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- W2894027924 abstract "Abstract Plasmodium parasites exerted a strong selective pressure on primate genomes and mutations in genes encoding erythrocyte cytoskeleton proteins (ECP) determine protective effects against Plasmodium infection/pathogenesis. We thus hypothesized that ECP-encoding genes have evolved in response to Plasmodium -driven selection. We analyzed the evolutionary history of 15 ECP-encoding genes in primates, as well as of their Plasmodium -encoded ligands (KAHRP, MESA and EMP3). Results indicated that EPB42 , SLC4A1 , and SPTA1 evolved under pervasive positive selection and that episodes of positive selection tended to occur more frequently in primate species that host a larger number of Plasmodium parasites. Conversely, several genes, including ANK1 and SPTB , displayed extensive signatures of purifying selection in primate phylogenies, Homininae lineages, and human populations, suggesting strong functional constraints. Analysis of Plasmodium genes indicated adaptive evolution in MESA and KAHRP ; in the latter, different positively selected sites were located in the spectrin-binding domains. Because most of the positively selected sites in alpha-spectrin localized to the domains involved in the interaction with KAHRP, we suggest that the two proteins are engaged in an arms-race scenario. This observation is relevant because KAHRP is essential for the formation of “knobs”, which represent a major virulence determinant for P . falciparum ." @default.
- W2894027924 created "2018-10-05" @default.
- W2894027924 creator A5033073054 @default.
- W2894027924 creator A5035231715 @default.
- W2894027924 creator A5053291807 @default.
- W2894027924 creator A5069534962 @default.
- W2894027924 date "2018-10-02" @default.
- W2894027924 modified "2023-10-14" @default.
- W2894027924 title "Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins" @default.
- W2894027924 cites W113427216 @default.
- W2894027924 cites W1485626074 @default.
- W2894027924 cites W1850334472 @default.
- W2894027924 cites W1880845650 @default.
- W2894027924 cites W1895035712 @default.
- W2894027924 cites W1984080130 @default.
- W2894027924 cites W1992644072 @default.
- W2894027924 cites W1995447786 @default.
- W2894027924 cites W2000706958 @default.
- W2894027924 cites W2008065249 @default.
- W2894027924 cites W2015222800 @default.
- W2894027924 cites W2016667536 @default.
- W2894027924 cites W2023520799 @default.
- W2894027924 cites W2025293217 @default.
- W2894027924 cites W2031009230 @default.
- W2894027924 cites W2038581366 @default.
- W2894027924 cites W2039393024 @default.
- W2894027924 cites W2050276404 @default.
- W2894027924 cites W2057538311 @default.
- W2894027924 cites W2060586276 @default.
- W2894027924 cites W2064306519 @default.
- W2894027924 cites W2066980371 @default.
- W2894027924 cites W2068972301 @default.
- W2894027924 cites W2074830661 @default.
- W2894027924 cites W2075700927 @default.
- W2894027924 cites W2076617993 @default.
- W2894027924 cites W2081711923 @default.
- W2894027924 cites W2085793846 @default.
- W2894027924 cites W2086860029 @default.
- W2894027924 cites W2090459727 @default.
- W2894027924 cites W2097600571 @default.
- W2894027924 cites W2097730814 @default.
- W2894027924 cites W2101516826 @default.
- W2894027924 cites W2108048244 @default.
- W2894027924 cites W2108512869 @default.
- W2894027924 cites W2110335151 @default.
- W2894027924 cites W2114794895 @default.
- W2894027924 cites W2114828923 @default.
- W2894027924 cites W2116765819 @default.
- W2894027924 cites W2117312427 @default.
- W2894027924 cites W2118982822 @default.
- W2894027924 cites W2127676225 @default.
- W2894027924 cites W2128252987 @default.
- W2894027924 cites W2129775611 @default.
- W2894027924 cites W2131203559 @default.
- W2894027924 cites W2136847298 @default.
- W2894027924 cites W2138178197 @default.
- W2894027924 cites W2140028978 @default.
- W2894027924 cites W2142227008 @default.
- W2894027924 cites W2142338033 @default.
- W2894027924 cites W2149886005 @default.
- W2894027924 cites W2152076818 @default.
- W2894027924 cites W2154250664 @default.
- W2894027924 cites W2156081959 @default.
- W2894027924 cites W2156387134 @default.
- W2894027924 cites W2156636923 @default.
- W2894027924 cites W2160378127 @default.
- W2894027924 cites W2162132910 @default.
- W2894027924 cites W2162400913 @default.
- W2894027924 cites W2162453955 @default.
- W2894027924 cites W2168935866 @default.
- W2894027924 cites W2171372458 @default.
- W2894027924 cites W2171777347 @default.
- W2894027924 cites W2173294776 @default.
- W2894027924 cites W2427553192 @default.
- W2894027924 cites W2473201955 @default.
- W2894027924 cites W2508197929 @default.
- W2894027924 cites W2508378919 @default.
- W2894027924 cites W2508607720 @default.
- W2894027924 cites W2536108399 @default.
- W2894027924 cites W2587067599 @default.
- W2894027924 cites W2610114792 @default.
- W2894027924 cites W2626179267 @default.
- W2894027924 cites W2744951116 @default.
- W2894027924 cites W2749945688 @default.
- W2894027924 cites W2754294335 @default.
- W2894027924 cites W2758232878 @default.
- W2894027924 cites W2765886061 @default.
- W2894027924 cites W2771041623 @default.
- W2894027924 cites W2774414344 @default.
- W2894027924 cites W2785665883 @default.
- W2894027924 cites W2950095960 @default.
- W2894027924 cites W2953306613 @default.
- W2894027924 cites W4210702584 @default.
- W2894027924 cites W4211136995 @default.
- W2894027924 doi "https://doi.org/10.1038/s41598-018-33049-y" @default.
- W2894027924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6168477" @default.
- W2894027924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279439" @default.
- W2894027924 hasPublicationYear "2018" @default.
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