FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893907400> ?p ?o ?g. }

• W2893907400 endingPage "454" @default.
• W2893907400 startingPage "439" @default.
• W2893907400 abstract "Abstract Trisomy 21 or Down syndrome (DS) causes multiple adverse traits including cognitive, skeletal, craniofacial, and cardiac abnormalities. Once considered an intractable disorder, mouse models and clinical trials now pursue treatments to improve DS phenotypes. Trisomy of Dyrk1a, a gene on human chromosome 21, has been linked to DS cognitive, skeletal, and craniofacial deficits. Epigallocatechin gallate (EGCG), the major polyphenol in green tea, inhibits Dyrk1a activity in vitro, fueling the hypothesis that EGCG treatment would improve DS phenotypes. Outcomes from various treatments in DS mouse models or humans with DS have been mixed, and evidence showing EGCG acts via inhibition of Dyrk1a in vivo is lacking. If EGCG is to be a rational treatment for DS, additional evidence must identify the role of elevated Dyrk1a activity in DS phenotypes, and show that EGCG treatment produces tissue levels sufficient to inhibit Dyrk1a activity in vivo that is temporally correlated with its efficacy." @default.
• W2893907400 created "2018-10-05" @default.
• W2893907400 creator A5028748846 @default.
• W2893907400 creator A5053485083 @default.
• W2893907400 date "2018-01-01" @default.
• W2893907400 modified "2023-09-26" @default.
• W2893907400 title "Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?" @default.
• W2893907400 cites W1481530665 @default.
• W2893907400 cites W1497218644 @default.
• W2893907400 cites W1751673191 @default.
• W2893907400 cites W1844257758 @default.
• W2893907400 cites W1900601199 @default.
• W2893907400 cites W1929467545 @default.
• W2893907400 cites W1964178482 @default.
• W2893907400 cites W1964683842 @default.
• W2893907400 cites W1969554270 @default.
• W2893907400 cites W1970501621 @default.
• W2893907400 cites W1978849306 @default.
• W2893907400 cites W1982306645 @default.
• W2893907400 cites W1986503994 @default.
• W2893907400 cites W1987510426 @default.
• W2893907400 cites W1987571337 @default.
• W2893907400 cites W1990400261 @default.
• W2893907400 cites W1996482475 @default.
• W2893907400 cites W1997381668 @default.
• W2893907400 cites W1997948920 @default.
• W2893907400 cites W2002509247 @default.
• W2893907400 cites W2006124071 @default.
• W2893907400 cites W2011588737 @default.
• W2893907400 cites W2016851176 @default.
• W2893907400 cites W2018237527 @default.
• W2893907400 cites W2018945229 @default.
• W2893907400 cites W2030669013 @default.
• W2893907400 cites W2034475576 @default.
• W2893907400 cites W2036591798 @default.
• W2893907400 cites W2042916026 @default.
• W2893907400 cites W2046822015 @default.
• W2893907400 cites W2047709977 @default.
• W2893907400 cites W2050903035 @default.
• W2893907400 cites W2051065236 @default.
• W2893907400 cites W2051685982 @default.
• W2893907400 cites W2055228823 @default.
• W2893907400 cites W2056538157 @default.
• W2893907400 cites W2058257681 @default.
• W2893907400 cites W2060241396 @default.
• W2893907400 cites W2072016376 @default.
• W2893907400 cites W2072930008 @default.
• W2893907400 cites W2073374252 @default.
• W2893907400 cites W2077273976 @default.
• W2893907400 cites W2079765578 @default.
• W2893907400 cites W2082980172 @default.
• W2893907400 cites W2084233122 @default.
• W2893907400 cites W2085790004 @default.
• W2893907400 cites W2088136720 @default.
• W2893907400 cites W2094573922 @default.
• W2893907400 cites W2105509736 @default.
• W2893907400 cites W2110646442 @default.
• W2893907400 cites W2111942361 @default.
• W2893907400 cites W2112197800 @default.
• W2893907400 cites W2116219489 @default.
• W2893907400 cites W2116247013 @default.
• W2893907400 cites W2117152239 @default.
• W2893907400 cites W2126559811 @default.
• W2893907400 cites W2132156090 @default.
• W2893907400 cites W2137001273 @default.
• W2893907400 cites W2141008235 @default.
• W2893907400 cites W2142405661 @default.
• W2893907400 cites W2144835441 @default.
• W2893907400 cites W2146113273 @default.
• W2893907400 cites W2149852014 @default.
• W2893907400 cites W2151327886 @default.
• W2893907400 cites W2154849502 @default.
• W2893907400 cites W2158240118 @default.
• W2893907400 cites W2164216363 @default.
• W2893907400 cites W2166206161 @default.
• W2893907400 cites W2169926950 @default.
• W2893907400 cites W2190781699 @default.
• W2893907400 cites W2195622203 @default.
• W2893907400 cites W2228036608 @default.
• W2893907400 cites W2277264694 @default.
• W2893907400 cites W2293284325 @default.
• W2893907400 cites W2303984800 @default.
• W2893907400 cites W2347208728 @default.
• W2893907400 cites W2413465592 @default.
• W2893907400 cites W2468259612 @default.
• W2893907400 cites W2503687478 @default.
• W2893907400 cites W2507240154 @default.
• W2893907400 cites W2532068730 @default.
• W2893907400 cites W2547565291 @default.
• W2893907400 cites W2561475925 @default.
• W2893907400 cites W2592667503 @default.
• W2893907400 cites W2601070421 @default.
• W2893907400 cites W2610860635 @default.
• W2893907400 cites W2697000055 @default.
• W2893907400 cites W2754534244 @default.
• W2893907400 cites W2783476402 @default.
• W2893907400 cites W4240162654 @default.
• W2893907400 cites W69577330 @default.

• next