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- W2893942188 abstract "Viruses encode multiple proteins aimed at modulating cellular homeostasis and antagonizing the host antiviral response. Most of these genes were originally acquired from the host and subsequently adapted to benefit the virus. ANK proteins are common in eukaryotes but are unusual amongst viruses, with the exception of poxviruses, where they represent one of the largest protein families. We report here the existence of a new class of viral ANK proteins, termed ANK/BC, that provide new insights into the origin of poxvirus ANK proteins. ANK/BC proteins target the host E3 ubiquitin ligase Cullin-2 via a C-terminal BC box domain and are potent suppressors of the production of inflammatory cytokines, including interferon. The existence of cellular ANK proteins whose architecture is similar suggests the acquisition of a host ANK/BC gene by an ancestral orthopoxvirus and its subsequent duplication and adaptation to widen the repertoire of immune evasion strategies." @default.
- W2893942188 created "2018-10-05" @default.
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- W2893942188 date "2018-12-01" @default.
- W2893942188 modified "2023-10-08" @default.
- W2893942188 title "Novel Class of Viral Ankyrin Proteins Targeting the Host E3 Ubiquitin Ligase Cullin-2" @default.
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- W2893942188 doi "https://doi.org/10.1128/jvi.01374-18" @default.
- W2893942188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6232478" @default.
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