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- W2893997134 abstract "In the last decades significant progress has been carried out leading to significant advances in the development of engineered tissues, thanks to taking into account three fundamental components: the cells to address tissue formation, a scaffold useful as substrate for tissue growth and development, growth factors and/or biomechanical stimuli to address the differentiation of cells within the scaffolds. In particular, mechanical stimuli are known to play a key role in bone tissue formation and mineralization.Mechanical actuators, namely bioreactor systems, can be used to enhance in vitro culture steps in the overall cell-based tissue engineering strategy of expanding in vitro a stem cell source to be cultured and differentiated on a three-dimensional scaffold, aiming at implanting this scaffold in vivo.The purpose of this study is thus to design a stand-alone perfusion/compression bioreactor system. The developed prototypal system allows to apply physical stimuli mimicking native loading regimens. The results obtained in human bone marrow stem cells (hBMSCs) onboard of a 3D graphene/chitosan scaffold indicate that their exposure to a controlled dynamic environment is suitable to address bone tissue commitment." @default.
- W2893997134 created "2018-10-05" @default.
- W2893997134 creator A5016807135 @default.
- W2893997134 date "2018-05-04" @default.
- W2893997134 modified "2023-09-27" @default.
- W2893997134 title "Development of an innovative bioreactor system for human bone tissue engineering" @default.
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- W2893997134 doi "https://doi.org/10.6092/unibo/amsdottorato/8676" @default.
- W2893997134 hasPublicationYear "2018" @default.
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