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- W2894065078 abstract "Lack of auto osteogenesis and clinical complexities of repairing of bone after severe injuries, urge to develop a significant approach to promote regeneration of bone. The present work represents ornamentation of 2D rod-like nanohydroxyapatite (nHA) on ultra-low concentration graphene oxide (GO) sheet. The nanohybrids (GO-nHA) were incorporated into the spermine based high strength thermoplastic polyurethane-urea (PUU) matrices by in situ technique and the porous scaffolds were fabricated. 1 wt% GO-nHA filled scaffold displayed dramatically improved physico-mechanical properties. Cytotoxicity study using osteoblast cell like MG-63 cell line revealed positive cell viability (above 95%) and increased proliferation over a period of 14 days of culture. Semi-quantitative Real Time polymerase Chain Reaction (qRT-PCR) showed positive expression of collagen type I and osteocalcin indicating excellent maturation and biomineralization of osteoblasts. To avoid burden of carbonaceous particulate in body, very low percentage of GO (0.15%) was incorporated into the scaffold to improve mechanical properties, surface wettability, cell viability and cell proliferation drastically. Furthermore, in vivo study confirmed the promoted osteogenesis of PUU/GO-nHA scaffold in vivo without any cytotoxicity. Based on mechanical, in vitro and in vivo study the high strength nanohybrid scaffold exhibited tremendous potential for orthopedic applications." @default.
- W2894065078 created "2018-10-05" @default.
- W2894065078 creator A5055574140 @default.
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- W2894065078 date "2019-01-01" @default.
- W2894065078 modified "2023-10-18" @default.
- W2894065078 title "Coining attributes of ultra-low concentration graphene oxide and spermine: An approach for high strength, anti-microbial and osteoconductive nanohybrid scaffold for bone tissue regeneration" @default.
- W2894065078 cites W1473330989 @default.
- W2894065078 cites W1536195622 @default.
- W2894065078 cites W1536558090 @default.
- W2894065078 cites W1572706276 @default.
- W2894065078 cites W1595087412 @default.
- W2894065078 cites W1969280807 @default.
- W2894065078 cites W1971877746 @default.
- W2894065078 cites W1973994679 @default.
- W2894065078 cites W1988544802 @default.
- W2894065078 cites W1991152476 @default.
- W2894065078 cites W1992131471 @default.
- W2894065078 cites W1994250684 @default.
- W2894065078 cites W2002109048 @default.
- W2894065078 cites W2006264085 @default.
- W2894065078 cites W2010035324 @default.
- W2894065078 cites W2017581710 @default.
- W2894065078 cites W2024088694 @default.
- W2894065078 cites W2024902620 @default.
- W2894065078 cites W2025977396 @default.
- W2894065078 cites W2029069725 @default.
- W2894065078 cites W2030405603 @default.
- W2894065078 cites W2030970688 @default.
- W2894065078 cites W2039107753 @default.
- W2894065078 cites W2042371379 @default.
- W2894065078 cites W2042454875 @default.
- W2894065078 cites W2053555106 @default.
- W2894065078 cites W2055018199 @default.
- W2894065078 cites W2055930484 @default.
- W2894065078 cites W2056492898 @default.
- W2894065078 cites W2058633963 @default.
- W2894065078 cites W2061421331 @default.
- W2894065078 cites W2065825044 @default.
- W2894065078 cites W2067308798 @default.
- W2894065078 cites W2071183706 @default.
- W2894065078 cites W2073487879 @default.
- W2894065078 cites W2078933633 @default.
- W2894065078 cites W2079327424 @default.
- W2894065078 cites W2082451698 @default.
- W2894065078 cites W2083669880 @default.
- W2894065078 cites W2086846608 @default.
- W2894065078 cites W2090378839 @default.
- W2894065078 cites W2094592374 @default.
- W2894065078 cites W2095407037 @default.
- W2894065078 cites W2108499301 @default.
- W2894065078 cites W2109966590 @default.
- W2894065078 cites W2115473959 @default.
- W2894065078 cites W2119855827 @default.
- W2894065078 cites W2123739169 @default.
- W2894065078 cites W2132580436 @default.
- W2894065078 cites W2133511701 @default.
- W2894065078 cites W2137961190 @default.
- W2894065078 cites W2153588940 @default.
- W2894065078 cites W2162118093 @default.
- W2894065078 cites W2163121454 @default.
- W2894065078 cites W2170394629 @default.
- W2894065078 cites W2210806082 @default.
- W2894065078 cites W2234231219 @default.
- W2894065078 cites W2281027401 @default.
- W2894065078 cites W2293777747 @default.
- W2894065078 cites W2305924439 @default.
- W2894065078 cites W2322845683 @default.
- W2894065078 cites W2324455014 @default.
- W2894065078 cites W2328137824 @default.
- W2894065078 cites W2332322704 @default.
- W2894065078 cites W2430652796 @default.
- W2894065078 cites W2464434438 @default.
- W2894065078 cites W2466698266 @default.
- W2894065078 cites W2472608029 @default.
- W2894065078 cites W2604800494 @default.
- W2894065078 cites W2606445199 @default.
- W2894065078 cites W2615488293 @default.
- W2894065078 cites W2618650678 @default.
- W2894065078 cites W2626111189 @default.
- W2894065078 cites W2743226919 @default.
- W2894065078 cites W2790616655 @default.
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- W2894065078 doi "https://doi.org/10.1016/j.carbon.2018.09.062" @default.
- W2894065078 hasPublicationYear "2019" @default.
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