FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893990370> ?p ?o ?g. }

• W2893990370 endingPage "25" @default.
• W2893990370 startingPage "12" @default.
• W2893990370 abstract "Atrial fibrillation (AF) is prevalent in hypertension and elevated angiotensin II (Ang II); however, the mechanisms by which Ang II leads to AF are poorly understood. Here, we investigated the basis for this in mice treated with Ang II or saline for 3 weeks. Ang II treatment increased susceptibility to AF compared to saline controls in association with increases in P wave duration and atrial effective refractory period, as well as reductions in right and left atrial conduction velocity. Patch-clamp studies demonstrate that action potential (AP) duration was prolonged in right atrial myocytes from Ang II treated mice in association with a reduction in repolarizing K+ currents. In contrast, APs in left atrial myocytes from Ang II treated mice showed reductions in upstroke velocity and overshoot, as well as greater prolongations in AP duration. Ang II reduced Na+ current (INa) in the left, but not the right atrium. This reduction in INa was reversible following inhibition of protein kinase C (PKC) and PKCα expression was increased selectively in the left atrium in Ang II treated mice. The transient outward K+ current (Ito) showed larger reductions in the left atrium in association with a shift in the voltage dependence of activation. Finally, Ang II caused fibrosis throughout the atria in association with changes in collagen expression and regulators of the extracellular matrix. This study demonstrates that hypertension and elevated Ang II cause distinct patterns of electrical and structural remodeling in the right and left atria that collectively create a substrate for AF." @default.
• W2893990370 created "2018-10-05" @default.
• W2893990370 creator A5010564331 @default.
• W2893990370 creator A5024527548 @default.
• W2893990370 creator A5026472235 @default.
• W2893990370 creator A5036991580 @default.
• W2893990370 creator A5040759777 @default.
• W2893990370 creator A5052638576 @default.
• W2893990370 creator A5058323193 @default.
• W2893990370 creator A5066354737 @default.
• W2893990370 creator A5080647048 @default.
• W2893990370 date "2018-11-01" @default.
• W2893990370 modified "2023-10-15" @default.
• W2893990370 title "Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation" @default.
• W2893990370 cites W1554034981 @default.
• W2893990370 cites W1691303215 @default.
• W2893990370 cites W1755902553 @default.
• W2893990370 cites W1816549363 @default.
• W2893990370 cites W1903811733 @default.
• W2893990370 cites W1963711658 @default.
• W2893990370 cites W1967841125 @default.
• W2893990370 cites W1973576889 @default.
• W2893990370 cites W1981912996 @default.
• W2893990370 cites W1983741639 @default.
• W2893990370 cites W1994456301 @default.
• W2893990370 cites W2006189281 @default.
• W2893990370 cites W2008899120 @default.
• W2893990370 cites W2010412397 @default.
• W2893990370 cites W2025826819 @default.
• W2893990370 cites W2028163040 @default.
• W2893990370 cites W2028534230 @default.
• W2893990370 cites W2039189635 @default.
• W2893990370 cites W2050251934 @default.
• W2893990370 cites W2061511179 @default.
• W2893990370 cites W2063977326 @default.
• W2893990370 cites W2070249204 @default.
• W2893990370 cites W2077738819 @default.
• W2893990370 cites W2092882131 @default.
• W2893990370 cites W2095462919 @default.
• W2893990370 cites W2102682841 @default.
• W2893990370 cites W2112091653 @default.
• W2893990370 cites W2120939977 @default.
• W2893990370 cites W2125693777 @default.
• W2893990370 cites W2132250523 @default.
• W2893990370 cites W2132622900 @default.
• W2893990370 cites W2134820036 @default.
• W2893990370 cites W2139245232 @default.
• W2893990370 cites W2142701430 @default.
• W2893990370 cites W2143511208 @default.
• W2893990370 cites W2152501972 @default.
• W2893990370 cites W2162250890 @default.
• W2893990370 cites W2164475375 @default.
• W2893990370 cites W2165564780 @default.
• W2893990370 cites W2170813188 @default.
• W2893990370 cites W2178536160 @default.
• W2893990370 cites W2283202181 @default.
• W2893990370 cites W2284479604 @default.
• W2893990370 cites W2337855427 @default.
• W2893990370 cites W2504981678 @default.
• W2893990370 cites W2512384933 @default.
• W2893990370 cites W2522526745 @default.
• W2893990370 cites W2546425606 @default.
• W2893990370 cites W2591779593 @default.
• W2893990370 cites W2602303214 @default.
• W2893990370 cites W2604561621 @default.
• W2893990370 cites W2791234633 @default.
• W2893990370 doi "https://doi.org/10.1016/j.yjmcc.2018.09.011" @default.
• W2893990370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30273558" @default.
• W2893990370 hasPublicationYear "2018" @default.
• W2893990370 type Work @default.
• W2893990370 sameAs 2893990370 @default.
• W2893990370 citedByCount "42" @default.
• W2893990370 countsByYear W28939903702019 @default.
• W2893990370 countsByYear W28939903702020 @default.
• W2893990370 countsByYear W28939903702021 @default.
• W2893990370 countsByYear W28939903702022 @default.
• W2893990370 countsByYear W28939903702023 @default.
• W2893990370 crossrefType "journal-article" @default.
• W2893990370 hasAuthorship W2893990370A5010564331 @default.
• W2893990370 hasAuthorship W2893990370A5024527548 @default.
• W2893990370 hasAuthorship W2893990370A5026472235 @default.
• W2893990370 hasAuthorship W2893990370A5036991580 @default.
• W2893990370 hasAuthorship W2893990370A5040759777 @default.
• W2893990370 hasAuthorship W2893990370A5052638576 @default.
• W2893990370 hasAuthorship W2893990370A5058323193 @default.
• W2893990370 hasAuthorship W2893990370A5066354737 @default.
• W2893990370 hasAuthorship W2893990370A5080647048 @default.
• W2893990370 hasConcept C114021368 @default.
• W2893990370 hasConcept C126322002 @default.
• W2893990370 hasConcept C134018914 @default.
• W2893990370 hasConcept C146403970 @default.
• W2893990370 hasConcept C164705383 @default.
• W2893990370 hasConcept C170493617 @default.
• W2893990370 hasConcept C179253579 @default.
• W2893990370 hasConcept C185263204 @default.
• W2893990370 hasConcept C185592680 @default.
• W2893990370 hasConcept C189327125 @default.
• W2893990370 hasConcept C2779161974 @default.

• next