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• W2894031862 abstract "Subclinical hyperthyroidism is a common clinical entity, defined by serum TSH below the reference range, with normal FT4 and FT3 levels in an asymptomatic patient. Whether or not subclinical hyperthyroidism should be treated remains a matter of debate. Cross-sectional and longitudinal population-based studies demonstrate association of subclinical hyperthyroidism with risk of atrial fibrillation and osteoporosis, and with cardiovascular and all-cause mortality. However, there are no randomized clinical trials addressing whether long-term health outcomes are improved by treating subclinical hyperthyroidism; in the absence of evidence one way or the other, it seems appropriate to use decision trees taking account of TSH concentration and presence of risk factors (age > 65 years or post-menopause, osteoporosis and cardiac disease). L’hyperthyroïdie infra-clinique est une entité clinique fréquente. Elle se définit biologiquement par la présence, chez un patient asymptomatique, d’une concentration de TSH infranormale, mais avec la persistance de concentrations normales de T4L et T3L. Que l’hyperthyroïdie infra-clinique doit être ou non traitée reste un sujet de débat. Les études transversales (cross-sectional studies) et les études longitudinales basées sur le suivi de populations ont permis de démontrer qu’une hyperthyroïdie infra-clinique est associée à une augmentation des risques de fibrillation auriculaire et d’ostéoporose, ainsi qu’à une augmentation de la mortalité cardiovasculaire et de la mortalité globale. Cependant, on ne dispose pas d’essais cliniques randomisés permettant de savoir si le traitement de l’hyperthyroïdie infra-clinique améliore de manière durable ces différents paramètres. Par conséquent, en l’absence de preuves en faveur ou en défaveur du traitement de l’hyperthyroïdie infra-clinique, il semble opportun de s’inspirer des algorithmes qui prennent notamment en compte la concentration de TSH et la présence de facteurs de risque (âge > 65 ans, ostéoporose, ménopause et présence d’une pathologie cardiaque)." @default.
• W2894031862 created "2018-10-05" @default.
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• W2894031862 creator A5091552982 @default.
• W2894031862 date "2019-09-01" @default.
• W2894031862 modified "2023-10-15" @default.
• W2894031862 title "Graves’ disease, multinodular goiter and subclinical hyperthyroidism" @default.
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• W2894031862 doi "https://doi.org/10.1016/j.ando.2018.09.004" @default.
• W2894031862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31427038" @default.
• W2894031862 hasPublicationYear "2019" @default.
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