Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894068810> ?p ?o ?g. }
- W2894068810 endingPage "175" @default.
- W2894068810 startingPage "165" @default.
- W2894068810 abstract "This study was conducted to investigate the ameliorative effect of selenium on microcystin-LR induced toxicity in bovine Sertoli cells. Bovine Sertoli cells were pretreated with selenium (Na2SeO3) for 24 h after which selenium pretreated and non-pretreated Sertoli cells were cultured in medium containing 10% heat activated fetal bovine serum FBS+ 80 µg/L MC-LR to assess its ameliorative effect on MC-LR toxicity. The results show that selenium pretreatment inhibited the MC-LR induced mitophagy, downregulation and mislocalization of blood-testis barrier constituent proteins in bovine Sertoli cells via NF-kB and cytochrome c release blockage. The observed downregulation of electron transport chain (ETC) related genes (mt-ND2, COX-1, COX-2) and upregulation of inflammatory cytokines (IL-6, TNF-α, IL-1β, IFN-γ, IL-4, IL-10, 1 L-13, TGFβ1) in non-pretreated cells exposed to MC-LR were ameliorated in selenium pretreated cells. There was no significant difference (P > 0.05) in the protein levels of blood-testis barrier constituent proteins (ZO-1, occludin, connexin-43, CTNNB1, N-cadherin) and mitochondria related genes (mt-ND2, COX-1, COX-2, ACAT1, mtTFA) of selenium pretreated Sertoli cell compared to the control. Taken together, we conclude that selenium inhibits MC-LR caused Mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell via mitochondrial and TLR4/NF-kB signaling pathways blockage." @default.
- W2894068810 created "2018-10-05" @default.
- W2894068810 creator A5002069535 @default.
- W2894068810 creator A5014964945 @default.
- W2894068810 creator A5041100767 @default.
- W2894068810 creator A5043126622 @default.
- W2894068810 creator A5053658255 @default.
- W2894068810 creator A5054441443 @default.
- W2894068810 creator A5056332977 @default.
- W2894068810 creator A5075828102 @default.
- W2894068810 creator A5090898144 @default.
- W2894068810 date "2018-12-01" @default.
- W2894068810 modified "2023-10-16" @default.
- W2894068810 title "Sodium Selenite inhibits mitophagy, downregulation and mislocalization of blood-testis barrier proteins of bovine Sertoli cell exposed to microcystin-leucine arginine (MC-LR) via TLR4/NF-kB and mitochondrial signaling pathways blockage" @default.
- W2894068810 cites W1489771292 @default.
- W2894068810 cites W1491181689 @default.
- W2894068810 cites W1523768703 @default.
- W2894068810 cites W1551392207 @default.
- W2894068810 cites W1564793130 @default.
- W2894068810 cites W1909163727 @default.
- W2894068810 cites W1968714545 @default.
- W2894068810 cites W1973122402 @default.
- W2894068810 cites W1973210866 @default.
- W2894068810 cites W1974890191 @default.
- W2894068810 cites W1976323290 @default.
- W2894068810 cites W1976417809 @default.
- W2894068810 cites W1977216200 @default.
- W2894068810 cites W1981522941 @default.
- W2894068810 cites W1986370482 @default.
- W2894068810 cites W1986618045 @default.
- W2894068810 cites W1986621238 @default.
- W2894068810 cites W1988564839 @default.
- W2894068810 cites W1996122553 @default.
- W2894068810 cites W2000376380 @default.
- W2894068810 cites W2003912126 @default.
- W2894068810 cites W2007460428 @default.
- W2894068810 cites W2011405926 @default.
- W2894068810 cites W2011560862 @default.
- W2894068810 cites W2011563399 @default.
- W2894068810 cites W2012443958 @default.
- W2894068810 cites W2012859890 @default.
- W2894068810 cites W2018866981 @default.
- W2894068810 cites W2024979614 @default.
- W2894068810 cites W2026492207 @default.
- W2894068810 cites W2026787463 @default.
- W2894068810 cites W2027382657 @default.
- W2894068810 cites W2030432802 @default.
- W2894068810 cites W2032077087 @default.
- W2894068810 cites W2038372048 @default.
- W2894068810 cites W2042355470 @default.
- W2894068810 cites W2042603980 @default.
- W2894068810 cites W2044003580 @default.
- W2894068810 cites W2044496334 @default.
- W2894068810 cites W2045509536 @default.
- W2894068810 cites W2046011724 @default.
- W2894068810 cites W2046200462 @default.
- W2894068810 cites W2050054653 @default.
- W2894068810 cites W2062033471 @default.
- W2894068810 cites W2062461025 @default.
- W2894068810 cites W2066306511 @default.
- W2894068810 cites W2066410018 @default.
- W2894068810 cites W2072898133 @default.
- W2894068810 cites W2072930156 @default.
- W2894068810 cites W2077012992 @default.
- W2894068810 cites W2077252950 @default.
- W2894068810 cites W2078712181 @default.
- W2894068810 cites W2085768512 @default.
- W2894068810 cites W2089606595 @default.
- W2894068810 cites W2112683748 @default.
- W2894068810 cites W2122039020 @default.
- W2894068810 cites W2131415852 @default.
- W2894068810 cites W2136308062 @default.
- W2894068810 cites W2139248293 @default.
- W2894068810 cites W2154262496 @default.
- W2894068810 cites W2159995728 @default.
- W2894068810 cites W2161789287 @default.
- W2894068810 cites W2168894423 @default.
- W2894068810 cites W2280955573 @default.
- W2894068810 cites W2293782839 @default.
- W2894068810 cites W2515470583 @default.
- W2894068810 cites W2562474273 @default.
- W2894068810 cites W2741446350 @default.
- W2894068810 cites W2769592452 @default.
- W2894068810 cites W2788422364 @default.
- W2894068810 cites W2890127217 @default.
- W2894068810 cites W315927324 @default.
- W2894068810 doi "https://doi.org/10.1016/j.ecoenv.2018.09.073" @default.
- W2894068810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267989" @default.
- W2894068810 hasPublicationYear "2018" @default.
- W2894068810 type Work @default.
- W2894068810 sameAs 2894068810 @default.
- W2894068810 citedByCount "22" @default.
- W2894068810 countsByYear W28940688102019 @default.
- W2894068810 countsByYear W28940688102021 @default.
- W2894068810 countsByYear W28940688102022 @default.
- W2894068810 countsByYear W28940688102023 @default.
- W2894068810 crossrefType "journal-article" @default.
- W2894068810 hasAuthorship W2894068810A5002069535 @default.