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• W2894021672 abstract "The Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%-70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of the neural correlates associated with food-processing and cognitive performance in patients with morbid obesity before and after RYGB relative to lean controls.This study is a pre-post case-control experiment. Using functional MRI, the neural responses to food stimuli and a working memory task will be compared between 25 patients with obesity, pre and post RYGB, and a matched, lean control group. Resting state fMRI will be measured to investigate functional brain connectivity. Baseline measurements for both groups will take place 4 weeks prior to RYGB and 12 months after RYGB. The effects of RYGB on peptide tyrosine tyrosine and glucagon-like polypeptide-1 will also be determined.The project has received ethical approval by the local medical ethics committee of the Carl-von-Ossietzky University of Oldenburg, Germany (registration: 2017-073). Results will be published in a peer-reviewed journal as original research and on international conferences.DRKS00012495; Pre-results." @default.
• W2894021672 created "2018-10-05" @default.
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• W2894021672 date "2018-09-01" @default.
• W2894021672 modified "2023-10-17" @default.
• W2894021672 title "Impact of bariatric surgery on neural food processing and cognition: an fMRI study" @default.
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• W2894021672 doi "https://doi.org/10.1136/bmjopen-2018-022375" @default.
• W2894021672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6169753" @default.
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