Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893991807> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2893991807 endingPage "188" @default.
- W2893991807 startingPage "182" @default.
- W2893991807 abstract "Magnesium, the second most abundant cation in cellular fluid, is critical for mineralization of hard tissues. Among the molecules involved in cellular Mg2+ homeostasis, functional impairment of Mg2+ permeable ion channel TRPM7 or Mg2+ transporter CNNM4 have been found to result in severe hypomineralization of the enamel and dentin. However, molecular expressions of TRPM7, CNNM4 and their respective homologues have not been fully investigated in adult odontoblasts.Expressions of TRPM6, TRPM7, CNNM1, CNNM2, CNNM3, CNNM4 were screened in acutely dissociated rat odontoblasts by single cell RT-PCR. Among these candidates, expression levels of TRPM7 and CNNM4 were compared along the odontoblast layer by immunohistochemical analysis. Finally, the coexpression pattern of TRPM7 and CNNM4 in subcellular regions was examined by immunocytochemical analysis.ScRT-PCR revealed high expression rate of TRPM7 and CNNM4 in odontoblasts, with CNNM4 detected almost exclusively in TRPM7-positive odontoblasts. However, CNNM2 and CNNM3 were detected in only a small population of odontoblasts, and TRPM6 and CNNM1 were not detected even in the pulp tissue. Immunohistochemical analysis revealed higher CNNM4 expression in the apical odontoblast layer than the coronal area, in contrast to the ubiquitous expression of TRPM7. Lastly, immunocytochemical analysis revealed colocalization of CNNM4 with TRPM7 in the odontoblastic process.CNNM4 and TRPM7 may serve as main Mg2+ regulators in odontoblasts, possibly with selective involvement of CNNM4 in apical dentin formation or mineralization. Colocalization of TRPM7 and CNNM4 in the odontoblastic process suggest functional coupling of these two molecules to maintain Mg2+ homeostasis." @default.
- W2893991807 created "2018-10-05" @default.
- W2893991807 creator A5005357174 @default.
- W2893991807 creator A5021732652 @default.
- W2893991807 creator A5078144938 @default.
- W2893991807 date "2018-12-01" @default.
- W2893991807 modified "2023-10-16" @default.
- W2893991807 title "Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts" @default.
- W2893991807 cites W1964640916 @default.
- W2893991807 cites W1970119870 @default.
- W2893991807 cites W1981688857 @default.
- W2893991807 cites W1991508782 @default.
- W2893991807 cites W1997568797 @default.
- W2893991807 cites W2000476894 @default.
- W2893991807 cites W2025655555 @default.
- W2893991807 cites W2034227864 @default.
- W2893991807 cites W2044517704 @default.
- W2893991807 cites W2052816497 @default.
- W2893991807 cites W2053472145 @default.
- W2893991807 cites W2055961155 @default.
- W2893991807 cites W2056053321 @default.
- W2893991807 cites W2077236158 @default.
- W2893991807 cites W2081836769 @default.
- W2893991807 cites W2082571927 @default.
- W2893991807 cites W2086835120 @default.
- W2893991807 cites W2087809543 @default.
- W2893991807 cites W2103565184 @default.
- W2893991807 cites W2137296676 @default.
- W2893991807 cites W2141673637 @default.
- W2893991807 cites W2151512622 @default.
- W2893991807 cites W2156197458 @default.
- W2893991807 cites W2165058227 @default.
- W2893991807 cites W2166073081 @default.
- W2893991807 cites W2469600880 @default.
- W2893991807 cites W2508656616 @default.
- W2893991807 cites W2524524817 @default.
- W2893991807 cites W2604310337 @default.
- W2893991807 cites W2789267651 @default.
- W2893991807 doi "https://doi.org/10.1016/j.archoralbio.2018.09.011" @default.
- W2893991807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278312" @default.
- W2893991807 hasPublicationYear "2018" @default.
- W2893991807 type Work @default.
- W2893991807 sameAs 2893991807 @default.
- W2893991807 citedByCount "10" @default.
- W2893991807 countsByYear W28939918072019 @default.
- W2893991807 countsByYear W28939918072020 @default.
- W2893991807 countsByYear W28939918072021 @default.
- W2893991807 countsByYear W28939918072022 @default.
- W2893991807 crossrefType "journal-article" @default.
- W2893991807 hasAuthorship W2893991807A5005357174 @default.
- W2893991807 hasAuthorship W2893991807A5021732652 @default.
- W2893991807 hasAuthorship W2893991807A5078144938 @default.
- W2893991807 hasConcept C142724271 @default.
- W2893991807 hasConcept C153911025 @default.
- W2893991807 hasConcept C170493617 @default.
- W2893991807 hasConcept C185592680 @default.
- W2893991807 hasConcept C2520015 @default.
- W2893991807 hasConcept C2779263046 @default.
- W2893991807 hasConcept C40209533 @default.
- W2893991807 hasConcept C50254741 @default.
- W2893991807 hasConcept C53467394 @default.
- W2893991807 hasConcept C55493867 @default.
- W2893991807 hasConcept C71924100 @default.
- W2893991807 hasConcept C86803240 @default.
- W2893991807 hasConcept C95444343 @default.
- W2893991807 hasConceptScore W2893991807C142724271 @default.
- W2893991807 hasConceptScore W2893991807C153911025 @default.
- W2893991807 hasConceptScore W2893991807C170493617 @default.
- W2893991807 hasConceptScore W2893991807C185592680 @default.
- W2893991807 hasConceptScore W2893991807C2520015 @default.
- W2893991807 hasConceptScore W2893991807C2779263046 @default.
- W2893991807 hasConceptScore W2893991807C40209533 @default.
- W2893991807 hasConceptScore W2893991807C50254741 @default.
- W2893991807 hasConceptScore W2893991807C53467394 @default.
- W2893991807 hasConceptScore W2893991807C55493867 @default.
- W2893991807 hasConceptScore W2893991807C71924100 @default.
- W2893991807 hasConceptScore W2893991807C86803240 @default.
- W2893991807 hasConceptScore W2893991807C95444343 @default.
- W2893991807 hasLocation W28939918071 @default.
- W2893991807 hasLocation W28939918072 @default.
- W2893991807 hasOpenAccess W2893991807 @default.
- W2893991807 hasPrimaryLocation W28939918071 @default.
- W2893991807 hasRelatedWork W1942059654 @default.
- W2893991807 hasRelatedWork W1994974842 @default.
- W2893991807 hasRelatedWork W2041707076 @default.
- W2893991807 hasRelatedWork W2087394924 @default.
- W2893991807 hasRelatedWork W2088435008 @default.
- W2893991807 hasRelatedWork W2104084780 @default.
- W2893991807 hasRelatedWork W2384498919 @default.
- W2893991807 hasRelatedWork W2394877683 @default.
- W2893991807 hasRelatedWork W2413903194 @default.
- W2893991807 hasRelatedWork W4253813032 @default.
- W2893991807 hasVolume "96" @default.
- W2893991807 isParatext "false" @default.
- W2893991807 isRetracted "false" @default.
- W2893991807 magId "2893991807" @default.
- W2893991807 workType "article" @default.