Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893932691> ?p ?o ?g. }
- W2893932691 abstract "We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the guanylyl cyclases (GCs) and the sodium/calcium-potassium exchangers (NCKXs). We identified a paralogon containing at least 36 phototransduction genes from at least fourteen families, including all four of the families involved in the Ca-feedback loop (recoverin/visinin, GCAPs, GCs and NCKXs). By combining analyses of gene synteny with analyses of the molecular phylogeny for each of these four families of genes for Ca-feedback regulation, we have established the likely pattern of gene duplications and losses underlying the expansion of isoforms, both before and during the two rounds of whole-genome duplication (2R WGD) that occurred in early vertebrate evolution. Furthermore, by combining our results with earlier evidence on the timing of duplication of the visual G-protein receptor kinase genes, we propose that specialization of proto-vertebrate photoreceptor cells for operation at high and low light intensities preceded the emergence of rhodopsin, which occurred during 2R WGD." @default.
- W2893932691 created "2018-10-05" @default.
- W2893932691 creator A5038840061 @default.
- W2893932691 creator A5074274548 @default.
- W2893932691 date "2018-09-01" @default.
- W2893932691 modified "2023-10-12" @default.
- W2893932691 title "Evolution of the calcium feedback steps of vertebrate phototransduction" @default.
- W2893932691 cites W1531417601 @default.
- W2893932691 cites W1544329852 @default.
- W2893932691 cites W1544903829 @default.
- W2893932691 cites W1593641648 @default.
- W2893932691 cites W1928477457 @default.
- W2893932691 cites W1938954334 @default.
- W2893932691 cites W1965552527 @default.
- W2893932691 cites W1966412526 @default.
- W2893932691 cites W1969971056 @default.
- W2893932691 cites W1970070873 @default.
- W2893932691 cites W1973121755 @default.
- W2893932691 cites W1973709014 @default.
- W2893932691 cites W1974191268 @default.
- W2893932691 cites W1977571897 @default.
- W2893932691 cites W1983102293 @default.
- W2893932691 cites W1987182065 @default.
- W2893932691 cites W1988127541 @default.
- W2893932691 cites W1988297454 @default.
- W2893932691 cites W1998029597 @default.
- W2893932691 cites W1998625959 @default.
- W2893932691 cites W1999354994 @default.
- W2893932691 cites W2004697473 @default.
- W2893932691 cites W2008166774 @default.
- W2893932691 cites W2008703226 @default.
- W2893932691 cites W2009106846 @default.
- W2893932691 cites W2016000389 @default.
- W2893932691 cites W2019527106 @default.
- W2893932691 cites W2020295187 @default.
- W2893932691 cites W2022425508 @default.
- W2893932691 cites W2024814492 @default.
- W2893932691 cites W2033340443 @default.
- W2893932691 cites W2039114407 @default.
- W2893932691 cites W2043408047 @default.
- W2893932691 cites W2045519476 @default.
- W2893932691 cites W2048264536 @default.
- W2893932691 cites W2051161693 @default.
- W2893932691 cites W2053204895 @default.
- W2893932691 cites W2062018285 @default.
- W2893932691 cites W2066181699 @default.
- W2893932691 cites W2067151523 @default.
- W2893932691 cites W2067778076 @default.
- W2893932691 cites W2068101913 @default.
- W2893932691 cites W2069018128 @default.
- W2893932691 cites W2081311184 @default.
- W2893932691 cites W2085514362 @default.
- W2893932691 cites W2089386102 @default.
- W2893932691 cites W2090336760 @default.
- W2893932691 cites W2091000566 @default.
- W2893932691 cites W2091258587 @default.
- W2893932691 cites W2097999639 @default.
- W2893932691 cites W2098316561 @default.
- W2893932691 cites W2105129317 @default.
- W2893932691 cites W2111647009 @default.
- W2893932691 cites W2122755287 @default.
- W2893932691 cites W2124425523 @default.
- W2893932691 cites W2134675152 @default.
- W2893932691 cites W2141147107 @default.
- W2893932691 cites W2141431840 @default.
- W2893932691 cites W2144312527 @default.
- W2893932691 cites W2147461064 @default.
- W2893932691 cites W2149525061 @default.
- W2893932691 cites W2150270014 @default.
- W2893932691 cites W2150831428 @default.
- W2893932691 cites W2154179345 @default.
- W2893932691 cites W2155922552 @default.
- W2893932691 cites W2161318689 @default.
- W2893932691 cites W2161802912 @default.
- W2893932691 cites W2163627198 @default.
- W2893932691 cites W2165170253 @default.
- W2893932691 cites W2188354508 @default.
- W2893932691 cites W2299074704 @default.
- W2893932691 cites W2319350696 @default.
- W2893932691 cites W2355837210 @default.
- W2893932691 cites W2409249472 @default.
- W2893932691 cites W2412751662 @default.
- W2893932691 cites W2424086837 @default.
- W2893932691 cites W2548784423 @default.
- W2893932691 cites W2601877725 @default.
- W2893932691 cites W2784136508 @default.
- W2893932691 cites W2793858787 @default.
- W2893932691 cites W2892608743 @default.
- W2893932691 cites W324761896 @default.
- W2893932691 cites W4229487902 @default.
- W2893932691 cites W47208518 @default.
- W2893932691 doi "https://doi.org/10.1098/rsob.180119" @default.
- W2893932691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170504" @default.
- W2893932691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257895" @default.
- W2893932691 hasPublicationYear "2018" @default.
- W2893932691 type Work @default.
- W2893932691 sameAs 2893932691 @default.
- W2893932691 citedByCount "10" @default.
- W2893932691 countsByYear W28939326912018 @default.
- W2893932691 countsByYear W28939326912020 @default.