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- W2893934446 abstract "2844 Potent adjuvants are key to successful vaccination against weakly immunogenic antigens such as those involved in cancer or chronic infection. In particular, agents that can recruit and activate dendritic cells (DC) in vivo may enhance immune responses generated during active immunization. We evaluated the adjuvant effects of the TLR7 agonist imiquimod as compared with GM-CSF, which has been widely used as a vaccine adjuvant. Topical imiquimod elicited a profound inflammatory infiltrate at the application site. Although both topical imiquimod and intradermal GM-CSF as adjuvant effectively induced the accumulation and activation of DC in draining lymph nodes (DLN), imiquimod preferentially stimulated the accumulation of skin Langerhans cells (CD11c+/CD86+/CD205+/CD8-) in DLN. The phenotypic difference in the DC mobilized by GM-CSF and imiquimod was accompanied by functional differences. Both GM-CSF and imiquimod augmented ova specific-CD4 T cell response in ova-tg mice when used in conjunction with CD4 peptide-based vaccines, as demonstrated by in vivo proliferation of CFSE labeled DO11.10 cells. Although both GM-CSF and imiquimod stimulated OVA specific CD8 T cell responses in OVA-tg mice when immunized with a CD8 peptide, the response induced by imiquimod was of greater magnitude. Finally, imiquimod was markedly more effective in stimulating ova specific T cell immunity with a protein-based vaccine as compared to GM-CSF. Thus, imiquimod is a potent vaccine adjuvant in promoting Th1 type of responses and has the potential for clinical use as a vaccine adjuvant." @default.
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- W2893934446 date "2008-05-01" @default.
- W2893934446 modified "2023-09-27" @default.
- W2893934446 title "TLR7 agonist imiquimod is a potent vaccine adjuvant" @default.
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