FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894048624> ?p ?o ?g. }

• W2894048624 abstract "Abstract Nematode chemosensory behaviors underlie fundamental processes and activities in development, reproduction, tropisms and taxes. For parasitic species, chemosensation is essential for host seeking and host and tissue invasion behaviors. Such fundamental biology presents an attractive target for developing behavior-blocking anthelminthic drugs, but the anatomy and functional relevance of parasitic nematode chemosensory machinery are poorly understood. The goals of this study were to better understand the chemosensory apparatus and behaviors of infectious stage Brugia malayi (Spirurida: Onchocercidae), a mosquito-borne nematode and etiological agent of Lymphatic Filariasis. Scanning electron microscopy revealed that amphids, the major chemosensory organs, are present on adult B. malayi and arranged in a conserved manner. Internal sensory neuroanatomy display structural differences between life stages, and a simpler chemosensory architecture as compared to free-living nematodes. Positive and negative chemotactic behaviors were identified for a repertoire of chemicals with known chemostimulatory activity for the mosquito host that may facilitate host-selectivity and invasion. This is the first description of chemosensory anatomy and chemotactic behaviors in B. malayi that reveal the involvement of chemosensation in parasite transmission and host invasion. Key findings • Amphidial arrangement in B. malayi is less complex than free-living nematodes. • Chemosensory neuroanatomy is stage-specific and simpler than free-living nematodes. • B. malayi responses to stimuli can be measured using a plate-based assay. • Chemostimulants associated with mosquito host-seeking induce negative and positive tropisms for L3 stage B. malayi ." @default.
• W2894048624 created "2018-10-05" @default.
• W2894048624 creator A5011820270 @default.
• W2894048624 creator A5012516644 @default.
• W2894048624 creator A5014847392 @default.
• W2894048624 creator A5061554624 @default.
• W2894048624 creator A5067946537 @default.
• W2894048624 creator A5068608615 @default.
• W2894048624 date "2018-09-26" @default.
• W2894048624 modified "2023-09-26" @default.
• W2894048624 title "Chemosensory structure and function in the filarial nematode, Brugia malayi" @default.
• W2894048624 cites W1590672771 @default.
• W2894048624 cites W1674860593 @default.
• W2894048624 cites W1965404074 @default.
• W2894048624 cites W1966124289 @default.
• W2894048624 cites W1968870896 @default.
• W2894048624 cites W1969633439 @default.
• W2894048624 cites W1977469171 @default.
• W2894048624 cites W1979321978 @default.
• W2894048624 cites W1982485110 @default.
• W2894048624 cites W1982617522 @default.
• W2894048624 cites W1990195067 @default.
• W2894048624 cites W1991615797 @default.
• W2894048624 cites W1993588490 @default.
• W2894048624 cites W1998491115 @default.
• W2894048624 cites W2003563200 @default.
• W2894048624 cites W2004738638 @default.
• W2894048624 cites W2005349613 @default.
• W2894048624 cites W2006130293 @default.
• W2894048624 cites W2013362889 @default.
• W2894048624 cites W2019033421 @default.
• W2894048624 cites W2020325973 @default.
• W2894048624 cites W2020790954 @default.
• W2894048624 cites W2022221238 @default.
• W2894048624 cites W2024406912 @default.
• W2894048624 cites W2034685592 @default.
• W2894048624 cites W2050815579 @default.
• W2894048624 cites W2057104531 @default.
• W2894048624 cites W2059627249 @default.
• W2894048624 cites W2059672533 @default.
• W2894048624 cites W2065877884 @default.
• W2894048624 cites W2078499757 @default.
• W2894048624 cites W2080729223 @default.
• W2894048624 cites W2081737180 @default.
• W2894048624 cites W2089851227 @default.
• W2894048624 cites W2093560688 @default.
• W2894048624 cites W2093561921 @default.
• W2894048624 cites W2094327183 @default.
• W2894048624 cites W2099763381 @default.
• W2894048624 cites W2113585283 @default.
• W2894048624 cites W2118895364 @default.
• W2894048624 cites W2121730382 @default.
• W2894048624 cites W2129349065 @default.
• W2894048624 cites W2132813211 @default.
• W2894048624 cites W2134533693 @default.
• W2894048624 cites W2138977648 @default.
• W2894048624 cites W2149210551 @default.
• W2894048624 cites W2153746682 @default.
• W2894048624 cites W2154326606 @default.
• W2894048624 cites W2156955261 @default.
• W2894048624 cites W2162684274 @default.
• W2894048624 cites W2163811687 @default.
• W2894048624 cites W2274464819 @default.
• W2894048624 cites W2316254458 @default.
• W2894048624 cites W2460413827 @default.
• W2894048624 cites W2578032984 @default.
• W2894048624 cites W2612453616 @default.
• W2894048624 cites W4211192430 @default.
• W2894048624 cites W4242895330 @default.
• W2894048624 doi "https://doi.org/10.1101/427229" @default.
• W2894048624 hasPublicationYear "2018" @default.
• W2894048624 type Work @default.
• W2894048624 sameAs 2894048624 @default.
• W2894048624 citedByCount "2" @default.
• W2894048624 countsByYear W28940486242019 @default.
• W2894048624 countsByYear W28940486242023 @default.
• W2894048624 crossrefType "posted-content" @default.
• W2894048624 hasAuthorship W2894048624A5011820270 @default.
• W2894048624 hasAuthorship W2894048624A5012516644 @default.
• W2894048624 hasAuthorship W2894048624A5014847392 @default.
• W2894048624 hasAuthorship W2894048624A5061554624 @default.
• W2894048624 hasAuthorship W2894048624A5067946537 @default.
• W2894048624 hasAuthorship W2894048624A5068608615 @default.
• W2894048624 hasBestOaLocation W28940486241 @default.
• W2894048624 hasConcept C103378370 @default.
• W2894048624 hasConcept C126831891 @default.
• W2894048624 hasConcept C165901193 @default.
• W2894048624 hasConcept C169760540 @default.
• W2894048624 hasConcept C18903297 @default.
• W2894048624 hasConcept C203014093 @default.
• W2894048624 hasConcept C2775848585 @default.
• W2894048624 hasConcept C2777629521 @default.
• W2894048624 hasConcept C2778830712 @default.
• W2894048624 hasConcept C86803240 @default.
• W2894048624 hasConcept C95444343 @default.
• W2894048624 hasConceptScore W2894048624C103378370 @default.
• W2894048624 hasConceptScore W2894048624C126831891 @default.
• W2894048624 hasConceptScore W2894048624C165901193 @default.
• W2894048624 hasConceptScore W2894048624C169760540 @default.
• W2894048624 hasConceptScore W2894048624C18903297 @default.

• next