Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893945350> ?p ?o ?g. }
- W2893945350 endingPage "765" @default.
- W2893945350 startingPage "754" @default.
- W2893945350 abstract "Objective Spinal and bulbar muscular atrophy (SBMA) is a slowly progressive disease with weakness of bulbar and extremity muscles. There is no curative treatment for the disease, but several clinical trials have been conducted over the past years. The results from these trials have uncovered a great need to develop quantitative, reliable outcome measures. In this study, we prospectively investigated disease progression over 18 months in 29 patients with genetically confirmed SBMA, using quantitative outcome measures, including Dixon magnetic resonance imaging (MRI). Methods We used MRI to assess changes in muscle fat content and stationary dynamometry to assess changes in muscle strength. Disease progression was also investigated with the SBMA functional rating scale, bulbar rating scale, 6‐minute walk test, and blood samples, among others. Results Mean muscle fat content, muscle strength in knee extensors, handgrip strength, walking distance, and creatinine levels changed significantly. Mean muscle fat content increased by 2 ± 1.25%, and knee extension strength decreased from 83 ± 60 to 76 ± 56Nm, handgrip strength from 31 ± 13 to 29 ± 13kg, walking distance from 362 ± 216 to 336 ± 219m, and creatinine level from 58 ± 21 to 54 ± 20 μmol/l. Functional rating scores did not change. Interpretation The present study demonstrates a slow and steady disease progression in SBMA. Dixon MRI detected increases in muscle fat content in all investigated muscles and is therefore a suitable candidate for an outcome measure in natural history or treatment studies in SBMA. The 6‐minute walk test and handgrip strength also seem to be reliable outcome measures for SBMA. Ann Neurol 2018;84:762–773" @default.
- W2893945350 created "2018-10-05" @default.
- W2893945350 creator A5004880821 @default.
- W2893945350 creator A5038636561 @default.
- W2893945350 creator A5045742835 @default.
- W2893945350 creator A5072916063 @default.
- W2893945350 creator A5081838739 @default.
- W2893945350 creator A5088134958 @default.
- W2893945350 date "2018-10-25" @default.
- W2893945350 modified "2023-10-17" @default.
- W2893945350 title "Disease progression and outcome measures in spinobulbar muscular atrophy" @default.
- W2893945350 cites W1861946363 @default.
- W2893945350 cites W1972782804 @default.
- W2893945350 cites W1989680636 @default.
- W2893945350 cites W1993909795 @default.
- W2893945350 cites W1997682022 @default.
- W2893945350 cites W2013452556 @default.
- W2893945350 cites W2029425568 @default.
- W2893945350 cites W2030199472 @default.
- W2893945350 cites W2049012951 @default.
- W2893945350 cites W2058580369 @default.
- W2893945350 cites W2074342599 @default.
- W2893945350 cites W2076314980 @default.
- W2893945350 cites W2086027430 @default.
- W2893945350 cites W2086240335 @default.
- W2893945350 cites W2099945729 @default.
- W2893945350 cites W2108834942 @default.
- W2893945350 cites W2114242035 @default.
- W2893945350 cites W2133563625 @default.
- W2893945350 cites W2137339327 @default.
- W2893945350 cites W2137610223 @default.
- W2893945350 cites W2154721980 @default.
- W2893945350 cites W2159162402 @default.
- W2893945350 cites W2189787157 @default.
- W2893945350 cites W2313208135 @default.
- W2893945350 cites W2408654324 @default.
- W2893945350 cites W2531415786 @default.
- W2893945350 cites W2566766381 @default.
- W2893945350 cites W2577042876 @default.
- W2893945350 cites W2607445004 @default.
- W2893945350 cites W2724098443 @default.
- W2893945350 cites W2742460030 @default.
- W2893945350 cites W2788363797 @default.
- W2893945350 cites W2790886139 @default.
- W2893945350 cites W2886211838 @default.
- W2893945350 cites W4231465480 @default.
- W2893945350 doi "https://doi.org/10.1002/ana.25345" @default.
- W2893945350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30255951" @default.
- W2893945350 hasPublicationYear "2018" @default.
- W2893945350 type Work @default.
- W2893945350 sameAs 2893945350 @default.
- W2893945350 citedByCount "16" @default.
- W2893945350 countsByYear W28939453502018 @default.
- W2893945350 countsByYear W28939453502019 @default.
- W2893945350 countsByYear W28939453502020 @default.
- W2893945350 countsByYear W28939453502021 @default.
- W2893945350 countsByYear W28939453502022 @default.
- W2893945350 countsByYear W28939453502023 @default.
- W2893945350 crossrefType "journal-article" @default.
- W2893945350 hasAuthorship W2893945350A5004880821 @default.
- W2893945350 hasAuthorship W2893945350A5038636561 @default.
- W2893945350 hasAuthorship W2893945350A5045742835 @default.
- W2893945350 hasAuthorship W2893945350A5072916063 @default.
- W2893945350 hasAuthorship W2893945350A5081838739 @default.
- W2893945350 hasAuthorship W2893945350A5088134958 @default.
- W2893945350 hasConcept C121608353 @default.
- W2893945350 hasConcept C126322002 @default.
- W2893945350 hasConcept C126838900 @default.
- W2893945350 hasConcept C138496976 @default.
- W2893945350 hasConcept C143409427 @default.
- W2893945350 hasConcept C15744967 @default.
- W2893945350 hasConcept C1862650 @default.
- W2893945350 hasConcept C2776214593 @default.
- W2893945350 hasConcept C2776263037 @default.
- W2893945350 hasConcept C2776418732 @default.
- W2893945350 hasConcept C2776635132 @default.
- W2893945350 hasConcept C2780192828 @default.
- W2893945350 hasConcept C2780434838 @default.
- W2893945350 hasConcept C2781172350 @default.
- W2893945350 hasConcept C55493867 @default.
- W2893945350 hasConcept C61367390 @default.
- W2893945350 hasConcept C71924100 @default.
- W2893945350 hasConcept C83849319 @default.
- W2893945350 hasConcept C86803240 @default.
- W2893945350 hasConcept C99508421 @default.
- W2893945350 hasConceptScore W2893945350C121608353 @default.
- W2893945350 hasConceptScore W2893945350C126322002 @default.
- W2893945350 hasConceptScore W2893945350C126838900 @default.
- W2893945350 hasConceptScore W2893945350C138496976 @default.
- W2893945350 hasConceptScore W2893945350C143409427 @default.
- W2893945350 hasConceptScore W2893945350C15744967 @default.
- W2893945350 hasConceptScore W2893945350C1862650 @default.
- W2893945350 hasConceptScore W2893945350C2776214593 @default.
- W2893945350 hasConceptScore W2893945350C2776263037 @default.
- W2893945350 hasConceptScore W2893945350C2776418732 @default.
- W2893945350 hasConceptScore W2893945350C2776635132 @default.
- W2893945350 hasConceptScore W2893945350C2780192828 @default.
- W2893945350 hasConceptScore W2893945350C2780434838 @default.