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- W2893937742 abstract "Abstract Proper positioning of nucleosomes in eukaryotic cells is determined by a complex interplay of factors, including nucleosome-nucleosome interactions, DNA sequence, and active chromatin remodeling. Yet, characteristic features of nucleosome positioning, such as gene-averaged nucleosome patterns, are surprisingly robust across perturbations, conditions, and species. Here, we explore how this robustness arises despite the underlying complexity. We leverage mathematical models to show that a large class of positioning mechanisms merely affects the quantitative characteristics of qualitatively robust positioning patterns. We demonstrate how statistical positioning emerges as an effective description from the complex interplay of different positioning mechanisms, which ultimately only renormalize the model parameter quantifying the effective softness of nucleosomes. This renormalization can be species-specific, rationalizing a puzzling discrepancy between the effective nucleosome softness of S. pombe and S. cerevisiae. More generally, we establish a quantitative framework for dissecting the interplay of different nucleosome positioning determinants." @default.
- W2893937742 created "2018-10-05" @default.
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- W2893937742 date "2018-10-01" @default.
- W2893937742 modified "2023-09-27" @default.
- W2893937742 title "Emergence of robust nucleosome patterns from an interplay of positioning mechanisms" @default.
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- W2893937742 doi "https://doi.org/10.1101/431445" @default.
- W2893937742 hasPublicationYear "2018" @default.
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