FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893994703> ?p ?o ?g. }

• W2893994703 endingPage "10254" @default.
• W2893994703 startingPage "10250" @default.
• W2893994703 abstract "Abstract A series of diethylene glycol tethered bis‐istain derivatives 4 a‐o were designed, synthesized and screened for their biological activities in this paper. Eight bis‐isatin derivatives displayed broad‐spectrum activities against all tested drug‐sensitive and drug‐resistant cancer cells with IC 50 in a range of 8.32 to 49.73 μ M. The most active derivative 4 d was >2.5 folds more potent than etoposide against Hela, HCT‐116, A549 and drug‐resistant MCF‐7/DOX (Doxorubicin‐resistant MCF‐7) cells and was comparable to etoposide against DU145, SKOV3 and MCF‐7. Tubulin inhibitory results suggested that this kind of bis‐istain derivatives could exert their anti‐cancer activities through tubulin inhibition. The eight bis‐isatin derivatives with high anti‐tumor activity were selected for further screen to investigate their anti‐mycobacterial and anti‐HIV activities, but the majority of them only exhibited weak to moderate activities." @default.
• W2893994703 created "2018-10-05" @default.
• W2893994703 creator A5000432967 @default.
• W2893994703 creator A5008864873 @default.
• W2893994703 creator A5030477809 @default.
• W2893994703 creator A5073042371 @default.
• W2893994703 creator A5082016315 @default.
• W2893994703 creator A5090938181 @default.
• W2893994703 date "2018-09-27" @default.
• W2893994703 modified "2023-10-10" @default.
• W2893994703 title "Synthesis and In Vitro Anti-Tumor, Anti-Mycobacterial and Anti-HIV Activities of Diethylene-Glycol-Tethered Bis-Isatin Derivatives" @default.
• W2893994703 cites W1978650247 @default.
• W2893994703 cites W1991519292 @default.
• W2893994703 cites W2002281967 @default.
• W2893994703 cites W2041168948 @default.
• W2893994703 cites W2054785704 @default.
• W2893994703 cites W2084274039 @default.
• W2893994703 cites W2097303062 @default.
• W2893994703 cites W2106787323 @default.
• W2893994703 cites W2126576359 @default.
• W2893994703 cites W2151079442 @default.
• W2893994703 cites W2177048656 @default.
• W2893994703 cites W2181894935 @default.
• W2893994703 cites W2280173356 @default.
• W2893994703 cites W2300111395 @default.
• W2893994703 cites W2483503226 @default.
• W2893994703 cites W2514538223 @default.
• W2893994703 cites W2569422572 @default.
• W2893994703 cites W2604532441 @default.
• W2893994703 cites W2607447439 @default.
• W2893994703 cites W2618192533 @default.
• W2893994703 cites W2620854630 @default.
• W2893994703 cites W2649942267 @default.
• W2893994703 cites W2736621155 @default.
• W2893994703 cites W2758618425 @default.
• W2893994703 cites W2767948484 @default.
• W2893994703 cites W2788154234 @default.
• W2893994703 cites W2796375271 @default.
• W2893994703 cites W2799948047 @default.
• W2893994703 cites W2818419433 @default.
• W2893994703 cites W4246053769 @default.
• W2893994703 cites W4250828393 @default.
• W2893994703 doi "https://doi.org/10.1002/slct.201802185" @default.
• W2893994703 hasPublicationYear "2018" @default.
• W2893994703 type Work @default.
• W2893994703 sameAs 2893994703 @default.
• W2893994703 citedByCount "30" @default.
• W2893994703 countsByYear W28939947032019 @default.
• W2893994703 countsByYear W28939947032020 @default.
• W2893994703 countsByYear W28939947032021 @default.
• W2893994703 countsByYear W28939947032022 @default.
• W2893994703 countsByYear W28939947032023 @default.
• W2893994703 crossrefType "journal-article" @default.
• W2893994703 hasAuthorship W2893994703A5000432967 @default.
• W2893994703 hasAuthorship W2893994703A5008864873 @default.
• W2893994703 hasAuthorship W2893994703A5030477809 @default.
• W2893994703 hasAuthorship W2893994703A5073042371 @default.
• W2893994703 hasAuthorship W2893994703A5082016315 @default.
• W2893994703 hasAuthorship W2893994703A5090938181 @default.
• W2893994703 hasConcept C121608353 @default.
• W2893994703 hasConcept C126322002 @default.
• W2893994703 hasConcept C141071460 @default.
• W2893994703 hasConcept C178790620 @default.
• W2893994703 hasConcept C185592680 @default.
• W2893994703 hasConcept C202751555 @default.
• W2893994703 hasConcept C21951064 @default.
• W2893994703 hasConcept C2776438761 @default.
• W2893994703 hasConcept C2776694085 @default.
• W2893994703 hasConcept C2777256644 @default.
• W2893994703 hasConcept C2777366897 @default.
• W2893994703 hasConcept C2777516009 @default.
• W2893994703 hasConcept C2778119113 @default.
• W2893994703 hasConcept C2779136216 @default.
• W2893994703 hasConcept C2779723316 @default.
• W2893994703 hasConcept C55493867 @default.
• W2893994703 hasConcept C71240020 @default.
• W2893994703 hasConcept C71924100 @default.
• W2893994703 hasConcept C96232424 @default.
• W2893994703 hasConcept C98274493 @default.
• W2893994703 hasConceptScore W2893994703C121608353 @default.
• W2893994703 hasConceptScore W2893994703C126322002 @default.
• W2893994703 hasConceptScore W2893994703C141071460 @default.
• W2893994703 hasConceptScore W2893994703C178790620 @default.
• W2893994703 hasConceptScore W2893994703C185592680 @default.
• W2893994703 hasConceptScore W2893994703C202751555 @default.
• W2893994703 hasConceptScore W2893994703C21951064 @default.
• W2893994703 hasConceptScore W2893994703C2776438761 @default.
• W2893994703 hasConceptScore W2893994703C2776694085 @default.
• W2893994703 hasConceptScore W2893994703C2777256644 @default.
• W2893994703 hasConceptScore W2893994703C2777366897 @default.
• W2893994703 hasConceptScore W2893994703C2777516009 @default.
• W2893994703 hasConceptScore W2893994703C2778119113 @default.
• W2893994703 hasConceptScore W2893994703C2779136216 @default.
• W2893994703 hasConceptScore W2893994703C2779723316 @default.
• W2893994703 hasConceptScore W2893994703C55493867 @default.
• W2893994703 hasConceptScore W2893994703C71240020 @default.
• W2893994703 hasConceptScore W2893994703C71924100 @default.
• W2893994703 hasConceptScore W2893994703C96232424 @default.

• next