FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2894087757> ?p ?o ?g. }

• W2894087757 endingPage "2588" @default.
• W2894087757 startingPage "2575" @default.
• W2894087757 abstract "Multiple sclerosis (MS) and neuromyelitis optica (NMO) are inflammatory demyelinating disorders of the central nervous system with evidence of antibody-mediated pathology. Using ex vivo organotypic mouse cerebellar slice cultures, we have demonstrated that recombinant antibodies (rAbs) cloned from cerebrospinal fluid plasmablasts of MS and NMO patients target myelin- and astrocyte-specific antigens to induce disease-specific oligodendrocyte loss and myelin degradation. In this study, we examined glial cell responses and myelin integrity during recovery from disease-specific antibody-mediated injury. Following exposure to MS rAb and human complement (HC) in cerebellar explants, myelinating oligodendrocytes repopulated the demyelinated tissue and formed new myelin sheaths along axons. Remyelination was accompanied by pronounced microglial activation. In contrast, following treatment with NMO rAb and HC, there was rapid regeneration of astrocytes and pre-myelinating oligodendrocytes but little formation of myelin sheaths on preserved axons. Deficient remyelination was associated with progressive axonal loss and the return of microglia to a resting state. Our results indicate that antibody-mediated demyelination in MS and NMO show distinct capacities for recovery associated with differential injury to adjacent axons and variable activation of microglia. Remyelination was rapid in MS rAb plus HC-induced demyelination. By contrast, oligodendrocyte maturation and remyelination failed following NMO rAb-mediated injury despite the rapid restoration of astrocytes and preservation of axons in early lesions." @default.
• W2894087757 created "2018-10-05" @default.
• W2894087757 creator A5016397545 @default.
• W2894087757 creator A5032201780 @default.
• W2894087757 creator A5039030016 @default.
• W2894087757 creator A5062518246 @default.
• W2894087757 creator A5071825865 @default.
• W2894087757 date "2018-09-21" @default.
• W2894087757 modified "2023-10-17" @default.
• W2894087757 title "Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica" @default.
• W2894087757 cites W1563760251 @default.
• W2894087757 cites W1606708074 @default.
• W2894087757 cites W1860574066 @default.
• W2894087757 cites W1922994157 @default.
• W2894087757 cites W1934658365 @default.
• W2894087757 cites W1953446118 @default.
• W2894087757 cites W1975434091 @default.
• W2894087757 cites W1977213877 @default.
• W2894087757 cites W1979550850 @default.
• W2894087757 cites W1981657951 @default.
• W2894087757 cites W1985932810 @default.
• W2894087757 cites W1994966944 @default.
• W2894087757 cites W1996932689 @default.
• W2894087757 cites W2003209934 @default.
• W2894087757 cites W2018439132 @default.
• W2894087757 cites W2043009782 @default.
• W2894087757 cites W2052761964 @default.
• W2894087757 cites W2053542015 @default.
• W2894087757 cites W2053646585 @default.
• W2894087757 cites W2062403533 @default.
• W2894087757 cites W2063804453 @default.
• W2894087757 cites W2065700461 @default.
• W2894087757 cites W2073960456 @default.
• W2894087757 cites W2077427574 @default.
• W2894087757 cites W2082317598 @default.
• W2894087757 cites W2086080135 @default.
• W2894087757 cites W2096423240 @default.
• W2894087757 cites W2110633552 @default.
• W2894087757 cites W2112064552 @default.
• W2894087757 cites W2112285382 @default.
• W2894087757 cites W2117629989 @default.
• W2894087757 cites W2122587876 @default.
• W2894087757 cites W2123311421 @default.
• W2894087757 cites W2134885049 @default.
• W2894087757 cites W2142808413 @default.
• W2894087757 cites W2147062889 @default.
• W2894087757 cites W2149429081 @default.
• W2894087757 cites W2156918730 @default.
• W2894087757 cites W2157780675 @default.
• W2894087757 cites W2161480852 @default.
• W2894087757 cites W2162978315 @default.
• W2894087757 cites W2166005298 @default.
• W2894087757 cites W2171013521 @default.
• W2894087757 cites W2206286096 @default.
• W2894087757 cites W2206873254 @default.
• W2894087757 cites W2206947362 @default.
• W2894087757 cites W2281702574 @default.
• W2894087757 cites W2284732792 @default.
• W2894087757 cites W2295979384 @default.
• W2894087757 cites W2344109506 @default.
• W2894087757 cites W2345329114 @default.
• W2894087757 cites W2347029776 @default.
• W2894087757 cites W2407121184 @default.
• W2894087757 cites W2463465074 @default.
• W2894087757 cites W2518879373 @default.
• W2894087757 cites W2522122785 @default.
• W2894087757 cites W2527645962 @default.
• W2894087757 cites W2559337508 @default.
• W2894087757 cites W2594403755 @default.
• W2894087757 cites W2600133287 @default.
• W2894087757 cites W2606181937 @default.
• W2894087757 cites W2612531229 @default.
• W2894087757 cites W2742028728 @default.
• W2894087757 cites W2749489383 @default.
• W2894087757 cites W2753593979 @default.
• W2894087757 cites W2766753632 @default.
• W2894087757 cites W2795024322 @default.
• W2894087757 doi "https://doi.org/10.1002/glia.23512" @default.
• W2894087757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309481" @default.
• W2894087757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240044" @default.
• W2894087757 hasPublicationYear "2018" @default.
• W2894087757 type Work @default.
• W2894087757 sameAs 2894087757 @default.
• W2894087757 citedByCount "21" @default.
• W2894087757 countsByYear W28940877572019 @default.
• W2894087757 countsByYear W28940877572020 @default.
• W2894087757 countsByYear W28940877572021 @default.
• W2894087757 countsByYear W28940877572022 @default.
• W2894087757 countsByYear W28940877572023 @default.
• W2894087757 crossrefType "journal-article" @default.
• W2894087757 hasAuthorship W2894087757A5016397545 @default.
• W2894087757 hasAuthorship W2894087757A5032201780 @default.
• W2894087757 hasAuthorship W2894087757A5039030016 @default.
• W2894087757 hasAuthorship W2894087757A5062518246 @default.
• W2894087757 hasAuthorship W2894087757A5071825865 @default.
• W2894087757 hasBestOaLocation W28940877572 @default.
• W2894087757 hasConcept C142724271 @default.
• W2894087757 hasConcept C169760540 @default.

• next