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• W2893917847 abstract "MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors." @default.
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• W2893917847 date "2018-09-25" @default.
• W2893917847 modified "2023-10-07" @default.
• W2893917847 title "The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells" @default.
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• W2893917847 doi "https://doi.org/10.1101/gad.313007.118" @default.
• W2893917847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6169836" @default.
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