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- W2893933306 abstract "The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through a codon-specific regulation of HIF1α mRNA translation. Moreover, depletion of U34-enzymes resensitizes resistant melanoma to targeted therapy. These results indicate that targeting U34-enzymes represents a new therapeutic opportunity for melanoma patients." @default.
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- W2893933306 date "2018-09-25" @default.
- W2893933306 modified "2023-10-18" @default.
- W2893933306 title "Wobble uridine tRNA modification: a new vulnerability of refractory melanoma" @default.
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- W2893933306 doi "https://doi.org/10.1080/23723556.2018.1513725" @default.
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