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• W2893969090 abstract "Hyperandrogenemia plays a critical role in reproductive and metabolic function in females and is the hallmark of polycystic ovary syndrome. Developing a lean PCOS-like mouse model that mimics women with PCOS is clinically meaningful. In this protocol, we describe such a model. By inserting a 4 mm length of DHT (dihydrotestosterone) crystal powder pellet (total length of pellet is 8 mm), and replacing it monthly, we are able to produce a PCOS-like mouse model with serum DHT levels 2 fold higher than mice not implanted with DHT (no-DHT). We observed reproductive and metabolic dysfunction without changing body weight and body composition. While exhibiting a high degree of infertility, a small subset of these PCOS-like female mice can get pregnant and their offspring show delayed puberty and increased testosterone as adults. This PCOS-like lean mouse model is a useful tool to study the pathophysiology of PCOS and the offspring from these PCOS-like dams." @default.
• W2893969090 created "2018-10-05" @default.
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• W2893969090 date "2018-10-02" @default.
• W2893969090 modified "2023-10-17" @default.
• W2893969090 title "A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome" @default.
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• W2893969090 doi "https://doi.org/10.3791/58379" @default.
• W2893969090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6235414" @default.
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• W2893969090 hasPublicationYear "2018" @default.
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