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- W2893964412 abstract "Recurrent gene mutations have been described with varying frequencies in myelodysplasia (MDS) /myeloproliferative neoplasm (MPN) overlap syndromes (MMOS). Recent work has placed significant focus on understanding the role of gene lesions involving the spliceosomal machinery in leukemogeneis. SRSF2 is a gene encoding critical spliceosomal proteins. SRSF2 mutations appear to play an important role in pathogenesis of MMOS, particularly in chronic myelomonocytic leukemia. Inhibition of splicing may be a new therapeutic approach. E7107, a spliceosome inhibitor, has been shown to differentially inhibit splicing more in SRSF2-mutant cells leading to decreased leukemia burden in mice. H3B-8800 is a small molecule modulator of spliceosome complex and has been shown to lower leukemia burden in SRSF2-P95H mutant mice. This review focuses on the incidence of mutant SRSF2 across various MMOS as well as recent clinical development of spliceosome inhibitors." @default.
- W2893964412 created "2018-10-05" @default.
- W2893964412 creator A5038549488 @default.
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- W2893964412 creator A5052008214 @default.
- W2893964412 creator A5064911424 @default.
- W2893964412 creator A5072649014 @default.
- W2893964412 date "2018-09-26" @default.
- W2893964412 modified "2023-10-02" @default.
- W2893964412 title "SRSF2 mutations in myelodysplasia/myeloproliferative neoplasms" @default.
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- W2893964412 doi "https://doi.org/10.1186/s40364-018-0142-y" @default.
- W2893964412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158887" @default.
- W2893964412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30275952" @default.
- W2893964412 hasPublicationYear "2018" @default.
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