Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893974241> ?p ?o ?g. }
- W2893974241 startingPage "433144" @default.
- W2893974241 abstract "The primary cilium is an important regulator of signaling pathways in cell proliferation and differentiation. Mechanisms involved in cilium assembly and homeostasis are well described, but little is known about mammalian ciliary disassembly, which is required for cell cycle progression. We examined whether cilia disassembly in cultured mouse cells occurred by resorption into the cell or extracellular shedding. Live cell imaging of individual disassembly events revealed dynamic and heterogeneous behaviors, with rates varying by several orders of magnitude. Surprisingly, seconds-fast disassembly was the predominant method of cilium loss (83% of events), and we demonstrate that this is due to ciliary shedding. We tested the roles of candidate regulators of ciliary shedding, katanin and intracellular calcium. Katanin overexpression increased seconds-fast disassembly, and katanin and intracellular calcium levels independently, but not synergystically, reduced cilia length. This work provides new, detailed insights into mechanisms of primary ciliary disassembly in mammalian cells." @default.
- W2893974241 created "2018-10-05" @default.
- W2893974241 creator A5035169822 @default.
- W2893974241 creator A5041641025 @default.
- W2893974241 creator A5047220841 @default.
- W2893974241 creator A5077624417 @default.
- W2893974241 date "2018-10-02" @default.
- W2893974241 modified "2023-09-25" @default.
- W2893974241 title "Heterogeneous Dynamics and Mechanisms of Primary Cilium Disassembly in Mammalian Cells" @default.
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