.
• W2893905632 abstract "Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis Yao-Xing Dou,1,2,* Jiang-Tao Zhou,3,4,* Tong-Tong Wang,2 Yan-Feng Huang,1 Vicky Ping Chen,5 You-Liang Xie,1 Zhi-Xiu Lin,6 Jian-Sheng Gao,7 Zi-Ren Su,1 Hui-Fang Zeng2 1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, People’s Republic of China; 5Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China; 7Guangzhou Baiyunshan Mingxing Pharmaceutical Co. Ltd., Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Results: The prepared nanoemulsion has multiple beneficial aspects including small mean droplet size, low polydispersity index (PDI), high zeta potential (ZP) and excellent stability. Transmission electron microscopy showed that nanoemulsion droplets contained uniform shape and size of globules. Pharmacokinetic studies demonstrated that BD-SNEDDS exhibited enhanced pharmacokinetic parameters as compared with BD-suspension. Moreover, BD-SNEDDS significantly restored the colon length and body weight, reduced disease activity index (DAI) and colon pathology, decreased histological scores, diminished oxidative stress, and suppressed TLR4, MyD88, TRAF6, NF-κB p65 protein expressions in TNBS-induced UC rat model. Conclusion: These results demonstrated that BD-SNEDDS exhibited highly improved oral bioavailability and advanced anti-UC efficacy. In conclusion, our current results provided a foundation for further research of BD-SNEDDS as a potential complementary therapeutic agent for UC treatment. Keywords: bruceine D, self-nanoemulsifying drug delivery system, physicochemical properties, pharmacokinetics, anti-inflammation, anti-colitis activity" @default.
• W2893905632 created "2018-10-05" @default.
• W2893905632 creator A5004560402 @default.
• W2893905632 creator A5008712473 @default.
• W2893905632 creator A5011867289 @default.
• W2893905632 creator A5012070551 @default.
• W2893905632 creator A5012869495 @default.
• W2893905632 creator A5025107250 @default.
• W2893905632 creator A5036212714 @default.
• W2893905632 creator A5043045724 @default.
• W2893905632 creator A5065879091 @default.
• W2893905632 creator A5091572919 @default.
• W2893905632 date "2018-09-01" @default.
• W2893905632 modified "2023-10-18" @default.
• W2893905632 title "Self-nanoemulsfiying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis" @default.
• W2893905632 cites W1679579176 @default.
• W2893905632 cites W1925706468 @default.
• W2893905632 cites W1970779098 @default.
• W2893905632 cites W1972547149 @default.
• W2893905632 cites W1979363781 @default.
• W2893905632 cites W1987166489 @default.
• W2893905632 cites W1987304772 @default.
• W2893905632 cites W1989426152 @default.
• W2893905632 cites W1995563250 @default.
• W2893905632 cites W2000322677 @default.
• W2893905632 cites W2003440769 @default.
• W2893905632 cites W2004465286 @default.
• W2893905632 cites W2014688741 @default.
• W2893905632 cites W2022084212 @default.
• W2893905632 cites W2029085016 @default.
• W2893905632 cites W2036270563 @default.
• W2893905632 cites W2074282254 @default.
• W2893905632 cites W2081817465 @default.
• W2893905632 cites W2085637472 @default.
• W2893905632 cites W2086302743 @default.
• W2893905632 cites W2097997523 @default.
• W2893905632 cites W2111488320 @default.
• W2893905632 cites W2116147432 @default.
• W2893905632 cites W2141335211 @default.
• W2893905632 cites W2144417922 @default.
• W2893905632 cites W2146906769 @default.
• W2893905632 cites W2149346046 @default.
• W2893905632 cites W2157002193 @default.
• W2893905632 cites W2159713677 @default.
• W2893905632 cites W2166547808 @default.
• W2893905632 cites W2166775964 @default.
• W2893905632 cites W2171059179 @default.
• W2893905632 cites W2178566214 @default.
• W2893905632 cites W2231917894 @default.
• W2893905632 cites W2266781794 @default.
• W2893905632 cites W2309504753 @default.
• W2893905632 cites W2319796301 @default.
• W2893905632 cites W2343000836 @default.
• W2893905632 cites W2400777710 @default.
• W2893905632 cites W2462943904 @default.
• W2893905632 cites W2476625276 @default.
• W2893905632 cites W2484179329 @default.
• W2893905632 cites W2484955265 @default.
• W2893905632 cites W2497563413 @default.
• W2893905632 cites W2509319161 @default.
• W2893905632 cites W2509573709 @default.
• W2893905632 cites W2517347796 @default.
• W2893905632 cites W2524213680 @default.
• W2893905632 cites W2525934319 @default.
• W2893905632 cites W2552400040 @default.
• W2893905632 cites W2570568525 @default.
• W2893905632 cites W2582435125 @default.
• W2893905632 cites W2588748087 @default.
• W2893905632 cites W2589011850 @default.
• W2893905632 cites W2589317780 @default.
• W2893905632 cites W2591683990 @default.
• W2893905632 cites W2598560533 @default.
• W2893905632 cites W2600468570 @default.
• W2893905632 cites W2606071390 @default.
• W2893905632 cites W2606286532 @default.
• W2893905632 cites W2606570580 @default.
• W2893905632 cites W2613345879 @default.
• W2893905632 cites W2616944621 @default.
• W2893905632 cites W2618809296 @default.
• W2893905632 cites W2626223203 @default.
• W2893905632 cites W2726956030 @default.
• W2893905632 cites W2732571380 @default.
• W2893905632 cites W2740744256 @default.
• W2893905632 cites W2752465042 @default.
• W2893905632 cites W2766916205 @default.
• W2893905632 cites W2775873017 @default.
• W2893905632 cites W2793923277 @default.
• W2893905632 cites W2800718885 @default.
• W2893905632 cites W2802775129 @default.
• W2893905632 doi "https://doi.org/10.2147/ijn.s174146" @default.
• W2893905632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167998" @default.
• W2893905632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30319255" @default.
• W2893905632 hasPublicationYear "2018" @default.
• W2893905632 type Work @default.
• W2893905632 sameAs 2893905632 @default.
• W2893905632 citedByCount "40" @default.
• W2893905632 countsByYear W28939056322019 @default.
• W2893905632 countsByYear W28939056322020 @default.

• next