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• W2894069312 abstract "Silver nanoparticle (AgNP)-loaded polymeric constructs are widely investigated for potential applications as drug delivery systems, wound dressings, and antibiofouling biomaterials. Herein, the authors present several methods for fabricating such materials and evaluate their efficacy against Escherichia coli. H2O(v) plasma surface modification is employed to enhance material surface wettability (explored by water contact angle goniometry) and nanoparticle incorporation. Compositional analyses reveal that incorporation of AgNPs on the surface and bulk of the materials strongly depends on the fabrication methodology. More importantly, the nature of AgNP incorporation into the polymer has direct implications on the biocidal performance resulting from the release of Ag+. The materials fabricated herein fell significantly short of healthcare standards with respect to antimicrobial behavior, and, in comparing their results to numerous literature studies, the authors identified a glaring disparity in the way such results are often described. Thus, this work also contains a critical evaluation of the literature, highlighting select poor-performing materials to demonstrate several shortcomings in the quantitative analysis and reporting of the antibacterial efficacy of AgNP-loaded materials. Ultimately, recommendations for best practices for better evaluation of these constructs toward improved antibacterial efficacy in medical settings are provided." @default.
• W2894069312 created "2018-10-05" @default.
• W2894069312 creator A5007226997 @default.
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• W2894069312 date "2018-09-27" @default.
• W2894069312 modified "2023-09-26" @default.
• W2894069312 title "Perspectives on antibacterial performance of silver nanoparticle-loaded three-dimensional polymeric constructs" @default.
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• W2894069312 doi "https://doi.org/10.1116/1.5042426" @default.
• W2894069312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261733" @default.
• W2894069312 hasPublicationYear "2018" @default.
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