Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894071621> ?p ?o ?g. }
- W2894071621 endingPage "1504" @default.
- W2894071621 startingPage "1501" @default.
- W2894071621 abstract "Some of the most unique and compelling survival strategies in the natural world are fixed in isolated species1. To date, molecular insight into these ancient adaptations has been limited, as classic experimental genetics has focused on interfertile individuals in populations2. Here we use a new mapping approach, which screens mutants in a sterile interspecific hybrid, to identify eight housekeeping genes that underlie the growth advantage of Saccharomyces cerevisiae over its distant relative Saccharomyces paradoxus at high temperature. Pro-thermotolerance alleles at these mapped loci were required for the adaptive trait in S. cerevisiae and sufficient for its partial reconstruction in S. paradoxus. The emerging picture is one in which S. cerevisiae improved the heat resistance of multiple components of the fundamental growth machinery in response to selective pressure. Our study lays the groundwork for the mapping of genotype to phenotype in clades of sister species across Eukarya. A mapping approach that screens mutants in a sterile interspecific hybrid identifies the genetic determinants of differences in high-temperature growth between divergent Saccharomyces cerevisiae and Saccharomyces paradoxus yeast species." @default.
- W2894071621 created "2018-10-05" @default.
- W2894071621 creator A5007647654 @default.
- W2894071621 creator A5012271946 @default.
- W2894071621 creator A5026237495 @default.
- W2894071621 creator A5037421535 @default.
- W2894071621 creator A5053314432 @default.
- W2894071621 creator A5055779391 @default.
- W2894071621 creator A5065477827 @default.
- W2894071621 creator A5066623854 @default.
- W2894071621 date "2018-10-08" @default.
- W2894071621 modified "2023-10-02" @default.
- W2894071621 title "Genetic dissection of interspecific differences in yeast thermotolerance" @default.
- W2894071621 cites W1584117454 @default.
- W2894071621 cites W1850569493 @default.
- W2894071621 cites W1898780412 @default.
- W2894071621 cites W1953530917 @default.
- W2894071621 cites W1975604268 @default.
- W2894071621 cites W1984814148 @default.
- W2894071621 cites W1985651950 @default.
- W2894071621 cites W1988644644 @default.
- W2894071621 cites W1993289212 @default.
- W2894071621 cites W1998306498 @default.
- W2894071621 cites W2018085822 @default.
- W2894071621 cites W2034869568 @default.
- W2894071621 cites W2044348714 @default.
- W2894071621 cites W2074870686 @default.
- W2894071621 cites W2100062780 @default.
- W2894071621 cites W2108234281 @default.
- W2894071621 cites W2110335151 @default.
- W2894071621 cites W2113030587 @default.
- W2894071621 cites W2123566082 @default.
- W2894071621 cites W2132579058 @default.
- W2894071621 cites W2140948740 @default.
- W2894071621 cites W2147225992 @default.
- W2894071621 cites W2155507858 @default.
- W2894071621 cites W2160378127 @default.
- W2894071621 cites W2160588775 @default.
- W2894071621 cites W2160824531 @default.
- W2894071621 cites W2166699835 @default.
- W2894071621 cites W2170392103 @default.
- W2894071621 cites W2170551349 @default.
- W2894071621 cites W2171679524 @default.
- W2894071621 cites W2270687628 @default.
- W2894071621 cites W2535283300 @default.
- W2894071621 cites W2590059905 @default.
- W2894071621 cites W2622859909 @default.
- W2894071621 cites W2765922336 @default.
- W2894071621 cites W4253276208 @default.
- W2894071621 cites W93588716 @default.
- W2894071621 doi "https://doi.org/10.1038/s41588-018-0243-4" @default.
- W2894071621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6430122" @default.
- W2894071621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30297967" @default.
- W2894071621 hasPublicationYear "2018" @default.
- W2894071621 type Work @default.
- W2894071621 sameAs 2894071621 @default.
- W2894071621 citedByCount "39" @default.
- W2894071621 countsByYear W28940716212018 @default.
- W2894071621 countsByYear W28940716212019 @default.
- W2894071621 countsByYear W28940716212020 @default.
- W2894071621 countsByYear W28940716212021 @default.
- W2894071621 countsByYear W28940716212022 @default.
- W2894071621 countsByYear W28940716212023 @default.
- W2894071621 crossrefType "journal-article" @default.
- W2894071621 hasAuthorship W2894071621A5007647654 @default.
- W2894071621 hasAuthorship W2894071621A5012271946 @default.
- W2894071621 hasAuthorship W2894071621A5026237495 @default.
- W2894071621 hasAuthorship W2894071621A5037421535 @default.
- W2894071621 hasAuthorship W2894071621A5053314432 @default.
- W2894071621 hasAuthorship W2894071621A5055779391 @default.
- W2894071621 hasAuthorship W2894071621A5065477827 @default.
- W2894071621 hasAuthorship W2894071621A5066623854 @default.
- W2894071621 hasBestOaLocation W28940716213 @default.
- W2894071621 hasConcept C104317684 @default.
- W2894071621 hasConcept C150194340 @default.
- W2894071621 hasConcept C180754005 @default.
- W2894071621 hasConcept C18903297 @default.
- W2894071621 hasConcept C2777576037 @default.
- W2894071621 hasConcept C2778447961 @default.
- W2894071621 hasConcept C2779222958 @default.
- W2894071621 hasConcept C33922130 @default.
- W2894071621 hasConcept C54355233 @default.
- W2894071621 hasConcept C63644423 @default.
- W2894071621 hasConcept C78458016 @default.
- W2894071621 hasConcept C86803240 @default.
- W2894071621 hasConceptScore W2894071621C104317684 @default.
- W2894071621 hasConceptScore W2894071621C150194340 @default.
- W2894071621 hasConceptScore W2894071621C180754005 @default.
- W2894071621 hasConceptScore W2894071621C18903297 @default.
- W2894071621 hasConceptScore W2894071621C2777576037 @default.
- W2894071621 hasConceptScore W2894071621C2778447961 @default.
- W2894071621 hasConceptScore W2894071621C2779222958 @default.
- W2894071621 hasConceptScore W2894071621C33922130 @default.
- W2894071621 hasConceptScore W2894071621C54355233 @default.
- W2894071621 hasConceptScore W2894071621C63644423 @default.
- W2894071621 hasConceptScore W2894071621C78458016 @default.
- W2894071621 hasConceptScore W2894071621C86803240 @default.
- W2894071621 hasIssue "11" @default.