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• W2893942875 abstract "Abstract Granted that neural networks are nature’s most amazing invention, what is in second place? One candidate is the human eye, and specifically its transparent lens. Here we use the evolution of the lens’ dominant proteins to quantify subtle improvements in alpha crystallins between chickens and humans. These improvements are different in α A and α B crystallins, and suggest that their functions are complementary. We relate crystallin evolution to the fiber cell structure of the eye, and its enhanced resistance to cataracts in humans, with weakened resistance in rats, which improves to elephants and finally humans. Our results show that the 2007 Brazilian hydropathicity scale based on self-organized criticality is qualitatively superior to the >100 classical scales based on protein unfolding." @default.
• W2893942875 created "2018-10-05" @default.
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• W2893942875 date "2019-01-01" @default.
• W2893942875 modified "2023-09-27" @default.
• W2893942875 title "Hydropathic wave ordering of alpha crystallin—Membrane interactions enhances human lens transparency and resists cataracts" @default.
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• W2893942875 doi "https://doi.org/10.1016/j.physa.2018.09.128" @default.
• W2893942875 hasPublicationYear "2019" @default.
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