FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894080340> ?p ?o ?g. }

• W2894080340 endingPage "209" @default.
• W2894080340 startingPage "209" @default.
• W2894080340 abstract "BACKGROUND/PURPOSE: 3D-printed bioactive ceramic (3DPBC) scaffolds composed of beta-tricalcium phosphate (β-TCP) and coated in the osteogenic agent dipyridamole (DIPY) have been previously shown to heal critically sized calvarial defects in several adult animal models.1–3 This bone tissue engineering construct has yet to be applied in a pediatric craniofacial model where the pathologic effects of osteogenic agents on the growing sutures may be of concern. The purpose of this study is to apply the described bone tissue engineering construct in a pediatric growing animal model and 1) quantify osteogenic potential in a growing calvarium; 2) maximize the scaffold design and dipyridamole concentration for the growing calvarium; and 3) characterize the effects of this bone tissue engineering construct on the growing suture. METHODS/DESCRIPTION: Bilateral calvarial defects (10 mm) were created in 5-week-old New Zealand White rabbits (n = 14) 2mm posterior and lateral to the coronal suture and sagittal sutures, respectively. 3DPBC scaffolds were constructed in quadrant form composed varying pore dimensions (220μm, 330μm, 500μm). Each scaffold was collagen coated and soaked in varying concentrations of DIPY (100μM, 1000μM, 10,000μM). Controls comprised empty defects and collagen coated scaffolds. Scaffolds were then placed into the calvarial defects to fill the bone space. Animals were euthanized 8-weeks post-operatively. Calvaria were analyzed using micro-computed tomography and 3D reconstruction. Mixed model analyses were conducted considering pore size and dosage effects on bone growth (a=0.05). RESULTS: 3DPBC scaffolds generated bone throughout the construct (defect marginal and central regions) while bone healing in empty sites was restricted to the defect margins confirming its critical size dimension at 8 weeks in vivo. When evaluating volume occupied by bone solely as factor of pore size (small, medium, and large), the small pores yielded the highest mean value (26.8% ± 3.4) when compared to medium and large. However, analysis indicted no statistical differences between the sizes (p>0.10). In assessing the effectiveness of coating the scaffold in either collagen or dipyridamole (DIPY), higher mean bone occupancy values were observed in the scaffolds coated in 1,000μM DIPY (27.9% ± 4.05), which was significantly greater in comparison to the collagen-coated scaffolds (20.9% ± 4.43, p=0.021). Growing cranial sutures remained patent across all concentrations of DIPY, including 10,000μM. CONCLUSION: 3DPBC scaffolds effectively generates bone in a growing calvarial animal model. Pore size and dipyridamole dose has been optimized for the growing cranium. Cranial suture patency is preserved even at a 2 log increase over the effective ostetogenic dose. References: 1. Ishack S, Mediero A, Wilder T, Ricci JL, Cronstein BN. Bone regeneration in critical bone defects using three-dimensionally printed beta-tricalcium phosphate/hydroxyapatite scaffolds is enhanced by coating scaffolds with either dipyridamole or BMP-2. J Biomed Mater Res B Appl Biomater 2017;105:366–75. 2. Simon JL, Michna S, Lewis JA, et al. In vivo bone response to 3D periodic hydroxyapatite scaffolds assembled by direct ink writing. J Biomed Mater Res A 2007;83:747–58. 3. Bekisz JM, Flores RL, Witek L, et al. Dipyridamole enhances osteogenesis of three-dimensionally printed bioactive ceramic scaffolds in calvarial defects. J Craniomaxillofac Surg 2017." @default.
• W2894080340 created "2018-10-05" @default.
• W2894080340 creator A5001627010 @default.
• W2894080340 creator A5005978785 @default.
• W2894080340 creator A5009659646 @default.
• W2894080340 creator A5021769570 @default.
• W2894080340 creator A5028924934 @default.
• W2894080340 creator A5044753138 @default.
• W2894080340 creator A5047291265 @default.
• W2894080340 creator A5074159148 @default.
• W2894080340 creator A5083811481 @default.
• W2894080340 creator A5087009310 @default.
• W2894080340 date "2018-09-01" @default.
• W2894080340 modified "2023-09-30" @default.
• W2894080340 title "Abstract: 3D-Printed Bioactive Ceramic Scaffolds for Induction of Osteogenesis in the Immature Skeleton" @default.
