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- W2893977022 abstract "Clostridium difficile is the leading infectious cause of antibiotic-associated diarrhea and colitis. C. difficile infection (CDI) places a heavy burden on the healthcare system, with nearly half a million infections yearly and an approximate 20% recurrence risk after successful initial therapy. The high incidence has driven new research on improved prevention such as the emerging use of probiotics, intestinal microbiome manipulation during antibiotic therapies, vaccinations, and newer antibiotics that reduce the disruption of the intestinal microbiome. While the treatment of acute C. difficile is effective in most patients, it can be further optimized by adjuvant therapies that improve the initial treatment success and decrease the risk of subsequent recurrence. Finally, the high risk of recurrence has led to multiple emerging therapies that target toxin activity, recovery of the intestinal microbial community, and elimination of latent C. difficile in the intestine. In summary, CDIs illustrate the complex interaction among host physiology, microbial community, and pathogen that requires specific therapies to address each of the factors leading to primary infection and recurrence." @default.
- W2893977022 created "2018-10-05" @default.
- W2893977022 creator A5021859030 @default.
- W2893977022 creator A5049294221 @default.
- W2893977022 creator A5068789538 @default.
- W2893977022 date "2018-09-21" @default.
- W2893977022 modified "2023-10-16" @default.
- W2893977022 title "Novel therapies and preventative strategies for primary and recurrent<i>Clostridium difficile</i>infections" @default.
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