FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894025443> ?p ?o ?g. }

• W2894025443 abstract "The Amyloid β peptide (Aβ) is a main component of senile plaques in Alzheimer's disease. Currently, NADPH oxidase (NOX) and mitochondria are considered as primary sources of ROS induced by Aβ. However, the contribution of NOX and mitochondria to Aβ-induced ROS generation has not been well defined. To delineate the relative involvement of NOX and mitochondria in Aβ-induced ROS generation and neuronal death in mouse cortical cultures, we examined the effect of NOX inhibitors, apocynin and AEBSF, and the mitochondria-targeted antioxidants (MTAs), mitotempol and mitoquinone, on Aβ-induced ROS generation and neuronal deaths. Cell death was assessed by measuring lactate dehydrogenase efflux in bathing media at 24 and 48 hrs after exposure to Aβ1-42. Aβ1-42 induced dose- and time-dependent neuronal deaths in cortical cultures. Treatment with 20 µM Aβ1-42 markedly and continuously increased not only the DHE fluorescence (intracellular ROS signal), but also the DHR123 fluorescence (mitochondrial ROS signal) up to 8 hrs. Treatment with apocynin or AEBSF selectively suppressed the increase in DHE fluorescence, while treatment with mitotempol selectively suppressed the increase in DHR123 fluorescence. Each treatment with apocynin, AEBSF, mitotempol or mitoquinone significantly attenuated the Aβ1-42-induced neuronal deaths. However, any combined treatment with apocynin/AEBSF and mitotempol/mitoquinone failed to show additive effects. These findings indicate that 20 µM Aβ1-42 induces oxidative neuronal death via inducing mitochondrial ROS as well as NOX activation in mixed cortical cultures, but combined suppression of intracellular and mitochondrial ROS generation fail to show any additive neuroprotective effects against Aβ neurotoxicity." @default.
• W2894025443 created "2018-10-05" @default.
• W2894025443 creator A5068657170 @default.
• W2894025443 creator A5085047820 @default.
• W2894025443 date "2018-01-01" @default.
• W2894025443 modified "2023-10-16" @default.
• W2894025443 title "Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid β1-42-Induced Neuronal Deaths in Mouse Mixed Cortical Cultures" @default.
• W2894025443 cites W17013332 @default.
• W2894025443 cites W1971167579 @default.
• W2894025443 cites W1976625832 @default.
• W2894025443 cites W1986200442 @default.
• W2894025443 cites W1989972829 @default.
• W2894025443 cites W1996562399 @default.
• W2894025443 cites W1996885665 @default.
• W2894025443 cites W1997684038 @default.
• W2894025443 cites W1999543531 @default.
• W2894025443 cites W2019871046 @default.
• W2894025443 cites W2032423144 @default.
• W2894025443 cites W2042046011 @default.
• W2894025443 cites W2048718653 @default.
• W2894025443 cites W2052052271 @default.
• W2894025443 cites W2101347882 @default.
• W2894025443 cites W2116489922 @default.
• W2894025443 cites W2119780153 @default.
• W2894025443 cites W2122245970 @default.
• W2894025443 cites W2135304046 @default.
• W2894025443 cites W2148937128 @default.
• W2894025443 cites W2275617674 @default.
• W2894025443 cites W2567271475 @default.
• W2894025443 cites W2745246014 @default.
• W2894025443 cites W2746658569 @default.
• W2894025443 cites W2762082693 @default.
• W2894025443 cites W3142067702 @default.
• W2894025443 cites W4247759744 @default.
• W2894025443 doi "https://doi.org/10.4068/cmj.2018.54.3.159" @default.
• W2894025443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6165920" @default.
• W2894025443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30288371" @default.
• W2894025443 hasPublicationYear "2018" @default.
• W2894025443 type Work @default.
• W2894025443 sameAs 2894025443 @default.
• W2894025443 citedByCount "6" @default.
• W2894025443 countsByYear W28940254432020 @default.
• W2894025443 countsByYear W28940254432021 @default.
• W2894025443 countsByYear W28940254432022 @default.
• W2894025443 crossrefType "journal-article" @default.
• W2894025443 hasAuthorship W2894025443A5068657170 @default.
• W2894025443 hasAuthorship W2894025443A5085047820 @default.
• W2894025443 hasBestOaLocation W28940254431 @default.
• W2894025443 hasConcept C126322002 @default.
• W2894025443 hasConcept C153911025 @default.
• W2894025443 hasConcept C190283241 @default.
• W2894025443 hasConcept C2777209548 @default.
• W2894025443 hasConcept C2778175917 @default.
• W2894025443 hasConcept C2779134260 @default.
• W2894025443 hasConcept C2779719074 @default.
• W2894025443 hasConcept C28859421 @default.
• W2894025443 hasConcept C31573885 @default.
• W2894025443 hasConcept C48349386 @default.
• W2894025443 hasConcept C502032728 @default.
• W2894025443 hasConcept C55493867 @default.
• W2894025443 hasConcept C68026918 @default.
• W2894025443 hasConcept C71924100 @default.
• W2894025443 hasConcept C79879829 @default.
• W2894025443 hasConcept C86803240 @default.
• W2894025443 hasConcept C98274493 @default.
• W2894025443 hasConceptScore W2894025443C126322002 @default.
• W2894025443 hasConceptScore W2894025443C153911025 @default.
• W2894025443 hasConceptScore W2894025443C190283241 @default.
• W2894025443 hasConceptScore W2894025443C2777209548 @default.
• W2894025443 hasConceptScore W2894025443C2778175917 @default.
• W2894025443 hasConceptScore W2894025443C2779134260 @default.
• W2894025443 hasConceptScore W2894025443C2779719074 @default.
• W2894025443 hasConceptScore W2894025443C28859421 @default.
• W2894025443 hasConceptScore W2894025443C31573885 @default.
• W2894025443 hasConceptScore W2894025443C48349386 @default.
• W2894025443 hasConceptScore W2894025443C502032728 @default.
• W2894025443 hasConceptScore W2894025443C55493867 @default.
• W2894025443 hasConceptScore W2894025443C68026918 @default.
• W2894025443 hasConceptScore W2894025443C71924100 @default.
• W2894025443 hasConceptScore W2894025443C79879829 @default.
• W2894025443 hasConceptScore W2894025443C86803240 @default.
• W2894025443 hasConceptScore W2894025443C98274493 @default.
• W2894025443 hasLocation W28940254431 @default.
• W2894025443 hasLocation W28940254432 @default.
• W2894025443 hasLocation W28940254433 @default.
• W2894025443 hasLocation W28940254434 @default.
• W2894025443 hasOpenAccess W2894025443 @default.
• W2894025443 hasPrimaryLocation W28940254431 @default.
• W2894025443 hasRelatedWork W1980959883 @default.
• W2894025443 hasRelatedWork W2011124873 @default.
• W2894025443 hasRelatedWork W2029195231 @default.
• W2894025443 hasRelatedWork W2058338257 @default.
• W2894025443 hasRelatedWork W2116774706 @default.
• W2894025443 hasRelatedWork W2587975254 @default.
• W2894025443 hasRelatedWork W2894025443 @default.
• W2894025443 hasRelatedWork W2912202666 @default.
• W2894025443 hasRelatedWork W3176494547 @default.
• W2894025443 hasRelatedWork W51587896 @default.
• W2894025443 isParatext "false" @default.
• W2894025443 isRetracted "false" @default.

• next