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- W2893924863 abstract "In this work, an electroanalytical method adopted for determination of Emtricitabine (EMT) using cyclic and linear sweep voltametry (CV and LSV) on gold (Au dia. 3 mm) disc electrode in 0.5 M KOH as a supporting electrolyte is developed. It is found that the oxidation process is irreversible over a wider pH range and exhibited linear diffusion-controlled behaviour. EMT exhibits a signal at 0.51 V vs SCE corresponding to oxidation of EMT in 0.5 M KOH on the Au disc electrode. Furthermore, CV and LSV were used to determine electroanalytical parameters like the limit of detection of 0.7069 (LOD), limit of quantification 2.35 (LOQ), sensitivity 0.60 μA mM−1 cm−2, the effect of accumulation, change in pH, sweep rate and effect of concentration (0.001–100 mM) on the stability (less than 5 % potential and current) of the signal. Further stability studies were carried out by monitoring the response on adding some other common biologically active excipients. Additionally, the antimicrobial activity of pristine EMT and its oxidative product shows significant enhancement after oxidative conversion. This work may thus open the door for the design of electrochemical methods for the electrochemical detection followed by determination of various electroanalytical parameters of drug molecules along with their electrochemical conversion to more active forms with comparatively enhanced biological activity. The presented results are reflecting the significant environmental and clinical importance of the presented approach." @default.
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- W2893924863 date "2018-11-07" @default.
- W2893924863 modified "2023-09-25" @default.
- W2893924863 title "Electrochemical Studies of Anti‐HIV Drug Emtricitabine: Oxidative Determination and Improved Antimicrobial Activity" @default.
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- W2893924863 doi "https://doi.org/10.1002/celc.201801228" @default.
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