Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893975977> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2893975977 endingPage "587" @default.
- W2893975977 startingPage "581" @default.
- W2893975977 abstract "Herein, we report a case of a 9-yr-old girl who had a 46, XX peripheral karyotype and apparent developmentally normal ovaries. She presented with abdominal pain and a right adnexal mass. No clinical or pathologic evidence of gonadal dysgenesis or undifferentiated gonadal tissue was detected. She underwent right salpingo-oophorectomy with rupture of the tumor at the time of operation due to recent adnexal torsion. The original pathologic diagnosis was gonadoblastoma and mixed germ cell tumor. Most significantly in our study, we identified a rare and novel pathway for the development of malignant mixed germ cell tumor from gonadoblastoma in the absence of identifiable dysgerminoma. The histologically identifiable steps of progression in our case were as follows: (1) residual islands of classic gonadoblastoma, (2) overgrowth by “dissecting” gonadoblastoma composed of transformed germ cells with clear cytoplasm and sex cord elements surrounded by a basement membrane, (3) stromal infiltration by dedifferentiated germ cells with loss of basement membrane, (4) formation of malignant mixed germ cell tumor. The dedifferentiated areas were composed of anaplastic germ cells with amphophilic cytoplasm that gradually replaced the sex cord elements by clonal expansion. Both the original transformed and the anaplastic germ cell components strongly expressed OCT4. We believe that the mixed germ cell tumor arose from the dedifferentiated germ cell component through neoplastic progression. This premise suggests that the germ cell component of “dissecting” gonadoblastoma rarely undergoes anaplastic change in the absence of transition to germinoma and can be the direct precursor of mixed germ cell tumor." @default.
- W2893975977 created "2018-10-05" @default.
- W2893975977 creator A5030427478 @default.
- W2893975977 creator A5044493769 @default.
- W2893975977 creator A5091397199 @default.
- W2893975977 date "2019-11-01" @default.
- W2893975977 modified "2023-09-26" @default.
- W2893975977 title "Classic and “Dissecting” Gonadoblastoma in a Phenotypic Girl With a 46, XX Peripheral Karyotype and No Evidence of a Disorder of Sex Development" @default.
- W2893975977 cites W1514763559 @default.
- W2893975977 cites W1969580835 @default.
- W2893975977 cites W1976682319 @default.
- W2893975977 cites W1993326096 @default.
- W2893975977 cites W2006486872 @default.
- W2893975977 cites W2145361683 @default.
- W2893975977 cites W2398819523 @default.
- W2893975977 cites W2484732501 @default.
- W2893975977 cites W2607320261 @default.
- W2893975977 cites W2752296858 @default.
- W2893975977 doi "https://doi.org/10.1097/pgp.0000000000000551" @default.
- W2893975977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30252730" @default.
- W2893975977 hasPublicationYear "2019" @default.
- W2893975977 type Work @default.
- W2893975977 sameAs 2893975977 @default.
- W2893975977 citedByCount "12" @default.
- W2893975977 countsByYear W28939759772020 @default.
- W2893975977 countsByYear W28939759772021 @default.
- W2893975977 countsByYear W28939759772022 @default.
- W2893975977 countsByYear W28939759772023 @default.
- W2893975977 crossrefType "journal-article" @default.
- W2893975977 hasAuthorship W2893975977A5030427478 @default.
- W2893975977 hasAuthorship W2893975977A5044493769 @default.
- W2893975977 hasAuthorship W2893975977A5091397199 @default.
- W2893975977 hasConcept C104317684 @default.
- W2893975977 hasConcept C105702510 @default.
- W2893975977 hasConcept C134018914 @default.
- W2893975977 hasConcept C142724271 @default.
- W2893975977 hasConcept C2776252090 @default.
- W2893975977 hasConcept C2776694085 @default.
- W2893975977 hasConcept C2776938808 @default.
- W2893975977 hasConcept C2778177532 @default.
- W2893975977 hasConcept C2778324535 @default.
- W2893975977 hasConcept C2778324911 @default.
- W2893975977 hasConcept C2778895204 @default.
- W2893975977 hasConcept C2779122487 @default.
- W2893975977 hasConcept C2779272188 @default.
- W2893975977 hasConcept C29456083 @default.
- W2893975977 hasConcept C30481170 @default.
- W2893975977 hasConcept C53226629 @default.
- W2893975977 hasConcept C54355233 @default.
- W2893975977 hasConcept C71924100 @default.
- W2893975977 hasConcept C86803240 @default.
- W2893975977 hasConceptScore W2893975977C104317684 @default.
- W2893975977 hasConceptScore W2893975977C105702510 @default.
- W2893975977 hasConceptScore W2893975977C134018914 @default.
- W2893975977 hasConceptScore W2893975977C142724271 @default.
- W2893975977 hasConceptScore W2893975977C2776252090 @default.
- W2893975977 hasConceptScore W2893975977C2776694085 @default.
- W2893975977 hasConceptScore W2893975977C2776938808 @default.
- W2893975977 hasConceptScore W2893975977C2778177532 @default.
- W2893975977 hasConceptScore W2893975977C2778324535 @default.
- W2893975977 hasConceptScore W2893975977C2778324911 @default.
- W2893975977 hasConceptScore W2893975977C2778895204 @default.
- W2893975977 hasConceptScore W2893975977C2779122487 @default.
- W2893975977 hasConceptScore W2893975977C2779272188 @default.
- W2893975977 hasConceptScore W2893975977C29456083 @default.
- W2893975977 hasConceptScore W2893975977C30481170 @default.
- W2893975977 hasConceptScore W2893975977C53226629 @default.
- W2893975977 hasConceptScore W2893975977C54355233 @default.
- W2893975977 hasConceptScore W2893975977C71924100 @default.
- W2893975977 hasConceptScore W2893975977C86803240 @default.
- W2893975977 hasIssue "6" @default.
- W2893975977 hasLocation W28939759771 @default.
- W2893975977 hasLocation W28939759772 @default.
- W2893975977 hasOpenAccess W2893975977 @default.
- W2893975977 hasPrimaryLocation W28939759771 @default.
- W2893975977 hasRelatedWork W1496770721 @default.
- W2893975977 hasRelatedWork W1976416988 @default.
- W2893975977 hasRelatedWork W2045976211 @default.
- W2893975977 hasRelatedWork W2050854003 @default.
- W2893975977 hasRelatedWork W2069157449 @default.
- W2893975977 hasRelatedWork W2087603977 @default.
- W2893975977 hasRelatedWork W2405880707 @default.
- W2893975977 hasRelatedWork W2728011934 @default.
- W2893975977 hasRelatedWork W2893975977 @default.
- W2893975977 hasRelatedWork W2949895855 @default.
- W2893975977 hasVolume "38" @default.
- W2893975977 isParatext "false" @default.
- W2893975977 isRetracted "false" @default.
- W2893975977 magId "2893975977" @default.
- W2893975977 workType "article" @default.