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- W2893947997 abstract "Objectives: To review the therapeutic option of Rituximab, a chimeric anti-CD20 antibody, in systemic autoimmune rheumatic diseases (SARDs) such as systemic lupus erythematosus, systemic sclerosis, primary Sjögren syndrome and idiopathic inflammatory myopathy.Methods: A non-systematic review was conducted.Results: The specific role and indication of rituximab in SARDs has been the subject of multiple trials in recent years. Evidence supports the use of rituximab in moderate-to-severe refractory systemic lupus erythematosus, diffuse skin involvement in systemic sclerosis and systemic involvement in primary Sjögren syndrome. Several guidelines have adopted these indications. In addition, there is a consensus about the use of rituximab in refractory myositis. The role of rituximab in interstitial lung disease associated with these SARDs needs to be further explored.Conclusion: Rituximab is a treatment option in several SARDs. Upcoming trials, use in daily practice and the safety profile are elaborated on." @default.
- W2893947997 created "2018-10-05" @default.
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- W2893947997 date "2018-09-26" @default.
- W2893947997 modified "2023-10-18" @default.
- W2893947997 title "Rituximab in systemic autoimmune rheumatic diseases: indications and practical use" @default.
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- W2893947997 doi "https://doi.org/10.1080/17843286.2018.1521904" @default.
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