FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893952489> ?p ?o ?g. }

• W2893952489 endingPage "275" @default.
• W2893952489 startingPage "262" @default.
• W2893952489 abstract "Chronic wounds pose a stern challenge to health care systems with growing incidence especially in the aged population. In the presence of increased iron concentrations, recruitment of monocytes from the circulation and activation towards ROS and RNS releasing M1 macrophages together with the persistence of senescent fibroblasts at the wound site are significantly enhanced. This unrestrained activation of pro-inflammatory macrophages and senescent fibroblasts has increasingly been acknowledged as main driver causing non-healing wounds. In a metaphor, macrophages act like stage directors of wound healing, resident fibroblasts constitute main actors and increased iron concentrations are decisive parts of the libretto, and – if dysregulated – are responsible for the development of non-healing wounds. This review will focus on recent cellular and molecular findings from chronic venous leg ulcers and diabetic non-healing wounds both constituting the most common pathologies often resulting in limb amputations of patients. This not only causes tremendous suffering and loss of life quality, but is also associated with an increase in mortality and a major socio-economic burden. Despite recent advances, the underlying molecular mechanisms are not completely understood. Overwhelming evidence shows that reactive oxygen species and the transition metal and trace element iron at pathological concentrations are crucially involved in a complex interplay between cells of different histogenetic origin and their extracellular niche environment. This interplay depends on a variety of cellular, non-cellular biochemical and cell biological mechanisms. Here, we will highlight recent progress in the field of iron-dependent regulation of macrophages and fibroblasts and related pathologies linked to non-healing chronic wounds." @default.
• W2893952489 created "2018-10-05" @default.
• W2893952489 creator A5008721759 @default.
• W2893952489 creator A5011060521 @default.
• W2893952489 creator A5037235635 @default.
• W2893952489 creator A5062531116 @default.
• W2893952489 creator A5082555288 @default.
• W2893952489 date "2019-03-01" @default.
• W2893952489 modified "2023-10-18" @default.
• W2893952489 title "Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds" @default.
• W2893952489 cites W1514537538 @default.
• W2893952489 cites W1523617147 @default.
• W2893952489 cites W1542007198 @default.
• W2893952489 cites W1608366086 @default.
• W2893952489 cites W1723013642 @default.
• W2893952489 cites W1791493718 @default.
• W2893952489 cites W1794314584 @default.
• W2893952489 cites W1850554865 @default.
• W2893952489 cites W1904404779 @default.
• W2893952489 cites W1906626576 @default.
• W2893952489 cites W1920534265 @default.
• W2893952489 cites W1966200750 @default.
• W2893952489 cites W1967017135 @default.
• W2893952489 cites W1973530425 @default.
• W2893952489 cites W1974481403 @default.
• W2893952489 cites W1975548302 @default.
• W2893952489 cites W1976141939 @default.
• W2893952489 cites W1976428700 @default.
• W2893952489 cites W1977362098 @default.
• W2893952489 cites W1977556024 @default.
• W2893952489 cites W1978262131 @default.
• W2893952489 cites W1978491332 @default.
• W2893952489 cites W1982789137 @default.
• W2893952489 cites W1985058433 @default.
• W2893952489 cites W1987876453 @default.
• W2893952489 cites W1988830115 @default.
• W2893952489 cites W1989388426 @default.
• W2893952489 cites W1991952977 @default.
• W2893952489 cites W1992740290 @default.
• W2893952489 cites W1999482608 @default.
• W2893952489 cites W2000229809 @default.
• W2893952489 cites W2002629222 @default.
• W2893952489 cites W2003461031 @default.
• W2893952489 cites W2003764905 @default.
• W2893952489 cites W2004604872 @default.
• W2893952489 cites W2006016787 @default.
• W2893952489 cites W2007636933 @default.
• W2893952489 cites W2011569383 @default.
• W2893952489 cites W2012461405 @default.
• W2893952489 cites W2012656874 @default.
• W2893952489 cites W2015375238 @default.
• W2893952489 cites W2016279534 @default.
• W2893952489 cites W2018258390 @default.
• W2893952489 cites W2019583561 @default.
• W2893952489 cites W2020712259 @default.
• W2893952489 cites W2023237311 @default.
• W2893952489 cites W2028543411 @default.
• W2893952489 cites W2034166961 @default.
• W2893952489 cites W2035391309 @default.
• W2893952489 cites W2036246700 @default.
• W2893952489 cites W2036263091 @default.
• W2893952489 cites W2036736332 @default.
• W2893952489 cites W2037357453 @default.
• W2893952489 cites W2037675339 @default.
• W2893952489 cites W2038331116 @default.
• W2893952489 cites W2040836333 @default.
• W2893952489 cites W2043227348 @default.
• W2893952489 cites W2046687693 @default.
• W2893952489 cites W2048753210 @default.
• W2893952489 cites W2051019986 @default.
• W2893952489 cites W2055796980 @default.
• W2893952489 cites W2057864569 @default.
• W2893952489 cites W2059960043 @default.
• W2893952489 cites W2061684338 @default.
• W2893952489 cites W2062107099 @default.
• W2893952489 cites W2065086774 @default.
• W2893952489 cites W2069332674 @default.
• W2893952489 cites W2071894609 @default.
• W2893952489 cites W2072462631 @default.
• W2893952489 cites W2073759014 @default.
• W2893952489 cites W2073908835 @default.
• W2893952489 cites W2076452290 @default.
• W2893952489 cites W2079238808 @default.
• W2893952489 cites W2082793902 @default.
• W2893952489 cites W2085293124 @default.
• W2893952489 cites W2088566849 @default.
• W2893952489 cites W2090067193 @default.
• W2893952489 cites W2090834142 @default.
• W2893952489 cites W2095132685 @default.
• W2893952489 cites W2095941181 @default.
• W2893952489 cites W2103957643 @default.
• W2893952489 cites W2104908670 @default.
• W2893952489 cites W2110028093 @default.
• W2893952489 cites W2110231257 @default.
• W2893952489 cites W2121659945 @default.
• W2893952489 cites W2123960644 @default.
• W2893952489 cites W2126294104 @default.
• W2893952489 cites W2126525177 @default.

• next