• W2894080340 doi "https://doi.org/10.1097/01.gox.0000547106.01253.f7" @default.
• W2894080340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6212247" @default.
• W2894080340 hasPublicationYear "2018" @default.
• W2894080340 type Work @default.
• W2894080340 sameAs 2894080340 @default.
• W2894080340 citedByCount "0" @default.
• W2894080340 crossrefType "journal-article" @default.
• W2894080340 hasAuthorship W2894080340A5001627010 @default.
• W2894080340 hasAuthorship W2894080340A5005978785 @default.
• W2894080340 hasAuthorship W2894080340A5009659646 @default.
• W2894080340 hasAuthorship W2894080340A5021769570 @default.
• W2894080340 hasAuthorship W2894080340A5028924934 @default.
• W2894080340 hasAuthorship W2894080340A5044753138 @default.
• W2894080340 hasAuthorship W2894080340A5047291265 @default.
• W2894080340 hasAuthorship W2894080340A5074159148 @default.
• W2894080340 hasAuthorship W2894080340A5083811481 @default.
• W2894080340 hasAuthorship W2894080340A5087009310 @default.
• W2894080340 hasBestOaLocation W28940803401 @default.
• W2894080340 hasConcept C105702510 @default.
• W2894080340 hasConcept C126322002 @default.
• W2894080340 hasConcept C13483470 @default.
• W2894080340 hasConcept C136229726 @default.
• W2894080340 hasConcept C185592680 @default.
• W2894080340 hasConcept C192562407 @default.
• W2894080340 hasConcept C199343813 @default.
• W2894080340 hasConcept C202751555 @default.
• W2894080340 hasConcept C2777327002 @default.
• W2894080340 hasConcept C2779300802 @default.
• W2894080340 hasConcept C2779918246 @default.
• W2894080340 hasConcept C2991750140 @default.
• W2894080340 hasConcept C49892992 @default.
• W2894080340 hasConcept C55493867 @default.
• W2894080340 hasConcept C71924100 @default.
• W2894080340 hasConcept C89429830 @default.
• W2894080340 hasConceptScore W2894080340C105702510 @default.
• W2894080340 hasConceptScore W2894080340C126322002 @default.
• W2894080340 hasConceptScore W2894080340C13483470 @default.
• W2894080340 hasConceptScore W2894080340C136229726 @default.
• W2894080340 hasConceptScore W2894080340C185592680 @default.
• W2894080340 hasConceptScore W2894080340C192562407 @default.
• W2894080340 hasConceptScore W2894080340C199343813 @default.
• W2894080340 hasConceptScore W2894080340C202751555 @default.
• W2894080340 hasConceptScore W2894080340C2777327002 @default.
• W2894080340 hasConceptScore W2894080340C2779300802 @default.
• W2894080340 hasConceptScore W2894080340C2779918246 @default.
• W2894080340 hasConceptScore W2894080340C2991750140 @default.
• W2894080340 hasConceptScore W2894080340C49892992 @default.
• W2894080340 hasConceptScore W2894080340C55493867 @default.
• W2894080340 hasConceptScore W2894080340C71924100 @default.
• W2894080340 hasConceptScore W2894080340C89429830 @default.
• W2894080340 hasIssue "9S" @default.
• W2894080340 hasLocation W28940803401 @default.
• W2894080340 hasLocation W28940803402 @default.
• W2894080340 hasLocation W28940803403 @default.
• W2894080340 hasLocation W28940803404 @default.
• W2894080340 hasOpenAccess W2894080340 @default.
• W2894080340 hasPrimaryLocation W28940803401 @default.
• W2894080340 hasRelatedWork W1984871082 @default.
• W2894080340 hasRelatedWork W1991592917 @default.
• W2894080340 hasRelatedWork W2014092735 @default.
• W2894080340 hasRelatedWork W2028744988 @default.
• W2894080340 hasRelatedWork W2034914903 @default.
• W2894080340 hasRelatedWork W2056705001 @default.
• W2894080340 hasRelatedWork W2096303359 @default.
• W2894080340 hasRelatedWork W2117530083 @default.
• W2894080340 hasRelatedWork W3096083099 @default.
• W2894080340 hasRelatedWork W3141771089 @default.
• W2894080340 hasVolume "6" @default.
• W2894080340 isParatext "false" @default.
• W2894080340 isRetracted "false" @default.
• W2894080340 magId "2894080340" @default.
• W2894080340 workType "article" @default.