Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894022906> ?p ?o ?g. }
- W2894022906 endingPage "485" @default.
- W2894022906 startingPage "476" @default.
- W2894022906 abstract "To develop a pre‐emptive genetic test that comprises multiple predisposing alleles for the prevention of phenytoin‐related severe cutaneous adverse reactions ( SCARs ), three sets of patients with phenytoin‐ SCAR and drug‐tolerant controls from Taiwan, Thailand, and Japan, were enrolled for this study. In addition to cytochrome P450 ( CYP ) 2C9*3 , we found that HLA ‐B*13:01 , HLA ‐B*15:02 , and HLA ‐B*51:01 were significantly associated with phenytoin hypersensitivity with distinct phenotypic specificities. Strikingly, we showed an increase in predictive sensitivity of concurrently testing CYP 2C9*3 / HLA ‐B*13:01 / HLA ‐B*15:02 / HLA ‐B*51:01 from 30.5–71.9% for selecting the individuals with the risk of developing phenytoin‐ SCAR in Taiwanese cohorts, accompanied by a specificity of 77.7% (combined sensitivity, 64.7%; specificity, 71.9% for three Asian populations). Meta‐analysis of the four combined risk alleles showed significant associations with phenytoin‐ SCAR in three Asian populations. In conclusion, combining the assessment of risk alleles of HLA and CYP 2C9 potentiated the usefulness of predictive genetic tests to prevent phenytoin hypersensitivity in Asians." @default.
- W2894022906 created "2018-10-05" @default.
- W2894022906 creator A5005508460 @default.
- W2894022906 creator A5011719696 @default.
- W2894022906 creator A5018047872 @default.
- W2894022906 creator A5018507990 @default.
- W2894022906 creator A5020320910 @default.
- W2894022906 creator A5028685212 @default.
- W2894022906 creator A5029687156 @default.
- W2894022906 creator A5031155500 @default.
- W2894022906 creator A5035667956 @default.
- W2894022906 creator A5039567335 @default.
- W2894022906 creator A5043638381 @default.
- W2894022906 creator A5048561277 @default.
- W2894022906 creator A5053281846 @default.
- W2894022906 creator A5055833929 @default.
- W2894022906 creator A5057475035 @default.
- W2894022906 creator A5067205844 @default.
- W2894022906 creator A5068441645 @default.
- W2894022906 creator A5069476520 @default.
- W2894022906 creator A5076566996 @default.
- W2894022906 creator A5078738149 @default.
- W2894022906 creator A5079921975 @default.
- W2894022906 creator A5085741536 @default.
- W2894022906 date "2018-09-30" @default.
- W2894022906 modified "2023-10-17" @default.
- W2894022906 title "<scp>HLA</scp> Alleles and <i><scp>CYP</scp>2C9*3</i> as Predictors of Phenytoin Hypersensitivity in East Asians" @default.
- W2894022906 cites W1484447267 @default.
- W2894022906 cites W1964959751 @default.
- W2894022906 cites W1978165371 @default.
- W2894022906 cites W2006926459 @default.
- W2894022906 cites W2007176607 @default.
- W2894022906 cites W2009107589 @default.
- W2894022906 cites W2045391651 @default.
- W2894022906 cites W2049902892 @default.
- W2894022906 cites W2052372045 @default.
- W2894022906 cites W2061631865 @default.
- W2894022906 cites W2066724445 @default.
- W2894022906 cites W2067978628 @default.
- W2894022906 cites W2073057919 @default.
- W2894022906 cites W2081167060 @default.
- W2894022906 cites W2083508836 @default.
- W2894022906 cites W2087191895 @default.
- W2894022906 cites W2095428415 @default.
- W2894022906 cites W2105735228 @default.
- W2894022906 cites W2108686931 @default.
- W2894022906 cites W2113610481 @default.
- W2894022906 cites W2114365596 @default.
- W2894022906 cites W2115832251 @default.
- W2894022906 cites W2134537227 @default.
- W2894022906 cites W2154756326 @default.
- W2894022906 cites W2163917891 @default.
- W2894022906 cites W2168850597 @default.
- W2894022906 cites W2292680314 @default.
- W2894022906 cites W2315431881 @default.
- W2894022906 cites W2317624504 @default.
- W2894022906 cites W2405053777 @default.
- W2894022906 cites W2536933937 @default.
- W2894022906 cites W2550981837 @default.
- W2894022906 cites W2554958497 @default.
- W2894022906 cites W2604762471 @default.
- W2894022906 cites W2610282076 @default.
- W2894022906 cites W2614087518 @default.
- W2894022906 cites W2779204423 @default.
- W2894022906 doi "https://doi.org/10.1002/cpt.1190" @default.
- W2894022906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30270535" @default.
- W2894022906 hasPublicationYear "2018" @default.
- W2894022906 type Work @default.
- W2894022906 sameAs 2894022906 @default.
- W2894022906 citedByCount "47" @default.
- W2894022906 countsByYear W28940229062019 @default.
- W2894022906 countsByYear W28940229062020 @default.
- W2894022906 countsByYear W28940229062021 @default.
- W2894022906 countsByYear W28940229062022 @default.
- W2894022906 countsByYear W28940229062023 @default.
- W2894022906 crossrefType "journal-article" @default.
- W2894022906 hasAuthorship W2894022906A5005508460 @default.
- W2894022906 hasAuthorship W2894022906A5011719696 @default.
- W2894022906 hasAuthorship W2894022906A5018047872 @default.
- W2894022906 hasAuthorship W2894022906A5018507990 @default.
- W2894022906 hasAuthorship W2894022906A5020320910 @default.
- W2894022906 hasAuthorship W2894022906A5028685212 @default.
- W2894022906 hasAuthorship W2894022906A5029687156 @default.
- W2894022906 hasAuthorship W2894022906A5031155500 @default.
- W2894022906 hasAuthorship W2894022906A5035667956 @default.
- W2894022906 hasAuthorship W2894022906A5039567335 @default.
- W2894022906 hasAuthorship W2894022906A5043638381 @default.
- W2894022906 hasAuthorship W2894022906A5048561277 @default.
- W2894022906 hasAuthorship W2894022906A5053281846 @default.
- W2894022906 hasAuthorship W2894022906A5055833929 @default.
- W2894022906 hasAuthorship W2894022906A5057475035 @default.
- W2894022906 hasAuthorship W2894022906A5067205844 @default.
- W2894022906 hasAuthorship W2894022906A5068441645 @default.
- W2894022906 hasAuthorship W2894022906A5069476520 @default.
- W2894022906 hasAuthorship W2894022906A5076566996 @default.
- W2894022906 hasAuthorship W2894022906A5078738149 @default.
- W2894022906 hasAuthorship W2894022906A5079921975 @default.
- W2894022906 hasAuthorship W2894022906A5085741536 @default.