Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894085647> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2894085647 abstract "Introduction Systemic Lupus Erythematosus (SLE) increases the risk of unfavorable pregnancy outcomes including preterm birth and preeclampsia (PE). Flare-up of SLE during pregnancy or after birth is also problematic. TLR4 signaling is known to exacerbate both SLE and pregnancy. We have shown that nicotinamide (NAM), a non-teratogenic amide of vitamin B3, reduces inflammation and oxidative stress, and improves PE-like phenotype in mouse models of PE (Takahashi et al. PNAS 2016). Objective The aim of the present study is to establish a mouse model to study pathogenesis and treatment of SLE patients suffering from PE, and to test whether nicotinamide (NAM) is beneficial to preeclamptic SLE mice. Methods and results We administered low dose LPS, a TLR4 ligand, to pregnant lupus-prone MRL/lpr mice, and analyzed maternal and fetal outcomes. LPS increased blood pressure, caused fetal growth restriction (FGR), and exacerbated glomerulonephritis in MRL/lpr-LPS mouse. We conclude that this is a suitable model to study pathogenesis of pregnancy in SLE. We next examined a therapeutic effect of NAM on the pregnancy outcome and lupus nephritis in pregnant MRL/lpr mice given LPS. NAM (500 mg/kg) was administered on 13.5–17.5 dpc, and data and samples were collected on 18.5 dpc. NAM decreased maternal blood pressure, prolonged pregnancy period, and corrected FGR. NAM significantly improved glomerular injury and inflammatory cell infiltration, which was accompanied by reduced expression of inflammatory cytokines in their kidneys. NAM also decreased the level of plasma anti-dsDNA antibody and lymphadenopathy. Discussion NAM alleviates PE-like features, FGR, and lupus activity in MRL/lpr-LPS model. NAM may be a novel therapeutic option to benefit pregnant SLE patients." @default.
- W2894085647 created "2018-10-05" @default.
- W2894085647 creator A5008427196 @default.
- W2894085647 creator A5010489513 @default.
- W2894085647 creator A5026509663 @default.
- W2894085647 creator A5043121221 @default.
- W2894085647 creator A5059310932 @default.
- W2894085647 creator A5059710641 @default.
- W2894085647 creator A5063684510 @default.
- W2894085647 creator A5065937535 @default.
- W2894085647 creator A5066495888 @default.
- W2894085647 date "2018-10-01" @default.
- W2894085647 modified "2023-10-17" @default.
- W2894085647 title "130. Nicotinamide alleviates preeclampsia-like features and lupus nephritis in pregnant MRL/lpr mice treated with LPS" @default.
- W2894085647 doi "https://doi.org/10.1016/j.preghy.2018.08.241" @default.
- W2894085647 hasPublicationYear "2018" @default.
- W2894085647 type Work @default.
- W2894085647 sameAs 2894085647 @default.
- W2894085647 citedByCount "0" @default.
- W2894085647 crossrefType "journal-article" @default.
- W2894085647 hasAuthorship W2894085647A5008427196 @default.
- W2894085647 hasAuthorship W2894085647A5010489513 @default.
- W2894085647 hasAuthorship W2894085647A5026509663 @default.
- W2894085647 hasAuthorship W2894085647A5043121221 @default.
- W2894085647 hasAuthorship W2894085647A5059310932 @default.
- W2894085647 hasAuthorship W2894085647A5059710641 @default.
- W2894085647 hasAuthorship W2894085647A5063684510 @default.
- W2894085647 hasAuthorship W2894085647A5065937535 @default.
- W2894085647 hasAuthorship W2894085647A5066495888 @default.
- W2894085647 hasConcept C126322002 @default.
- W2894085647 hasConcept C134018914 @default.
- W2894085647 hasConcept C181199279 @default.
- W2894085647 hasConcept C203014093 @default.
- W2894085647 hasConcept C2776912625 @default.
- W2894085647 hasConcept C2776914184 @default.
- W2894085647 hasConcept C2777218350 @default.
- W2894085647 hasConcept C2779134260 @default.
- W2894085647 hasConcept C2779234561 @default.
- W2894085647 hasConcept C2779728014 @default.
- W2894085647 hasConcept C2779912601 @default.
- W2894085647 hasConcept C2780942790 @default.
- W2894085647 hasConcept C54355233 @default.
- W2894085647 hasConcept C55493867 @default.
- W2894085647 hasConcept C71924100 @default.
- W2894085647 hasConcept C86803240 @default.
- W2894085647 hasConceptScore W2894085647C126322002 @default.
- W2894085647 hasConceptScore W2894085647C134018914 @default.
- W2894085647 hasConceptScore W2894085647C181199279 @default.
- W2894085647 hasConceptScore W2894085647C203014093 @default.
- W2894085647 hasConceptScore W2894085647C2776912625 @default.
- W2894085647 hasConceptScore W2894085647C2776914184 @default.
- W2894085647 hasConceptScore W2894085647C2777218350 @default.
- W2894085647 hasConceptScore W2894085647C2779134260 @default.
- W2894085647 hasConceptScore W2894085647C2779234561 @default.
- W2894085647 hasConceptScore W2894085647C2779728014 @default.
- W2894085647 hasConceptScore W2894085647C2779912601 @default.
- W2894085647 hasConceptScore W2894085647C2780942790 @default.
- W2894085647 hasConceptScore W2894085647C54355233 @default.
- W2894085647 hasConceptScore W2894085647C55493867 @default.
- W2894085647 hasConceptScore W2894085647C71924100 @default.
- W2894085647 hasConceptScore W2894085647C86803240 @default.
- W2894085647 hasLocation W28940856471 @default.
- W2894085647 hasOpenAccess W2894085647 @default.
- W2894085647 hasPrimaryLocation W28940856471 @default.
- W2894085647 hasRelatedWork W1590369543 @default.
- W2894085647 hasRelatedWork W1979969797 @default.
- W2894085647 hasRelatedWork W2012418058 @default.
- W2894085647 hasRelatedWork W2068477620 @default.
- W2894085647 hasRelatedWork W2097747813 @default.
- W2894085647 hasRelatedWork W2313065437 @default.
- W2894085647 hasRelatedWork W2367356340 @default.
- W2894085647 hasRelatedWork W2372507510 @default.
- W2894085647 hasRelatedWork W2460676119 @default.
- W2894085647 hasRelatedWork W2763137289 @default.
- W2894085647 isParatext "false" @default.
- W2894085647 isRetracted "false" @default.
- W2894085647 magId "2894085647" @default.
- W2894085647 workType "article" @default.