FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894025701> ?p ?o ?g. }

• W2894025701 endingPage "6751" @default.
• W2894025701 startingPage "6744" @default.
• W2894025701 abstract "There is a high incidence of adenovirus (AdV) infection in humans due to the presence of more than 60 types of human adenoviruses (HAdVs). The majority of individuals are exposed to one or more HAdV types early in their lives, leading to the development of AdV type-specific neutralizing antibodies. Similarly, immunization or gene therapy with AdV vectors leads to immune responses to the AdV vector. This 'vector immunity' is a concern for AdV vector-based applications for vaccines or gene therapy, especially when the repeated administration of a vector is required. The objective of this investigation was to establish whether AdV neutralizing antibody titers decline sufficiently in a year to permit annual vaccination with the same AdV vector. Naïve or human adenoviral vector group C, type 5 (HAdV-C5)-primed mice were mock-inoculated (with PBS) or inoculated i.m. with 108 PFU of either HAd-GFP [HAdV-C5 vector expressing the green fluorescent protein (GFP)] to mimic the conditions for the first inoculation with an AdV vector-based vaccine. At 1, 3, 6, and 10 months post-HAd-GFP inoculation, naïve- or HAdV-primed animals were vaccinated i.m. with 108 PFU of HAd-H5HA [HAdV-C5 vector expressing hemagglutinin (HA) of H5N1 influenza virus]. There was a significant continual decrease in vector immunity titers with time, thereby leading to significant continual increases in the levels of HA-specific humoral and cell-mediated immune responses. In addition, significant improvement in protection efficacy against challenge with an antigenically heterologous H5N1 virus was observed in HAdV-primed animals at 6 months and onwards. These results indicate that the annual immunization with the same AdV vector may be effective due to a significant decline in vector immunity." @default.
• W2894025701 created "2018-10-05" @default.
• W2894025701 creator A5010891569 @default.
• W2894025701 creator A5018941916 @default.
• W2894025701 creator A5024798962 @default.
• W2894025701 creator A5033197110 @default.
• W2894025701 creator A5040833799 @default.
• W2894025701 creator A5044575988 @default.
• W2894025701 creator A5060208706 @default.
• W2894025701 creator A5066705529 @default.
• W2894025701 creator A5087827482 @default.
• W2894025701 date "2018-10-01" @default.
• W2894025701 modified "2023-09-27" @default.
• W2894025701 title "Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy" @default.
• W2894025701 cites W1654741967 @default.
• W2894025701 cites W1895663386 @default.
• W2894025701 cites W1967869186 @default.
• W2894025701 cites W1971656628 @default.
• W2894025701 cites W1974676361 @default.
• W2894025701 cites W1979745197 @default.
• W2894025701 cites W1982712041 @default.
• W2894025701 cites W1993103348 @default.
• W2894025701 cites W2006484658 @default.
• W2894025701 cites W2008259383 @default.
• W2894025701 cites W2022294540 @default.
• W2894025701 cites W2038723152 @default.
• W2894025701 cites W2044296969 @default.
• W2894025701 cites W2048340513 @default.
• W2894025701 cites W2056657026 @default.
• W2894025701 cites W2058349255 @default.
• W2894025701 cites W2064487174 @default.
• W2894025701 cites W2071387580 @default.
• W2894025701 cites W2077698364 @default.
• W2894025701 cites W2083033926 @default.
• W2894025701 cites W2083824233 @default.
• W2894025701 cites W2087315549 @default.
• W2894025701 cites W2087677579 @default.
• W2894025701 cites W2101954404 @default.
• W2894025701 cites W2105809563 @default.
• W2894025701 cites W2106127585 @default.
• W2894025701 cites W2106280992 @default.
• W2894025701 cites W2107598742 @default.
• W2894025701 cites W2138543359 @default.
• W2894025701 cites W2143749967 @default.
• W2894025701 cites W2149093119 @default.
• W2894025701 cites W2163053975 @default.
• W2894025701 cites W2164151960 @default.
• W2894025701 cites W2338153609 @default.
• W2894025701 cites W2410005479 @default.
• W2894025701 cites W2773464652 @default.
• W2894025701 cites W2809630911 @default.
• W2894025701 cites W2825912598 @default.
• W2894025701 cites W2826397905 @default.
• W2894025701 doi "https://doi.org/10.1016/j.vaccine.2018.09.031" @default.
• W2894025701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200586" @default.
• W2894025701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266488" @default.
• W2894025701 hasPublicationYear "2018" @default.
• W2894025701 type Work @default.
• W2894025701 sameAs 2894025701 @default.
• W2894025701 citedByCount "12" @default.
• W2894025701 countsByYear W28940257012019 @default.
• W2894025701 countsByYear W28940257012020 @default.
• W2894025701 countsByYear W28940257012021 @default.
• W2894025701 countsByYear W28940257012022 @default.
• W2894025701 countsByYear W28940257012023 @default.
• W2894025701 crossrefType "journal-article" @default.
• W2894025701 hasAuthorship W2894025701A5010891569 @default.
• W2894025701 hasAuthorship W2894025701A5018941916 @default.
• W2894025701 hasAuthorship W2894025701A5024798962 @default.
• W2894025701 hasAuthorship W2894025701A5033197110 @default.
• W2894025701 hasAuthorship W2894025701A5040833799 @default.
• W2894025701 hasAuthorship W2894025701A5044575988 @default.
• W2894025701 hasAuthorship W2894025701A5060208706 @default.
• W2894025701 hasAuthorship W2894025701A5066705529 @default.
• W2894025701 hasAuthorship W2894025701A5087827482 @default.
• W2894025701 hasBestOaLocation W28940257012 @default.
• W2894025701 hasConcept C104317684 @default.
• W2894025701 hasConcept C111599444 @default.
• W2894025701 hasConcept C159047783 @default.
• W2894025701 hasConcept C159654299 @default.
• W2894025701 hasConcept C203014093 @default.
• W2894025701 hasConcept C22070199 @default.
• W2894025701 hasConcept C2522874641 @default.
• W2894025701 hasConcept C2776548049 @default.
• W2894025701 hasConcept C2776954459 @default.
• W2894025701 hasConcept C2778692840 @default.
• W2894025701 hasConcept C2779261636 @default.
• W2894025701 hasConcept C2779341262 @default.
• W2894025701 hasConcept C2780115692 @default.
• W2894025701 hasConcept C2780801004 @default.
• W2894025701 hasConcept C32470452 @default.
• W2894025701 hasConcept C32611913 @default.
• W2894025701 hasConcept C40767141 @default.
• W2894025701 hasConcept C55493867 @default.
• W2894025701 hasConcept C86803240 @default.
• W2894025701 hasConcept C8891405 @default.
• W2894025701 hasConcept C92087593 @default.
• W2894025701 hasConceptScore W2894025701C104317684 @default.

• next