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- W2894046652 abstract "Abstract Signal propagation in cardiac cell networks can be modulated by heat stimulation. Here, the response of a connected HL‐1 cardiomyocyte cell network to the application of confined heat stimuli using Ca 2+ imaging is investigated. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. It is demonstrated that upon heat stimulation, the velocity of the propagating Ca 2+ wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell is shown. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols." @default.
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- W2894046652 date "2018-09-24" @default.
- W2894046652 modified "2023-09-26" @default.
- W2894046652 title "Chip-Based Heat Stimulation for Modulating Signal Propagation in HL-1 Cell Networks" @default.
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- W2894046652 doi "https://doi.org/10.1002/adbi.201800138" @default.
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