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• W2894066650 abstract "Previous structural studies of osteoprotegerin (OPG), a crucial negative regulator of bone remodeling and osteoclastogenesis, were mostly limited to the N-terminal ligand-binding domains. It is now known that the three C-terminal domains of OPG also play essential roles in its function by mediating OPG dimerization, OPG-heparan sulfate (HS) interactions, and formation of the OPG-HS-receptor activator of nuclear factor κB ligand (RANKL) ternary complex. Employing hydrogen-deuterium exchange MS methods, here we investigated the structure of full-length OPG in complex with HS or RANKL in solution. Our data revealed two noteworthy aspects of the OPG structure. First, we found that the interconnection between the N- and C-terminal domains is much more rigid than previously thought, possibly because of hydrophobic interactions between the fourth cysteine-rich domain and the first death domain. Second, we observed that two hydrophobic clusters located in two separate C-terminal domains directly contribute to OPG dimerization, likely by forming a hydrophobic dimerization interface. Aided by site-directed mutagenesis, we further demonstrated that an intact dimerization interface is essential for the biological activity of OPG. Our study represents an important step toward deciphering the structure-function relationship of the full-length OPG protein." @default.
• W2894066650 created "2018-10-05" @default.
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• W2894066650 date "2018-11-01" @default.
• W2894066650 modified "2023-10-18" @default.
• W2894066650 title "Dimerization interface of osteoprotegerin revealed by hydrogen–deuterium exchange mass spectrometry" @default.
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• W2894066650 doi "https://doi.org/10.1074/jbc.ra118.004489" @default.
• W2894066650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231129" @default.
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