Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893957465> ?p ?o ?g. }
- W2893957465 endingPage "131" @default.
- W2893957465 startingPage "126" @default.
- W2893957465 abstract "Antigens (or their epitopes)-carrier protein combinations are extensively utilized for vaccine development strategies. Chemical conjugation methods are cumbersome with limited conjugation sites. Computational protein modelling methods can evaluate every position of a carrier protein for conjugation via epitope grafting in a reasonable time frame as compared to wet experimental techniques. Graftibility of positions can be estimated by the presence of native atomic contacts in resulting chimeric antigen. Five epitopes were selected, and computational grafting at each position was performed in three templates of serum albumin. Protein modelling algorithms such as segment matching and satisfaction of spatial restraints were employed for computational grafting. Contact-based protein discriminatory function was used to evaluate the chimeric proteins having native atomic contacts. On the evaluation of approximately 1 million distinct protein modelling simulations, region around the 450th position of serum albumin was observed to be suitable for epitope grafting. Computational protein modelling tools may be used to design a chimeric antigen. The approach may overcome the limitations associated with chemical conjugation and furthermore harness the potential of custom gene synthesis/recombinant protein production." @default.
- W2893957465 created "2018-10-05" @default.
- W2893957465 creator A5027723382 @default.
- W2893957465 creator A5048481956 @default.
- W2893957465 date "2018-11-01" @default.
- W2893957465 modified "2023-10-14" @default.
- W2893957465 title "Studies on computational grafting of malarial epitopes in serum albumin" @default.
- W2893957465 cites W1607931568 @default.
- W2893957465 cites W1796116693 @default.
- W2893957465 cites W1822718834 @default.
- W2893957465 cites W1982139182 @default.
- W2893957465 cites W2002568336 @default.
- W2893957465 cites W200540413 @default.
- W2893957465 cites W2027088291 @default.
- W2893957465 cites W2028339001 @default.
- W2893957465 cites W2035867359 @default.
- W2893957465 cites W2037527898 @default.
- W2893957465 cites W2040299410 @default.
- W2893957465 cites W2052277371 @default.
- W2893957465 cites W2052350794 @default.
- W2893957465 cites W2054392131 @default.
- W2893957465 cites W2060003282 @default.
- W2893957465 cites W2065283382 @default.
- W2893957465 cites W2072263054 @default.
- W2893957465 cites W2083766934 @default.
- W2893957465 cites W2100816913 @default.
- W2893957465 cites W2101982331 @default.
- W2893957465 cites W2105189356 @default.
- W2893957465 cites W2106648157 @default.
- W2893957465 cites W2109339916 @default.
- W2893957465 cites W2127322768 @default.
- W2893957465 cites W2128082322 @default.
- W2893957465 cites W2130479394 @default.
- W2893957465 cites W2132629607 @default.
- W2893957465 cites W2134000651 @default.
- W2893957465 cites W2139915497 @default.
- W2893957465 cites W2142106325 @default.
- W2893957465 cites W2143626353 @default.
- W2893957465 cites W2145358391 @default.
- W2893957465 cites W2157165549 @default.
- W2893957465 cites W2161609692 @default.
- W2893957465 cites W2161776897 @default.
- W2893957465 cites W2166740197 @default.
- W2893957465 cites W2169458910 @default.
- W2893957465 cites W2385735394 @default.
- W2893957465 cites W2397293145 @default.
- W2893957465 cites W2557644643 @default.
- W2893957465 cites W2605068739 @default.
- W2893957465 cites W4240895940 @default.
- W2893957465 cites W852950976 @default.
- W2893957465 doi "https://doi.org/10.1016/j.compbiomed.2018.09.018" @default.
- W2893957465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30268977" @default.
- W2893957465 hasPublicationYear "2018" @default.
- W2893957465 type Work @default.
- W2893957465 sameAs 2893957465 @default.
- W2893957465 citedByCount "2" @default.
- W2893957465 countsByYear W28939574652019 @default.
- W2893957465 countsByYear W28939574652023 @default.
- W2893957465 crossrefType "journal-article" @default.
- W2893957465 hasAuthorship W2893957465A5027723382 @default.
- W2893957465 hasAuthorship W2893957465A5048481956 @default.
- W2893957465 hasConcept C104317684 @default.
- W2893957465 hasConcept C123894998 @default.
- W2893957465 hasConcept C147483822 @default.
- W2893957465 hasConcept C165616093 @default.
- W2893957465 hasConcept C178790620 @default.
- W2893957465 hasConcept C185592680 @default.
- W2893957465 hasConcept C195616568 @default.
- W2893957465 hasConcept C203014093 @default.
- W2893957465 hasConcept C2775937945 @default.
- W2893957465 hasConcept C40767141 @default.
- W2893957465 hasConcept C41008148 @default.
- W2893957465 hasConcept C521977710 @default.
- W2893957465 hasConcept C55493867 @default.
- W2893957465 hasConcept C70721500 @default.
- W2893957465 hasConcept C86803240 @default.
- W2893957465 hasConceptScore W2893957465C104317684 @default.
- W2893957465 hasConceptScore W2893957465C123894998 @default.
- W2893957465 hasConceptScore W2893957465C147483822 @default.
- W2893957465 hasConceptScore W2893957465C165616093 @default.
- W2893957465 hasConceptScore W2893957465C178790620 @default.
- W2893957465 hasConceptScore W2893957465C185592680 @default.
- W2893957465 hasConceptScore W2893957465C195616568 @default.
- W2893957465 hasConceptScore W2893957465C203014093 @default.
- W2893957465 hasConceptScore W2893957465C2775937945 @default.
- W2893957465 hasConceptScore W2893957465C40767141 @default.
- W2893957465 hasConceptScore W2893957465C41008148 @default.
- W2893957465 hasConceptScore W2893957465C521977710 @default.
- W2893957465 hasConceptScore W2893957465C55493867 @default.
- W2893957465 hasConceptScore W2893957465C70721500 @default.
- W2893957465 hasConceptScore W2893957465C86803240 @default.
- W2893957465 hasFunder F4320334771 @default.
- W2893957465 hasLocation W28939574651 @default.
- W2893957465 hasLocation W28939574652 @default.
- W2893957465 hasOpenAccess W2893957465 @default.
- W2893957465 hasPrimaryLocation W28939574651 @default.
- W2893957465 hasRelatedWork W1971002732 @default.
- W2893957465 hasRelatedWork W1979686790 @default.