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• W2893920992 abstract "Actinobaculum massiliense, a Gram-positive anaerobic coccoid rod colonizing the human urinary tract, belongs to the taxonomic class of Actinobacteria. We identified A. massiliense as a cohabitant of urethral catheter biofilms (CB). The CBs also harbored more common uropathogens, such as Proteus mirabilis and Aerococcus urinae, supporting the notion that A. massiliense is adapted to a life style in polymicrobial biofilms. We isolated a clinical strain from a blood agar colony and used 16S rRNA gene sequencing and shotgun proteomics to confirm its identity as A. massiliense. We characterized this species by quantitatively comparing the bacterial proteome derived from in vitro growth with that of four clinical samples. The functional relevance of proteins with emphasis on nutrient import and the response to hostile host conditions, showing evidence of neutrophil infiltration, was analyzed. Two putative subtilisin-like proteases and a heme/oligopeptide transporter were abundant in vivo and are likely important for survival and fitness in the biofilm. Proteins facilitating uptake of xylose/glucuronate and oligopeptides, also highly expressed in vivo, may feed metabolites into mixed acid fermentation and peptidolysis pathways, respectively, to generate energy. A polyketide synthase predicted to generate a secondary metabolite that interacts with either the human host or co-colonizing microbes was also identified. The product of the PKS enzyme may contribute to A. massiliense fitness and persistence in the CBs." @default.
• W2893920992 created "2018-10-05" @default.
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• W2893920992 date "2018-12-09" @default.
• W2893920992 modified "2023-09-27" @default.
• W2893920992 title "Actinobaculum massiliense Proteome Profiled in Polymicrobial Urethral Catheter Biofilms" @default.
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• W2893920992 doi "https://doi.org/10.3390/proteomes6040052" @default.
• W2893920992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6314084" @default.
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• W2893920992 hasPublicationYear "2018" @default.
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