FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893985887> ?p ?o ?g. }

• W2893985887 endingPage "149" @default.
• W2893985887 startingPage "141" @default.
• W2893985887 abstract "The benefit of surgical metastasectomy (SM) for patients with metastatic renal cell carcinoma (mRCC) remains controversial because of the lack of high-level evidence on the role of SM in terms of survival benefit in the era of systemic therapy. To perform a systematic review of the literature on the role of SM in the treatment of mRCC and discuss key issues in the SM decision-making process. A systematic search of the Embase and Medline databases was carried out and a systematic review of the role of SM in mRCC was performed. A total of 56 studies were finally included in the evidence synthesis. All the studies included were retrospective and mostly noncomparative. Median overall survival (OS) ranged from 36 to 142 mo for those undergoing SM, compared to 8–27 mo for no SM. SM was associated with a lower risk of all-cause mortality compared to no SM (pooled adjusted hazard ratio 2.37, 95% confidence interval 2.03–2.87; p < 0.001). Morbidity and mortality were similar for SM and primary tumor surgery. The most important prognostic factor for OS was complete resection of metastases. Other prognostic factors included disease free-survival from nephrectomy, primary tumor features (T stage ≥3, high grade, sarcomatoid features, and pathological nodal status), the number of metastases, and performance status. Lung metastasectomy seemed to show the best survival benefit. Although no randomized clinical data are available, published studies support the role of SM in selected patients in the modern era. Complete SM allows sustained survival free of systemic treatment. Integration of SM and systemic therapy in a multimodal approach remains a valid option for some patients. Surgical resection of metastases originating from renal cell carcinoma may play a role in prolonging survival and avoiding systemic therapy when complete resection is achievable. This strategy is an option for selected patients with a limited number of metastases who still have good general health status." @default.
• W2893985887 created "2018-10-05" @default.
• W2893985887 creator A5005864006 @default.
• W2893985887 creator A5015036334 @default.
• W2893985887 creator A5017537551 @default.
• W2893985887 creator A5038974730 @default.
• W2893985887 creator A5060616205 @default.
• W2893985887 creator A5061266716 @default.
• W2893985887 creator A5082828068 @default.
• W2893985887 creator A5091833311 @default.
• W2893985887 date "2019-03-01" @default.
• W2893985887 modified "2023-10-16" @default.
• W2893985887 title "Surgical Metastasectomy in Renal Cell Carcinoma: A Systematic Review" @default.
• W2893985887 cites W1497468875 @default.
• W2893985887 cites W1577756428 @default.
• W2893985887 cites W1841821747 @default.
• W2893985887 cites W1901160194 @default.
• W2893985887 cites W1917843933 @default.
• W2893985887 cites W1965222763 @default.
• W2893985887 cites W1967054956 @default.
• W2893985887 cites W1981889581 @default.
• W2893985887 cites W1983179222 @default.
• W2893985887 cites W1987483029 @default.
• W2893985887 cites W1993948854 @default.
• W2893985887 cites W1997635370 @default.
• W2893985887 cites W2000091608 @default.
• W2893985887 cites W2000579482 @default.
• W2893985887 cites W2009107262 @default.
• W2893985887 cites W2009619282 @default.
• W2893985887 cites W2015716004 @default.
• W2893985887 cites W2018242882 @default.
• W2893985887 cites W2026134731 @default.
• W2893985887 cites W2027676253 @default.
• W2893985887 cites W2028674294 @default.
• W2893985887 cites W2030505692 @default.
• W2893985887 cites W2031237947 @default.
• W2893985887 cites W2034400843 @default.
• W2893985887 cites W2037776650 @default.
• W2893985887 cites W2038708456 @default.
• W2893985887 cites W2047283248 @default.
• W2893985887 cites W2048389149 @default.
• W2893985887 cites W2053556189 @default.
• W2893985887 cites W2056596203 @default.
• W2893985887 cites W2069224184 @default.
• W2893985887 cites W2069553852 @default.
• W2893985887 cites W2070331850 @default.
• W2893985887 cites W2072640245 @default.
• W2893985887 cites W2077111716 @default.
• W2893985887 cites W2078708687 @default.
• W2893985887 cites W2083887116 @default.
• W2893985887 cites W2087277708 @default.
• W2893985887 cites W2088581716 @default.
• W2893985887 cites W2092971360 @default.
• W2893985887 cites W2114902191 @default.
• W2893985887 cites W2120048100 @default.
• W2893985887 cites W2123793356 @default.
• W2893985887 cites W2123886696 @default.
• W2893985887 cites W2142935544 @default.
• W2893985887 cites W2144029232 @default.
• W2893985887 cites W2158497538 @default.
• W2893985887 cites W2160926061 @default.
• W2893985887 cites W2168083201 @default.
• W2893985887 cites W2191744712 @default.
• W2893985887 cites W2258991563 @default.
• W2893985887 cites W2314709079 @default.
• W2893985887 cites W2356168463 @default.
• W2893985887 cites W2411812592 @default.
• W2893985887 cites W2436351282 @default.
• W2893985887 cites W2473804725 @default.
• W2893985887 cites W2474857110 @default.
• W2893985887 cites W2503594413 @default.
• W2893985887 cites W2513137880 @default.
• W2893985887 cites W2522128722 @default.
• W2893985887 cites W2523455577 @default.
• W2893985887 cites W2598933702 @default.
• W2893985887 cites W2614480329 @default.
• W2893985887 cites W2624062543 @default.
• W2893985887 cites W2757202953 @default.
• W2893985887 cites W2761627265 @default.
• W2893985887 cites W2769471096 @default.
• W2893985887 cites W2889446552 @default.
• W2893985887 doi "https://doi.org/10.1016/j.euo.2018.08.028" @default.
• W2893985887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31017089" @default.
• W2893985887 hasPublicationYear "2019" @default.
• W2893985887 type Work @default.
• W2893985887 sameAs 2893985887 @default.
• W2893985887 citedByCount "68" @default.
• W2893985887 countsByYear W28939858872019 @default.
• W2893985887 countsByYear W28939858872020 @default.
• W2893985887 countsByYear W28939858872021 @default.
• W2893985887 countsByYear W28939858872022 @default.
• W2893985887 countsByYear W28939858872023 @default.
• W2893985887 crossrefType "journal-article" @default.
• W2893985887 hasAuthorship W2893985887A5005864006 @default.
• W2893985887 hasAuthorship W2893985887A5015036334 @default.
• W2893985887 hasAuthorship W2893985887A5017537551 @default.
• W2893985887 hasAuthorship W2893985887A5038974730 @default.
• W2893985887 hasAuthorship W2893985887A5060616205 @default.

• next