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- W2893973202 abstract "Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence indicates that oxytocin enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle, suggesting that dysfunction of the oxytocin system could underlie the pathogenesis of insulin resistance and dyslipidaemia. Murine studies revealed that deficiencies in oxytocin signalling and oxytocin receptor expression lead to obesity despite normal food intake, motor activity and increased leptin levels. In addition, plasma oxytocin concentration is notably lower in obese individuals with diabetes, which may suggest an involvement of the oxytocin system in the pathogenesis of cardiometabolic disease. More recently, small scale studies demonstrated that intranasal administration of oxytocin was associated with significant weight loss as well as improvements in insulin sensitivity and pancreatic β-cell responsivity in human subjects. The multi-pronged effects of oxytocin signalling on improving peripheral insulin sensitivity, pancreatic function and lipid homeostasis strongly suggest a role for this system as a therapeutic target in obesity and diabetes management. The complexity of obesity aetiology and the pathogenesis of obesity-related metabolic complications underscore the need for a systems approach to better understand the role of oxytocin in metabolic function." @default.
- W2893973202 created "2018-10-05" @default.
- W2893973202 creator A5001113261 @default.
- W2893973202 creator A5048569732 @default.
- W2893973202 creator A5068939958 @default.
- W2893973202 date "2018-09-25" @default.
- W2893973202 modified "2023-10-16" @default.
- W2893973202 title "Oxytocin in metabolic homeostasis: implications for obesity and diabetes management" @default.
- W2893973202 cites W1480143759 @default.
- W2893973202 cites W1522228430 @default.
- W2893973202 cites W1532235063 @default.
- W2893973202 cites W1541228389 @default.
- W2893973202 cites W1545777920 @default.
- W2893973202 cites W1651313486 @default.
- W2893973202 cites W1709065996 @default.
- W2893973202 cites W1750764127 @default.
- W2893973202 cites W1895522105 @default.
- W2893973202 cites W1940439926 @default.
- W2893973202 cites W1966712100 @default.
- W2893973202 cites W1969668906 @default.
- W2893973202 cites W1969679440 @default.
- W2893973202 cites W1972539146 @default.
- W2893973202 cites W1977409318 @default.
- W2893973202 cites W1979840037 @default.
- W2893973202 cites W1981648524 @default.
- W2893973202 cites W1984470734 @default.
- W2893973202 cites W1986792783 @default.
- W2893973202 cites W1986839466 @default.
- W2893973202 cites W1990832530 @default.
- W2893973202 cites W1991442212 @default.
- W2893973202 cites W1996477632 @default.
- W2893973202 cites W1996554623 @default.
- W2893973202 cites W1997612119 @default.
- W2893973202 cites W1999186303 @default.
- W2893973202 cites W2000312962 @default.
- W2893973202 cites W2008187092 @default.
- W2893973202 cites W2009865741 @default.
- W2893973202 cites W2012037560 @default.
- W2893973202 cites W2013694191 @default.
- W2893973202 cites W2015172493 @default.
- W2893973202 cites W2017136915 @default.
- W2893973202 cites W2019557263 @default.
- W2893973202 cites W2020140739 @default.
- W2893973202 cites W2023959230 @default.
- W2893973202 cites W2026444172 @default.
- W2893973202 cites W2030636706 @default.
- W2893973202 cites W2030925661 @default.
- W2893973202 cites W2032409908 @default.
- W2893973202 cites W2033476648 @default.
- W2893973202 cites W2034644036 @default.
- W2893973202 cites W2035236814 @default.
- W2893973202 cites W2037364012 @default.
- W2893973202 cites W2038145443 @default.
- W2893973202 cites W2038181972 @default.
- W2893973202 cites W2042213884 @default.
- W2893973202 cites W2046282439 @default.
- W2893973202 cites W2046829365 @default.
- W2893973202 cites W2046994812 @default.
- W2893973202 cites W2049895671 @default.
- W2893973202 cites W2050502553 @default.
- W2893973202 cites W2050590928 @default.
- W2893973202 cites W2052624720 @default.
- W2893973202 cites W2054710588 @default.
- W2893973202 cites W2057967199 @default.
- W2893973202 cites W2058634816 @default.
- W2893973202 cites W2061455531 @default.
- W2893973202 cites W2068155003 @default.
- W2893973202 cites W2068318435 @default.
- W2893973202 cites W2069333552 @default.
- W2893973202 cites W2070821979 @default.
- W2893973202 cites W2073260721 @default.
- W2893973202 cites W2075367960 @default.
- W2893973202 cites W2076652575 @default.
- W2893973202 cites W2078496789 @default.
- W2893973202 cites W2078575306 @default.
- W2893973202 cites W2078628567 @default.
- W2893973202 cites W2078628715 @default.
- W2893973202 cites W2078679760 @default.
- W2893973202 cites W2079997723 @default.
- W2893973202 cites W2082339773 @default.
- W2893973202 cites W2084632170 @default.
- W2893973202 cites W2084835891 @default.
- W2893973202 cites W2092505327 @default.
- W2893973202 cites W2094704091 @default.
- W2893973202 cites W2096250412 @default.
- W2893973202 cites W2096714527 @default.
- W2893973202 cites W2098488805 @default.
- W2893973202 cites W2100784279 @default.
- W2893973202 cites W2106733818 @default.
- W2893973202 cites W2113550500 @default.
- W2893973202 cites W2115046242 @default.
- W2893973202 cites W2115090226 @default.
- W2893973202 cites W2115138587 @default.
- W2893973202 cites W2115782404 @default.
- W2893973202 cites W2119602371 @default.
- W2893973202 cites W2120738384 @default.
- W2893973202 cites W2121284696 @default.
- W2893973202 cites W2124961114 @default.