FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893923669> ?p ?o ?g. }

• W2893923669 endingPage "2947" @default.
• W2893923669 startingPage "2947" @default.
• W2893923669 abstract "In this study, we investigated the effects of minocycline, a putative suppressor of microglial activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation, allodynia, and hyperalgesia in neonatal rats. Intraperitoneal (i.p.) injection of LPS (2 mg/kg) or sterile saline was performed in postnatal day 5 (P5) rat pups and minocycline (45 mg/kg) or vehicle (phosphate buffer saline; PBS) was administered (i.p.) 5 min after LPS injection. The von Frey filament and tail-flick tests were performed to determine mechanical allodynia (a painful sensation caused by innocuous stimuli, e.g., light touch) and thermal hyperalgesia (a condition of altered perception of temperature), respectively, and spinal cord inflammation was examined 24 h after the administration of drugs. Systemic LPS administration resulted in a reduction of tactile threshold in the von Frey filament tests and pain response latency in the tail-flick test of neonatal rats. The levels of microglia and astrocyte activation, pro-inflammatory cytokine interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in the spinal cord of neonatal rats were increased 24 h after the administration of LPS. Treatment with minocycline significantly attenuated LPS-induced allodynia, hyperalgesia, the increase in spinal cord microglia, and astrocyte activation, and elevated levels of IL-1β, COX-2, and PGE2 in neonatal rats. These results suggest that minocycline provides protection against neonatal systemic LPS exposure-induced enhanced pain sensitivity (allodynia and hyperalgesia), and that the protective effects may be associated with its ability to attenuate LPS-induced microglia activation, and the levels of IL-1β, COX-2, and PGE2 in the spinal cord of neonatal rats." @default.
• W2893923669 created "2018-10-05" @default.
• W2893923669 creator A5022250322 @default.
• W2893923669 creator A5036671092 @default.
• W2893923669 creator A5044230815 @default.
• W2893923669 creator A5045111032 @default.
• W2893923669 creator A5048044957 @default.
• W2893923669 creator A5063743190 @default.
• W2893923669 creator A5082610318 @default.
• W2893923669 date "2018-09-27" @default.
• W2893923669 modified "2023-09-26" @default.
• W2893923669 title "Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats" @default.
• W2893923669 cites W118412131 @default.
• W2893923669 cites W1589594364 @default.
• W2893923669 cites W1621611931 @default.
• W2893923669 cites W1630626183 @default.
• W2893923669 cites W1848552725 @default.
• W2893923669 cites W1965245442 @default.
• W2893923669 cites W1967693560 @default.
• W2893923669 cites W1969773497 @default.
• W2893923669 cites W1970918436 @default.
• W2893923669 cites W1978958738 @default.
• W2893923669 cites W1985367066 @default.
• W2893923669 cites W1990445317 @default.
• W2893923669 cites W1993783928 @default.
• W2893923669 cites W2000133612 @default.
• W2893923669 cites W2003438800 @default.
• W2893923669 cites W2004371769 @default.
• W2893923669 cites W2010222731 @default.
• W2893923669 cites W2015157276 @default.
• W2893923669 cites W2015756509 @default.
• W2893923669 cites W2017975056 @default.
• W2893923669 cites W2019208784 @default.
• W2893923669 cites W2022381785 @default.
• W2893923669 cites W2024662441 @default.
• W2893923669 cites W2027731569 @default.
• W2893923669 cites W2028521977 @default.
• W2893923669 cites W2030204659 @default.
• W2893923669 cites W2033715816 @default.
• W2893923669 cites W2035455618 @default.
• W2893923669 cites W2039928597 @default.
• W2893923669 cites W2041806735 @default.
• W2893923669 cites W2050560667 @default.
• W2893923669 cites W2055750901 @default.
• W2893923669 cites W2056801474 @default.
• W2893923669 cites W2063885093 @default.
• W2893923669 cites W2068872768 @default.
• W2893923669 cites W2074661552 @default.
• W2893923669 cites W2077885131 @default.
• W2893923669 cites W2082855343 @default.
• W2893923669 cites W2085508168 @default.
• W2893923669 cites W2087214422 @default.
• W2893923669 cites W2094880231 @default.
• W2893923669 cites W2095676088 @default.
• W2893923669 cites W2097281218 @default.
• W2893923669 cites W2101882302 @default.
• W2893923669 cites W2111964682 @default.
• W2893923669 cites W2112774187 @default.
• W2893923669 cites W2117622133 @default.
• W2893923669 cites W2117876803 @default.
• W2893923669 cites W2122348000 @default.
• W2893923669 cites W2122802155 @default.
• W2893923669 cites W2127854743 @default.
• W2893923669 cites W2131820270 @default.
• W2893923669 cites W2133316133 @default.
• W2893923669 cites W2133961780 @default.
• W2893923669 cites W2134557769 @default.
• W2893923669 cites W2138637179 @default.
• W2893923669 cites W2140441724 @default.
• W2893923669 cites W2142100398 @default.
• W2893923669 cites W2145938600 @default.
• W2893923669 cites W2147830608 @default.
• W2893923669 cites W2149365742 @default.
• W2893923669 cites W2153038714 @default.
• W2893923669 cites W2155368784 @default.
• W2893923669 cites W2157587576 @default.
• W2893923669 cites W2158172497 @default.
• W2893923669 cites W2171352532 @default.
• W2893923669 cites W2172582439 @default.
• W2893923669 cites W2400602733 @default.
• W2893923669 cites W2569818201 @default.
• W2893923669 doi "https://doi.org/10.3390/ijms19102947" @default.
• W2893923669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6212885" @default.
• W2893923669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30262747" @default.
• W2893923669 hasPublicationYear "2018" @default.
• W2893923669 type Work @default.
• W2893923669 sameAs 2893923669 @default.
• W2893923669 citedByCount "22" @default.
• W2893923669 countsByYear W28939236692019 @default.
• W2893923669 countsByYear W28939236692020 @default.
• W2893923669 countsByYear W28939236692021 @default.
• W2893923669 countsByYear W28939236692022 @default.
• W2893923669 countsByYear W28939236692023 @default.
• W2893923669 crossrefType "journal-article" @default.
• W2893923669 hasAuthorship W2893923669A5022250322 @default.
• W2893923669 hasAuthorship W2893923669A5036671092 @default.
• W2893923669 hasAuthorship W2893923669A5044230815 @default.
• W2893923669 hasAuthorship W2893923669A5045111032 @default.

• next