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- W2894037807 abstract "Facial nerve defects may result from trauma, tumor ablation, and iatrogenic surgical injury. Facial paralysis has functional and aesthetic effects, including an asymmetric smile, oral incompetence, and lagophthalmos with a potential for corneal injury. These physical effects can have a significant psychosocial impact and result in a decline in the patient’s quality of life (1). Cable grafting comes with slow or incomplete recovery of volitional movement. In general, 6 to 12 months are required to see recovery of facial tone followed by onset of facial movement (2). Dental pulp cells (DPCs) are emerging as a promising source of stem cells in nerve regeneration mainly due to their neural crest cell origin. As derivatives of neural crest, DPCs produce neurotrophic factors (NTF) that may have a paracrine modulatory effect on damaged axons, ultimately enhancing axon regeneration and extension. DPCs are readily available from human exfoliated teeth. Our research group is investigating DPCs’ ability to form a scaffold-free cell sheet capable of producing NTFs that can be wrapped around facial nerve defects to accelerate facial nerve healing and enhance functional recovery." @default.
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- W2894037807 date "2018-10-01" @default.
- W2894037807 modified "2023-09-26" @default.
- W2894037807 title "Scaffold-Free Dental Pulp Cell Sheets to Enhance Facial Nerve Regeneration" @default.
- W2894037807 doi "https://doi.org/10.1016/j.joms.2018.06.156" @default.
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