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- W2894052415 abstract "Significance Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer and patients exhibit high rates of recurrence and mortality in part due to lack of treatment options beyond standard-of-care chemotherapy regimens. In the subset of TNBCs that express estrogen receptor beta (ERβ), ligand-mediated activation of ERβ elicits potent anticancer effects. We report here the elucidation of the ERβ cistrome and transcriptome in TNBC and identify a mechanism whereby ERβ induces cystatin gene expression resulting in inhibition of canonical TGFβ signaling and a blockade of metastatic phenotypes. These findings suggest that ERβ-targeted therapies represent a treatment option for the subset of women with ERβ-expressing TNBC." @default.
- W2894052415 created "2018-10-05" @default.
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- W2894052415 date "2018-09-26" @default.
- W2894052415 modified "2023-10-14" @default.
- W2894052415 title "ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis" @default.
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- W2894052415 doi "https://doi.org/10.1073/pnas.1807751115" @default.
- W2894052415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187171" @default.
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- W2894052415 hasPublicationYear "2018" @default.
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